2005 Fiscal Year Final Research Report Summary
Studies on Involvement of Mex Efflux Systems of Pseudomonas aeruginosa on Antimicrobial Resistance and Virulence
| Project/Area Number |
15390146
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
GOTOH Naomasa Kyoto Pharmaceutical University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (30121560)
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| Co-Investigator(Kenkyū-buntansha) |
NISHINO Takeshi Kyoto Pharmaceutical University, Professor, 薬学部, 教授 (50097838)
OGAWA Michihiro Kyoto Pharmaceutical University, Research Associate, 薬学部, 助手 (00411033)
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| Project Period (FY) |
2003 – 2005
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| Keywords | Pseudomonas aeruginosa / Efflux system / Antimicrobial resistance / virulence / Disk Diffusion assay / Quorum sensing system |
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| Research Abstract |
A bacterial RND efflux system plays a important role on resistance to antimicrobial agents of gram-negative bacteria. However, it has been continued that "What is a originally physiological function of bacterial efflux systems, rather than resistance to the antimicrobial agents" is asked at the same time though researches of the resistance in a pathogenic gram-negative bacteria. The answer to it is being obtained now. One is the self-defense from xenobiotics including antimicrobial agents, disinfectants, organic solvents and heavy metals that exists in the growth environment, and another one is etrusion of the autoinducer that functions to intracellular cell-to-cell communications. The efflux system research has come to see the link of mechanisms like the antimicrobial resistance and the pathogenicity, not originally related.
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