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2005 Fiscal Year Final Research Report Summary

Molecular mechanism whereby Type I interferon is induced in host immune cells by measles virus infection : possible involvement of Toll-like receptors (TLRs)

Research Project

Project/Area Number 15390154
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Virology
Research InstitutionHOKKAIDO UNIVERSITY (2004-2005)
Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses (2003)

Principal Investigator

SEYA Tsukasa  Hokkaido Univ., Grad.School of Med., Professor, 大学院・医学研究科, 教授 (10301805)

Co-Investigator(Kenkyū-buntansha) MATSUMOTO Misako  Hokkaido Univ., Grad.School of Med., Asso.Professor, 大学院・医学研究科, 助教授 (30332456)
Project Period (FY) 2003 – 2005
KeywordsMeasles virus / TLR3 / dendritic cell / dsRNA / CD46 / SLAM / IRE-3 / IFN-β
Research Abstract

TLR3 fosters the induction of type I interferon (IFN) in myeloid dendritic cells (mDCs) in response to exogenously-added dsRNA. Recently, CARD-helicase family proteins, RIG-I and MDA5, are found to be involved in recognition of cytoplasmic dsRNA, presumably of viral origin. Thus, through these sensor molecules virus infection culminates in IFN response. In this study, we have identified the adapter molecule of TLR3 that induces IFN-β and named TICAM-1 (also called Trif). We established CD46/CD150 double TG mice and performed measles infection studies using the TG mice. The TG mice were not measles-sensitive until the IFNAR gene was simultaneously disrupted in addition to the TG. CD11c-positive mDCs were engaged in establishing the initial infection with measles virus. What are the role of TLR3 in mDCs during measles infection and their relation to immune suppression are currently under investigation.

  • Research Products

    (70 results)

All 2006 2005 2004 2003 Other

All Journal Article (70 results)

  • [Journal Article] A novel cyclohexene derivative, TAK-242, selectively inhibits Toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling.2006

    • Author(s)
      Ii, M., Seya T., et al.
    • Journal Title

      Mol Pharmacol. 69

      Pages: 1288-1295

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Physical and functional interactions between STAT3 and Kaposi's sarcoma-associated herpesvirus-encoded LANA.2006

    • Author(s)
      Muromoto, R., Seya T., et al.
    • Journal Title

      FEBS Lett. 580

      Pages: 93-98

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] IRAK-4-dependent phosphorylation and ubiquitination of 1RAK-1 is a negative feedback signal for TLR-mediated NF-κ B activation.2006

    • Author(s)
      Murai, M., Seya T., et al.
    • Journal Title

      FEBS J. (in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Protein kinase Cd associates TIRAP/Mal and regulates NF-kB and mitogen-activated protein kinases in Toll-like receptor signaling.2006

    • Author(s)
      Sukenobu, N., Seya T., et al.
    • Journal Title

      J. Immunol. (in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Inhibition of the TLR pathway for interferon-beta induction by soluble G protein of respiratory syncytial virus.2006

    • Author(s)
      Shingai, M., Seya T., et al.
    • Journal Title

      J. Immunol. (submitted)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] NAP1 (NAK-associated protein 1) participates in both the TLR3 and he cytoplasmic pathways in type I interferon induction.2006

    • Author(s)
      Sasai, M., Seya T., et al.
    • Journal Title

      J. Immunol. (submitted)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Toll-like receptor 3-mediated eotaxin-1 release from human bronchial smooth muscle cells.2006

    • Author(s)
      IViimi, K., Seya, T., et al.
    • Journal Title

      J. Immunol. (in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Differential gene-inducing programs induced by polyl : C and measles virus infection.2006

    • Author(s)
      Shingai, M., Seya T., et al.
    • Journal Title

      Int. Immunol. (submitted)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The Kinase Complex Responsible for IRF-3-Mediated IFN-{beta} Production in Myeloid Dendritic Cells (mDC).2006

    • Author(s)
      Sasai, M., Seya, T., et al.
    • Journal Title

      J. Biochem (Tokyo) (review) 139

      Pages: 171-175

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Role of Toll-like receptors in adjuvant-augmented immune therapies.2006

    • Author(s)
      Seya, T., et al.
    • Journal Title

      eCAM. (review) 3

      Pages: 31-38

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Toll-like receptors in lower vertebrates.2006

    • Author(s)
      Seya T., et al.
    • Journal Title

      Comprehensive Glycoscience. (review) (in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] A novel cyclohexene derivative, TAK-242, selectively inhibits Toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling.2006

    • Author(s)
      Ii, M., Seya, T., et al.
    • Journal Title

      Mol Pharmacol. 69

      Pages: 1288-1295

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Physical and functional interactions between STAT3 and Kaposi's sarcoma-associated herpesvirus-encoded LANA.2006

