2004 Fiscal Year Final Research Report Summary
Development and Application of Graphical Modeling techniques for Assesshrg the Joint Risks of Contaminants
| Project/Area Number |
15300093
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Statistical science
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| Research Institution | Kurume University (2004)
Kyushu University (2003) |
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Principal Investigator |
YANAGAWA Takashi Kurume University, Biostatistics Center, Professor, バイオ統計センター, 教授 (80029488)
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| Co-Investigator(Kenkyū-buntansha) |
KONISHI Sadanori Kyushu University, Faculty of Mathematics, Professor, 大学院・数理学研究院, 教授 (40090550)
HYAKUTAKE Hiroto Kyushu University, Faculty of Mathematics, Associate Professor, 大学院・数理学研究院, 助教授 (70181120)
UCHIDA Masayuki Kyushu University, Faculty of Mathematics, Associate Professor, 大学院・数理学研究院, 助教授 (70280526)
NINOMIYA Yoshiyuki Kyushu University, Faculty of Mathematics, Assistant Professor, 大学院・数理学研究院, 助手 (50343330)
KAWAGUCHI Atsudhi Kurume University, Biostatistics Center, Research fellow, バイオ統計センター, 研究員 (60389319)
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| Project Period (FY) |
2003 – 2004
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| Keywords | graphical modeling / causal relationship / nonlinear modeling / Bayes information criterion / asymptotic theory / rank correlation / negative binomial distribution / diffusion process |
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| Research Abstract |
The graphical modeling techniques which have been proposed for the analysis of complex causal relationship are developed under the assumption of multivariate normal distribution. Thus they are limited for modeling only linear cause-effect relationships. 'lb remove this restriction we developed in this project graphical modeling techniques based on rank correlation matrix. The method was applied for studying joint risks of environmental contaminants such as Dioxin, PCB and pesticides measuring the amount of these chemicals in breast milks of 120 women and also measuring the thyroid and immune hormone status of infants from those mothers. It was discovered by the method that the odds ratios of thyroid function and Dioxin was 1.65 (p=0.29), but was 7.15 (p=0.02) when adjusted for PCB.
We further developed a method of graphical modeling technique that used latent structure models, and also explored the method that may deal with time series data.
Theoretical studies were conducted to develop those methods mentioned above ; namely
(i)Developed estimation and testing method for comparing two negative binomial distributions by adjusting for confounding variables by stratification.
(ii)Developed a method of nonparametric imputation.
(iii) Developed a theory to extract information from high dimensional data by modeling the data using various base functions ; developed a Bayes Information criteria to select the models; applied it to not only the graphical modeling but also other statistical methods such as disiminant analysis for DNA data and others.
(iv)Developed a theory of graphical modeling for repeated measurements data in one to K multiple comparison setting and developed an approximate confidence intervals for the parameters involved.
(v)Developed theory for estimating unknown drift parameter and diffusion parameter of the diffusion process with small diffusion and proved their consisitency and asymptotic normality.
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[Journal Article] Effects of lactational exposure to organochlorine pesticides, PCBs and dioxins on immune response and thyroid hormone systems in 10-month-old Japanesk male and female infants2004
Author(s)
J.Nagayama, H.Tsuji, T.Iida, R.Nakagawa, T.Matsueda, H.Hirakawa, A.Shiraha, T.Yanagawa, J.Fukushige, T.Watanabe
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Journal Title
Organohalogen Compounds 66
Pages: 3217-3223
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effects of PCDDs, PCDFs and coplanar PCBs on immune response and thyroid hormone systems in Japanese mothers2003
Author(s)
J.Nagayama, H.Tsuji, T.Iida, R.Nakagawa, T.Matsueda, H.Hirakawa, A.Shiraha, T.Yanagawa, J.Fukushige, T.Watanabe
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Journal Title
Organohalogen Compounds 63
Pages: 393-396
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Sexual distinction in effects of perinatal exposure to organochlorine pesticides, PCBs and dioxins on immune response and thyroid hormone systems in Japanese infants2003
Author(s)
J.Nagayama, H.Tsuji, T.Iida, R.Nakagawa, T.Matseda, H.Hirakawa, A.Shiraha, T.Yanagawa, J.Fukushige, T.Watanabe
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Journal Title
Organohalogen Compounds 65
Pages: 190-194
Description
「研究成果報告書概要(欧文)」より
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[Book] 情報量基準2004
Author(s)
小西貞則, 北川源四郎(共著)
Total Pages
194
Publisher
朝倉書店
Description
「研究成果報告書概要(和文)」より
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[Book] 統計科学の最前線2003
Author(s)
柳川 堯(編著)
Total Pages
178
Publisher
九州大学出版会
Description
「研究成果報告書概要(和文)」より
