2005 Fiscal Year Final Research Report Summary
Integrated system of the tailor-made cancer treatment based on the expression profiling and bioinformatic analyses
| Project/Area Number |
15390181
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Nagoya University (2004-2005)
Aichi Cancer Center Research Institute (2003) |
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Principal Investigator |
TAKAHASHI Takashi Nagoya University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (50231395)
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| Co-Investigator(Kenkyū-buntansha) |
YANAGISAWA Kiyoshi Nagoya University, Graduate School of Medicine, Research Associate, 大学院・医学系研究科, 助手 (20372112)
TOMIDA Shuta Nagoya University, Graduate School of Medicine, Research Fellow, 大学院・医学系研究科, 研究機関研究員 (10372111)
MITSUDOMI Tetsuya Research Institute, Aichi Cancer Center, Researcher, 分子腫瘍学部, 研究員 (70209807)
HIDA Toyoaki Research Institute, Aichi Cancer Center, Researcher, 分子腫瘍学部, 研究員 (80250249)
YATABE Yasushi Research Institute, Aichi Cancer Center, Researcher, 分子腫瘍学部, 研究員 (90280809)
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| Project Period (FY) |
2003 – 2005
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| Keywords | Expression profiling / Microarray / Bioinformatics / Proteomics / Mass spectrometry |
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| Research Abstract |
In this study, we have carried out highly sophisticated genomics and proteomics analyses of surgically resected cases of lung cancer, which has been the number one cause of cancer deaths in Japan, in order to establish the foundation for the integrated system of the tailor-made cancer treatment. As a result, we were able to show the presence of expression-profile-defined heterogeneity of pulmonary adenocarcinomas, which appeared to be correlated well with the status of genetic alterations and postoperative clinical behaviors such as prognosis. Furthermore, the newly proposed classification could distinguish a subset of patients, which most likely benefit from adjuvant molecular targeted therapy against EGFR-mediated signaling. In addition, we were able to establish the foundation for future studies on the applied proteomics of blood specimens such as serum. These findings should aid further development of genomics and/or proteomics-based approach towards the tailor-made medicine to conquer this devastating illness.
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