    • Author(s)
      Muromoto, R., Seya, T., et al.
    • Journal Title

      FEBS Lett. 580

      Pages: 93-98

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] IRAK-4-dependent phosphorylation and ubiquitination of IRAK-1 is a negative feedback signal for TLR-mediated NF-κB activation.2006

    • Author(s)
      Murai, M., Seya, T., et al.
    • Journal Title

      FEBS J. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Inhibition of the TLR pathway for interferon-beta induction by soluble G protein of respiratory syncytial virus.2006

    • Author(s)
      Shingai, M., Seya T., et al.
    • Journal Title

      J.Immunol. (submitted)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] NAP1 (NAK-associated protein 1) participates in both the TLR3 and the cytoplasmic pathways in type 1 interferon induction.2006

    • Author(s)
      Sasai, M., Seya T., et al.
    • Journal Title

      J.Immunol. (submitted)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Toll-like receptor 3-mediated eotaxin-1 release from human bronchial smooth muscle cells.2006

    • Author(s)
      Niimi, K., Seya, T., et al.
    • Journal Title

      J.Immunol. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Differential gene-inducing programs induced by polyl : C and measles virus infection.2006

    • Author(s)
      Shingai, M., Seya, T., et al.
    • Journal Title

      Int.Immunol. (submitted)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The Kinase Complex Responsible for IRF-3-Mediated IFN-{beta} Production in Myeloid Dendritic Cells (mDC).2006

    • Author(s)
      Sasai, M., Seya, T., et al.
    • Journal Title

      J.Biochem (Tokyo) 139(review)

      Pages: 171-175

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Role of Toll-like receptors in adjuvant-augmented immune therapies2006

    • Author(s)
      Seya, T., et al.
    • Journal Title

      eCAM. 3(review)

      Pages: 31-38

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Toll-like receptors in lower vertebrates.2006

    • Author(s)
      Seya, T., et al.
    • Journal Title

      Comprehensive Glycoscience (in press)(review)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cutting Edge : NF- κ B-activating kinase-associate protein 1participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN Regulatory Factor 3 activation.2005

    • Author(s)
      Sasai, M., Seya, T., et al.
    • Journal Title

      J. Immunol. 174

      Pages: 27-30

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Surface-expressed TLR 6 Participates in the Recognition of Diacylated Lipopeptide and Peptidoglycan in Human Cells.2005

    • Author(s)
      Nakao, Y., Seya, et al.
    • Journal Title

      J. Immunol. 174

      Pages: 1566-1573

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Gene-inducing program of human dendritic cells in response to BCG ce11-wall skeleton (CWS), which reflects adjuvancy required for tumor immunotherapy.2005

    • Author(s)
      Ishii, K., Seya, T., et al.
    • Journal Title

      J Immunol. Lett. 98

      Pages: 280-290

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Pathways participating in activation of mouse uterine natural killer cells during pregnancy.2005

    • Author(s)
      Xie, X., Seya, T., et al.
    • Journal Title

      Biol. Reprod. 73

      Pages: 510-518

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Wild-type measles virus infection in human CD46/CD150-trangenic mice : CD11c-positive dendritic establish systemic viral infection.2005

    • Author(s)
      Shingai, M., Seya, T., et al.
    • Journal Title

      J. Immunol. 175

      Pages: 3252-3261

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Interferon-β induction through Toll-like receptor 3 depends on double-stranded RNA structure.2005

    • Author(s)
      Okahira, S., Seya T., et al.
    • Journal Title

      DNA Cell Biol. 24

      Pages: 614-623

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Differential-expression and tyrosine-phosphorylation profiles of caveolin isoforms in human T cell leukemia cell lines.2005

    • Author(s)
      Tsuji, Y., Seya, T., et al.
    • Journal Title

      Int J Mol Med. 16

      Pages: 889-893

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Anti-tumor natural killer cell activation induced by spirulina extract.2005

    • Author(s)
      Masuda, H., Seya T., et al.
    • Journal Title

      Int. Immunopharmacology (submitted)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Antibodies against human Toll-like receptors (TLRs) : TLR distribution and localization in human dendritic cells.2005

    • Author(s)
      Seya, T., et al.
    • Journal Title

      J. Endotoxin Res. (review)

      Pages: 369-374

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Molecules in Focus : TICAM-1 and TICAM-2 : Toll-like receptor adapters that participate in induction of type 1 interferons.2005

    • Author(s)
      Seya, T., et al.
    • Journal Title

      Int. J. Biochem. Cell Biol. (review) 37

      Pages: 524-529

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cutting Edge : NF-κ B-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN Regulatory Factor 3 activation.2005

    • Author(s)
      Sasai, M., Seya, T., et al.
    • Journal Title

      J.Immunol. 174

      Pages: 27-30

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Surface-expressed TLR 6 Participates in the Recognition of Diacylated Lipopeptide and Peptidoglycan in Human Cells.2005

    • Author(s)
      Nakao, Y., Seya, T., et al.
    • Journal Title

      J.Immunol. 174

      Pages: 1566-1573

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Gene-inducing program of human dendritic cells in response to BCG cell-wall skeleton (CWS), which reflects adjuvancy required for tumor immunotherapy.2005

    • Author(s)
      Ishii, K., Seya, T., et al.
    • Journal Title

      Immunol.Lett. 98

      Pages: 280-290

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Pathways participating in activation of mouse uterine natural killer cells during pregnancy.2005

    • Author(s)
      Xie, X., Seya, T., et al.
    • Journal Title

      Biol.Reprod 73

      Pages: 510-518

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Wild-type measles virus infection in human CD46/CD150-trangenic mice : CD11c-positive dendritic establish systemic viral infection.2005

    • Author(s)
      Shingai, M., Seya, T., et al.
    • Journal Title

      J.Inimunol. 175

      Pages: 3252-3261

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Interferon-β induction through Toll-like receptor 3 depends on double-stranded RNA structure.2005

    • Author(s)
      Okahira, S., Seya, T., et al.
    • Journal Title

      DNA Cell Biol. 24

      Pages: 614-623

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Differential-expression and tyrosine-phosphorylation profiles of caveolin isoforms in human T cell leukemia cell lines.2005

    • Author(s)
      Tsuji, Y., Seya T., et al.
    • Journal Title

      Int J Mol Med. 16

      Pages: 889-893

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Anti-tumor natural killer cell activation induced by spirulina extract.2005

    • Author(s)
      Masuda, H., Sea T., et al.
    • Journal Title

      Int.Immunopharmacology (submitted)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Antibodies against human Toll-like receptors (TLRs) : TLR distribution and localization in human dendritic cells.2005

    • Author(s)
      Seya, T., et al.
    • Journal Title

      J.Endotoxin Res. 11(review)

      Pages: 369-374

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Molecules in Focus : TICAM-1 and TICAM-2 : Toll-like receptor adapters that participate in induction of type 1 interferons.2005

    • Author(s)
      Seya, T., et al.
    • Journal Title

      Int.J.Biochem.Cell Biol. 37(review)

      Pages: 524-529

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Infection of different cell lines of neural origin with subacute sclerosing panencephalitis (SSPE) virus.2004

    • Author(s)
      T Ishida, H., Seya, T., et al.
    • Journal Title

      Microbiol. Immunol. 48

      Pages: 277-287

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling.2004

    • Author(s)
      Funami, K., Seya, T., et al.
    • Journal Title

      Int. Immunol. 16

      Pages: 1143-54

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Toll-like Receptor, 3; A Link between Toll-like Receptor, Interferon and Viruses.2004

    • Author(s)
      Matsumoto, M., Seya, T., et al.
    • Journal Title

      Microbiol. Immunol. (review) 48

      Pages: 147-154

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Differential maturation of dendtitic cells by TLR adapters : application to immunotherapy. Cancer Immunotherapy Ed. By K. Toyoshima, J. C. Banett, E. Klein, Y. Hashimoto, and H. Wakasugi. Princess Takamatsu Cancer Research Fund.2004

    • Author(s)
      Seya T., et al.
    • Journal Title

      Princess Takamatsu Symposia 34

      Pages: 12-15

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Toll-like receptor 2 agonists with unique properties synthesized with reference to a product of Streptosporsngium.2004

    • Author(s)
      Matsuo-Tanabe, M., Seya T., et al.
    • Journal Title

      Immunology 2004

      Pages: 235-241

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Infection of different cell lines of neural origin with subacute sclerosing panencephalitis (SSPE) virus.2004

    • Author(s)
      Ishida, H., Seya, T., et al.
    • Journal Title

      Microbiol.Immunol 48

      Pages: 277-287

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling.2004

    • Author(s)
      Funami, K., Seya, T., et al.
    • Journal Title

      Int.Immunol. 16

      Pages: 1143-1154

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Toll-like Receptor 3 : A Link between Toll-like Receptor, Interferon and Viruses.2004

    • Author(s)
      Matsumoto, M., Seya, T., et al.
    • Journal Title

      Microbiol.Immunol. 48(review)

      Pages: 147-154

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Differential maturation of dendritic cells by TLR adapters : application to immunotherapy. Cancer Immunotherapy2004

    • Author(s)
      Seya, T., et al.
    • Journal Title

      Princess Takamatsu Symposia (Ed. By K.Toyoshima, J.C.Barrett, E.Klein, Y.Hashimoto, and H.Wakasugi.) (Princess Takamatsu Cancer Research Fund.) 34

      Pages: 12-15

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Toll-like receptor 2 agonists with unique properties synthesized with reference to a product of Streptosporangium.2004

