2005 Fiscal Year Final Research Report Summary
ADP-ribosyl cyclase coupled with dopamine receptors : Application to Parkinson's disease
| Project/Area Number |
15300124
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kanazawa University |
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Principal Investigator |
HIGASHIDA Haruhiro Kanazawa University, Dept.of Biophysical Genetics, Professor, 医学系研究科, 教授 (30093066)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA S. Kanazawa University, Dept.of Biophysical Genetics, Associate Professor, 医学系研究科, 助教授 (00210633)
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| Project Period (FY) |
2003 – 2005
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| Keywords | Cyclic ADP-ribose / CD38 / NAD^+ / NG108-15 cells / Striatum / Dopamine / Dopamine receptor |
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| Research Abstract |
We examined the role of cyclic ADP-ribose (cADPR) as a second messenger downstream of receptors in the striatal cortex and NG108-15 cells. To address this question, ADP-ribosyl cyclase activity was measured in a crude membrane fraction of rat striatum and NG108-15 cells transfected with CD38. Dopamine (DA) stimulated the cyclase activity. The cyclase activity in overexpressed cells had various effects on neuronal function. The following two reports are the summary of the cADPR function written in a review form (7-2) and research report on CD38 transfection (7-3)
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[Journal Article] Synthesis of stable and cell-type selective analogues of cyclic ADP-ribose, a Ca(2+)-mobilizing second messenger. Structure--activity relationship of the N1-ribose moiety.2005
Author(s)
Kudoh T, Fukuoka M, Ichikawa S, Murayama T, Ogawa Y, Hashii M, Higashida H, Kunerth S, Weber K, Guse AH, Potter BV, Matsuda A, Shuto S.
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Journal Title
Am Chem Soc. 127
Pages: 8846-8855
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Synthesis of stable and cell-type selective analogues of cyclic ADP-ribose, a Ca(2+)-mobilizing second messenger. Structure-activity relationship of the N1-ribose moiety.2005
Author(s)
Kudoh T, Fukuoka M, Ichikawa S, Murayama T, Ogawa Y, Hashii M, Higashida H, Kunerth S, Weber K, Guse AH, Potter BV, Matsuda A, Shuto S.
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Journal Title
J Am Chem Soc. 127
Pages: 8846-8855
Description
「研究成果報告書概要(欧文)」より
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