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2004 Fiscal Year Final Research Report Summary

Regulation of angiogenesis-related diseases by conjugated trienoic acids, tocotrienol and amadori-glycated phospholipids.

Research Project

Project/Area Number 15380086
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionTohoku University

Principal Investigator

MIYAZAWA Teruo  Tohoku University, Graduate School of Agricultural Science, professor, 大学院・農学研究科, 教授 (20157639)

Co-Investigator(Kenkyū-buntansha) YAMASITA Mari  Tohoku University, Graduate School of Agricultural Science, professor, 大学院・農学研究科, 教授 (50192430)
Project Period (FY) 2003 – 2004
Keywordsangiogenesis inhibition / conjugated trienoic fatty acid / tocotrienol / glycated phosphatidylethanolamine / cancer / atherosclerosis / diabetic retinopathy / vascular endothelial cells
Research Abstract

Angiogenesis is the process of generating new capillary blood vessels, involving proliferation of endothelial cells, cell migration, and capillary tube formation. Abnormal angiogenesis relates to intractable diseases such as cancer, diabetic retinopathy atherosclerosis, and arthritis. Therefore, the present, interestingly, the inhibition of angiogenesis is one of the most attractive approaches for prevention of these diseases. Moreover, regulation of angiogenesis by foods and food components is becoming an important issue.
Our previous researches have shown that conjugated trienoic fatty acid and tocotrienol can inhibit angiogenesis more effectively than some medicinal drugs. Moreover, we have proved the presence of Amadori glycated phosphatidylethanolamine, a lipid-linked glycation compound, as accelerator of angiogenesis.
In this study, 1)conjugated trienoic fatty acids were fed to nude mice with transplant of tumor cells and antitumor mechanism and anti-angiogenesis activity of conjugated trienoic fatty acids were investigated. 2)The anti-angiogenic mechanism of tocotrienol, a natural analog of tocopherol, was investigated both in vitro and in vivo. 3)The stimulation of angiogenesis by glycated phosphatidylethanolamine was investigated by using cultured cells, food components that can inhibit glycation of phospholipids were screened.
Based on these present knowledge, foods and food components that can prevent angiogenic disorders diseases such as cancer, diabetic retinopathy atherosclerosis and arthritis will be effectively developed.

  • Research Products

    (17 results)

All 2004 2003 2002

All Journal Article (16 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Anti-angiogenic potential of tocotrienol in vitro.2004

    • Author(s)
      T.Miyazawa H.Inokuchi, H.Hirokane, T.Tsuzuki, K Nakagawa, M.Igarashi
    • Journal Title

      Biochemistry (Mosc) 69

      Pages: 67-69

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Conjugated eicosapentanoic acid inhibits transplanted tumor growth via membrane lipid peroxidation in nude mice.2004

    • Author(s)
      T.Tsuzuki, M.Igarashi, T.Miyazawa
    • Journal Title

      J.Nutr. 134

      Pages: 1162-1166

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Tumor growth suppression by a-eleostearic acid, a linolenic acid isomer with a conjugated triene system, via lipid peroxidation.2004

    • Author(s)
      T.Tsuzuki, Y.Tokuyama, M.Igarashi, T.Miyazawa
    • Journal Title

      Carcinogenesis 25

      Pages: 1417-1425

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Antiagiogenic potency of vitamin E.2004

    • Author(s)
      T.Miyazawa, T.Tsuzuki, K.Nakagawa, M.Igarashi
    • Journal Title

      Ann N Y Acad Sci. 1031

      Pages: 401-404

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] DNA chip analysis of comprehensive food function : Inhibition of angiogenesis and telomerase activity with unsaturated vitamin E, tocotrienol.2004

    • Author(s)
      K.Nakagawa, T.Eitsuka, H.Inokuchi, T.Miyazawa
    • Journal Title

      Biofactors. 21

      Pages: 5-10

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Anti-angiogenic potential of tocotrienol in vitro.2004

