• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2005 Fiscal Year Final Research Report Summary

Pharmacological investigation for mechanisms of cerebral hemorrhage induced by anti-thrombotic agents

Research Project

Project/Area Number 15390173
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

UMEMURA Kazuo  Hamamatsu University School of Medicine, Professor, 医学部, 教授 (40232912)

Co-Investigator(Kenkyū-buntansha) SUZUKI Yasuhiro  Hamamatsu University School or Medicine, Assistant Professor, 医学部, 助手 (00324343)
Project Period (FY) 2003 – 2005
Keywordsstroke / cerebral hemorrhage / heparin / tPA / MMP-9
Research Abstract

Cerebral hemorrhage associated with antithrombotic and thrombolytic therapy in acute stroke is a major clinical problem. We investigated the roles of endogenous tPA and MMPs in hemorrhagic cerebral infarction associated with heparin. We demonstrated that heparin administration caused cerebral hemorrhage in WT but not in KO. Heparin administration increased tPA activity and its mRNA expression in WT. We also observed an induction of MMP9 and its mRNA expression by heparin administration in WT but not in KO. Our findings suggest that endogenous tPA plays an important role in heparin-produced cerebral hemorrhage via MMP9 induction and activation.

URL: 

Published: 2007-12-13  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi