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2005 Fiscal Year Final Research Report Summary

Integrated system of the tailor-made cancer treatment based on the expression profiling and bioinformatic analyses

Research Project

Project/Area Number 15390181
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionNagoya University (2004-2005)
Aichi Cancer Center Research Institute (2003)

Principal Investigator

TAKAHASHI Takashi  Nagoya University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (50231395)

Co-Investigator(Kenkyū-buntansha) YANAGISAWA Kiyoshi  Nagoya University, Graduate School of Medicine, Research Associate, 大学院・医学系研究科, 助手 (20372112)
TOMIDA Shuta  Nagoya University, Graduate School of Medicine, Research Fellow, 大学院・医学系研究科, 研究機関研究員 (10372111)
MITSUDOMI Tetsuya  Research Institute, Aichi Cancer Center, Researcher, 分子腫瘍学部, 研究員 (70209807)
HIDA Toyoaki  Research Institute, Aichi Cancer Center, Researcher, 分子腫瘍学部, 研究員 (80250249)
YATABE Yasushi  Research Institute, Aichi Cancer Center, Researcher, 分子腫瘍学部, 研究員 (90280809)
Project Period (FY) 2003 – 2005
KeywordsExpression profiling / Microarray / Bioinformatics / Proteomics / Mass spectrometry
Research Abstract

In this study, we have carried out highly sophisticated genomics and proteomics analyses of surgically resected cases of lung cancer, which has been the number one cause of cancer deaths in Japan, in order to establish the foundation for the integrated system of the tailor-made cancer treatment. As a result, we were able to show the presence of expression-profile-defined heterogeneity of pulmonary adenocarcinomas, which appeared to be correlated well with the status of genetic alterations and postoperative clinical behaviors such as prognosis. Furthermore, the newly proposed classification could distinguish a subset of patients, which most likely benefit from adjuvant molecular targeted therapy against EGFR-mediated signaling. In addition, we were able to establish the foundation for future studies on the applied proteomics of blood specimens such as serum. These findings should aid further development of genomics and/or proteomics-based approach towards the tailor-made medicine to conquer this devastating illness.

  • Research Products

    (8 results)

All 2006 2005 Other

All Journal Article (7 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Altered regulation of c-jun and its involvement in anchorage-independent growth of human lung cancers.2006

    • Author(s)
      Maeno, K., et al.
    • Journal Title

      Oncogene 25

      Pages: 271-277

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Polycistronic miRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation.2005

    • Author(s)
      Hayashita, Y., et al.
    • Journal Title

      Cancer Research 65

      Pages: 9628-9632

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features.2005

    • Author(s)
      Osada, H., et al.
    • Journal Title

      Cancer Research 65

      Pages: 10680-10685

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Histone modification in the TGFβRII gene promoter and its significance for responsiveness to HDAC inhibitor in lung cancer cell lines.2005

    • Author(s)
      Osada, H., et al.
    • Journal Title

      Molecular Carcinogenesis 44

      Pages: 233-241

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Reduced expression of Dicer associated with poor prognosis in lung cancer patients.2005

    • Author(s)
      Karube, Y., et al.
    • Journal Title

      Cancer Science 96

      Pages: 111-115

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors.

    • Author(s)
      Takeuchi, T., et al.
    • Journal Title

      Journal of Clinical Oncology (in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors.

    • Author(s)
      Takeuchi, T., et al.
    • Journal Title

      Journal of Clinical Oncology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Patent(Industrial Property Rights)] 肺腺癌患者の術後予後を予想するための方法及び組成物2005

    • Inventor(s)
      高橋隆, 他
    • Industrial Property Rights Holder
      名古屋大学及び愛知県
    • Industrial Property Number
      特願2005-291588
    • Filing Date
      2005-10-04
    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 2007-12-13  

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