    • Author(s)
      T.Miyazawa, H.Inokuchi H.Hirokane, T.Tsuzuki, K.Nakagawa, M.Igarashi
    • Journal Title

      Biochemistry (Moscow) 69

      Pages: 67-69

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Anti-angiogenic potential of tocotrienol in vitro.2004

    • Author(s)
      T.Miyazawa, H.Inokuchi, H.Hirokane, T.Tsuzuki, K.Nakagawa, M.Igarashi.
    • Journal Title

      Biochemistry (Mosc). 69

      Pages: 67-69

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Tumor growth suppression by α-eleostearic acid, a linolenic acid isomer with a conjugated triene system, via lipid peroxidation.2004

    • Author(s)
      T.Tsuzuki, Y.Tokuyama, M.Igarashi, T.Miyazawa
    • Journal Title

      Carcinogenesis 25

      Pages: 1417-1425

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Antiangiogenic potency of vitamin E.2004

    • Author(s)
      T.Miyazawa, T.Tsuzuki, K.Nakagawa, M.Igarashi
    • Journal Title

      Ann.N.Y. Acad.Sci. 1031

      Pages: 401-404

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] DNA chip analysis of comprehensive food function : Inhibition of angiogenesis and telomerase activity with unsaturated vitamin E, tocotrienol.2004

    • Author(s)
      K.Nakagawa, T.Eitsuka, H.Inokuchi, T.Miyazawa
    • Journal Title

      Biofactors 21

      Pages: 5-10

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Anti-angiogenic potential of tocotrienol in vitro.2004

    • Author(s)
      T.Miyazawa, H.Inokuchi, H.Hirokane, T.Tsuzuki, K.Nakagawa, M.Igarashi
    • Journal Title

      Biochemistry (Moscow) 69

      Pages: 67-69

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Amadori-glycated phosphatidylethanolamine induces angiogenic differentiations in cultured human umbilical vein endothelial cells.2003

    • Author(s)
      J.-H.Oak, K.Nakagawa, S.Oikawa, T.Miyazawa
    • Journal Title

      FEBS Lett. 555

      Pages: 419-423

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Anti-angiogenic activity of tocotrienol.2003

    • Author(s)
      H.Inokuchi, H.Hirokane, T.Tsuzuki, K.Nakagawa, M.Igarashi, T.Miyazawa
    • Journal Title

      Biosci.Biotechnol.Biochem 67

      Pages: 1623-1627

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The metabolic conversion of 9,11,13-eleostearic acid (18:3) to 9,11-conjugated linoleic acid (18:2) in the rat.2003

    • Author(s)
      T.Tsuzuki, M.Igarashi, M.Komai, T.Miyazawa
    • Journal Title

      J.Nutr.Sci.Vitaminol. 49

      Pages: 195-200

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Amadori-glycated phosphatidylethanolamine induces angiogenic differentiations in cultured human umbilical vein endothelial cells.2003

    • Author(s)
      J.H.Oak, K.Nakagawa, S.Oikawa, T.Miyazawa
    • Journal Title

      FEBS Lett. 555

      Pages: 419-423

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Anti-angiogenic activity of tocotrienol.2003

    • Author(s)
      H.Inokuchi, H.Hirokane, T.Tsuzuki, K.Nakagawa, M.Igarashi, T.Miyazawa
    • Journal Title

      Biosci.Biotechnol.Biochem. 67

      Pages: 1623-1627

    • Description
      「研究成果報告書概要(欧文)」より
  • [Patent(Industrial Property Rights)] Inhibition for neovasculation, cell multiplication, lumen formation and FGF,2002

    • Inventor(s)
      T.Miyazawa et al.
    • Industrial Property Rights Holder
      T.Miyazawa et al.
    • Industrial Property Number
      US Patent No.US6,608,103 B2
    • Filing Date
      2002-02-01
    • Acquisition Date
      2003-08-19
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2006-07-11  

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