    • Author(s)
      Matsuo-Tanabe, M., Seya, T., et al.
    • Journal Title

      Immunology 2004

      Pages: 235-241

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways.2003

    • Author(s)
      Hazeki, K., Seya, T., et al.
    • Journal Title

      Eur. J. Immunol. 33

      Pages: 740-747

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Disruption of the mouse CD46 causes an accelerated spontaneousacrosome reaction in sperm.2003

    • Author(s)
      Inoue, N., Seya, T., et al.
    • Journal Title

      Molec. Cell. Biol. 23

      Pages: 2614-2622

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] TICAM-1, an adapter molecule that participates in Toll-like receptor3-mediated interferon-beta induction.2003

    • Author(s)
      Oshiumi, H., Se a T., et al.
    • Journal Title

      Nature Imrnunol. 4

      Pages: 161-167

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Down-regulation of TolHike receptor expression in monocyte- eriveLangerhans cell-like cells : implications of low-responsiveness tobacterial_components in the epidermal Langerhans cells.2003

    • Author(s)
      Takeuchi, J., Seya, T., et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 306

      Pages: 674-679

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Receptor use by vesicular stomatitis virus ~seu ofypes withlycoproteins of defective variants of measles virus isolated frombrains of patients with subacute sclerosing panencephalitis.2003

    • Author(s)
      Shingai, M., Seya, T., et al.
    • Journal Title

      J. Gen. Virol. 84

      Pages: 2133-2143

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Subcellular localization of Toll-like receptor 3 in human dendriticcells.2003

    • Author(s)
      Matsumoto, M., Seya, T., et al.
    • Journal Title

      J. Immunol. 171

      Pages: 3154-3162

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] T1R-containing adapter molecule(T1CAM)-2 a bridigng adapter recruiting to Toll-like receptor 4 T1CAM-1 that inducesinterferon-beta.2003

    • Author(s)
      Oshiumi, H., Seya, T., et al.
    • Journal Title

      J Biol. Chem. 278

      Pages: 49751-49762

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Mechanism of up-regulation of human Toll-like receptor 3 secondary to infection of measles virus-attenuated strains.2003

    • Author(s)
      Tanabe, M., Seya, T., et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 311

      Pages: 39-48

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Selective contribution of IFN- a/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infectin.2003

    • Author(s)
      Honda, K., Seya, T., et al.
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 100

      Pages: 10872-10877

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways.2003

    • Author(s)
      Hazeki, K., Seya, T., et al.
    • Journal Title

      Eur.J.Immunol 33

      Pages: 740-747

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Disruption of the mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm.2003

    • Author(s)
      Inoue, N., Seya, T., et al.
    • Journal Title

      Molec.Cell.Biol. 23

      Pages: 2614-2622

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] TICAM-1, an adapter molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.2003

    • Author(s)
      Oshiumi, H., Seya, T., et al.
    • Journal Title

      Nature Immunol. 4

      Pages: 161-167

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Down-regulation of Toll-like receptor expression in monocyte-derived Langerhans cell-like cells : implications of low-responsiveness to bacterial components in the epiderml Langerhans cells.2003

    • Author(s)
      Takeuchi, J., Sea T., et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 306

      Pages: 674-679

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Receptor use by vesicular stomatitis virus pseudotypes with glycoproteins of defective variants of measles virus isolated from brains of patients with subacute sclerosing panencephalitis.2003

    • Author(s)
      Shingai, M., Seya, T., et al.
    • Journal Title

      J.Gen.Virol. 84

      Pages: 2133-2143

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Subcellular localization of Toll-like receptor 3 in human dendritic cells.2003

    • Author(s)
      Matsumoto, M., Seya, T., et al.
    • Journal Title

      J.Immunol. 171

      Pages: 3154-3162

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] TIR-containing adapter molecule(TICAM)-2, a bridging adapter recruiting to Toll-like receptor 4 TICAM-1 that induces interferon-beta.2003

    • Author(s)
      Oshiumi, H., Seya, T., et al.
    • Journal Title

      J.Biol.Chem. 278

      Pages: 49751-49762

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Mechanism of up-regulation of human Toll-like receptor 3 secondary to infection of measles virus-attenuated strains.2003

    • Author(s)
      Tanabe, M., Seya T., et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 311

      Pages: 39-48

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Selective contribution of IFN-α/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infectin.2003

    • Author(s)
      Honda, K., Seya, T., et al.
    • Journal Title

      Proc.Natl.Acad.Sci.USA. 100

      Pages: 10872-10877

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Protein kinase Cd associates TIRAP/Mal and regulates NF-κB and mitogen-activated protein kinases in Toll-like receptor signaling.

    • Author(s)
      Sukenobu, N., Seya T., et al.
    • Journal Title

      J.Immunol. (in press)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2007-12-13  

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