• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2005 Fiscal Year Final Research Report Summary

Gene expression and gene polymorphisms related with chole-pancreatic diseases

Research Project

Project/Area Number 15390237
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionTokyo Metropolitan Foundation of Research on Aging and Promotion of Human Welfare

Principal Investigator

MIYASAKA Kyoko  Tokyo Metro Found Res Aging and Promotion of Human Welfare, Tokyo Metro Inst Gerontology, 東京都老人総合研究所, 研究副部長 (90166140)

Co-Investigator(Kenkyū-buntansha) OHTA Minoru  Tokyo Metro Found Res Aging and Promotion of Human Welfare, Tokyo Metro Inst Gerontology, Research Assistant, 東京都老人総合研究所, 助手 (70133634)
TAKIGUCHI Soichi  Kyushu Cancer Center, Dept of Clinical Research, Researcher, 臨床研究部, 研究員 (00280793)
Project Period (FY) 2003 – 2005
KeywordsSHIP2 / ALDH2 / gene polymorphism / pancreatic cancer / alcohol
Research Abstract

We found positive associations of gene polymorphisms and chole-pancreatic disorders. The CCK-A receptor (AR) gene polymorphism (-81A/G, -128G1T) was associated with panic disorder, alcoholism, and obesity. The adrenalin beta 3R mutation (Trp64Arg) was associated with higher BMI, and ALDH2 mutation (Glu to Lys) was the risk of pancreatic cancer in the smokers. The ghrelin receptor polymorphism (177T/C) was a risk of Bulimia Nervosa. The CEL gene polymorphism was associated with alcoholic pancreatitis. The SHIP2 gene polymorphism was associated with glucose intolerance. However, we could not found polymorphisms of PAR2, Klotho, Cyp2A6, and Ghrelin, which had been reported in the Western counties.
The gene expression of CCK-AR was decreased in the gallbladder with gallstones. However, it is still unknown whether there were positive associations of CCK-AR polymorphism and the levels of CCK-AR gene expression.
We observed new phenotypes of CCK-ARKO mice. CCK-ARKO mice showed over-eating after the restraint stress, and they drank alcohol more than other genotypes, possibly due to the higher expression of dopamine 2R protein in the nucleus accumbens. The frequency of gallstone formation was increased in CCK ARKO mice, compared with wild-type mice, however, the sex difference was not clarified, yet.

  • Research Products

    (60 results)

All 2005 2004 2003

All Journal Article (58 results) Book (2 results)

  • [Journal Article] Dose-dependency of life span prolongation of F344/DuCrj rats injected with (-)deprenyl2005

    • Author(s)
      Kitani K, Kanai S, Miyasaka K
    • Journal Title

      Biogerontology 6

      Pages: 1-6

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Stimualtory effect of ethanol on pancreatic secretion in conscious rats requires CCK-A receptor2005

    • Author(s)
      Miyasaka K, et al.
    • Journal Title

      Pancreas 30

      Pages: e22-e28

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cholecystokinin A receptor gene promoter polymorphism and intelligence2005

    • Author(s)
      Shimokata, H, Ando F, Niino N, Miyasaka
    • Journal Title

      Ann Epidem 15

      Pages: 196-201

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Inactive aldehyde dehydrogenase-2 increased the risk of pancreatic cancer among smokers in a Japanese male population2005

    • Author(s)
      Miyasaka K, et al.
    • Journal Title

      Pancreas 30

      Pages: 1-5

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Differences in ethanol ingestion between cholecystokinin-A receptor deficient and -B receptor deficient mice2005

    • Author(s)
      Miyasaka K, et al.
    • Journal Title

      Alcohol and Alcoholism 40

      Pages: 176-180

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Carboxylester lipase gene polymorphism as a risk of alcohol induced pancreatitis2005

    • Author(s)
      Miyasaka K
    • Journal Title

      Pancreas 30

      Pages: r87-e91

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Overeating after restraint stress in cholecystokinin-A receptor deficient mice2005

    • Author(s)
      Miyasaka K
    • Journal Title

      Jpn J Physiol 55

      Pages: 285-291

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Sp-family of transcription factors regulates the human SHIP2 gene expression2005

    • Author(s)
      Ishida S, et al., Miyasaka K, et al.
    • Journal Title

      Gene 348

      Pages: 135-141

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] L-アラビノース摂取による骨格筋線維組成の変化2005

    • Author(s)
      菊沢歩, 田中紀子, 市川みね子, 宮坂京子
    • Journal Title

      日本栄養・食糧学会誌 58

      Pages: 51-57

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 遺伝子異常と胆石2005

    • Author(s)
      船越顕博, 宮坂京子
    • Journal Title

      臨床消化器内科 20

      Pages: 41-48

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 膵癌と性差2005

    • Author(s)
      船越顕博, 澄井俊彦, 宮坂京子
    • Journal Title

      性差と医療 2

      Pages: 61-65

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 膵癌と性差2005

    • Author(s)
      宮坂京子
    • Journal Title

      Bio Clinica

      Pages: 36-40

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Dose-dependency of life span prolongation of F344/DuCrj rats injected with (-)deprenyl.2005

    • Author(s)
      Kitani K, Kanai S, Miyasaka K, Carrilo M-C, Ivy GO
    • Journal Title

      Biogerontology 6

      Pages: 1-6

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Stimualtory effect of ethanol on pancreatic secretion in conscious rats requires CCK-A receptor.2005

    • Author(s)
      Miyasaka K, Kanai S, Ohta M, Hosoya H.
    • Journal Title

      Pancreas 30

      Pages: e22-e28

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cholecystokinin A receptor gene promoter polymorphism and intelligence2005

    • Author(s)
      Shimokata, H, Ando F, Niino N, Miyasaka K, Funakoshi A.
    • Journal Title

      Ann Epidem 15

      Pages: 196-201

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Inactive aldehyde dehydrogenase-2 increased the risk of pancreatic cancer among smokers in a Japanese male population.2005

    • Author(s)
      Miyasaka K, Kawanami T, Shimokata H, Ohta S, Funakoshi A.
    • Journal Title

      Pancreas 30

      Pages: 1-5

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Differences in ethanol ingestion between cholecystokinin-A receptor deficient and -B receptor deficient mice.2005

    • Author(s)
      Miyasaka K, Hosoya H, Takano S, Ohta M, Sekime A, Kanai S, Matsui T, Funakoshi A.
    • Journal Title

      Alcohol and Alcoholism 40

      Pages: 176-180

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Sp-family of transcription factors regulates the human SHIP2 gene expression.2005

    • Author(s)
      Ishida S, Funakoshi A, Miyasaka K, Iguchi H, Takiguchi S.
    • Journal Title

      Gene 348

      Pages: 135-141

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Carboxylester lipase gene polymorphism as a risk of alcohol induced pancreatitis2005

    • Author(s)
      Miyasaka K, Ohta M, Takano S, Hayashi H, Higuchi S, Maruyama K, Tando Y, Nakamura T, Funakoshi A.
    • Journal Title

      Pancreas 30

      Pages: e87-e91

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A. Overeating after restraint stress in cholecystokinin-A receptor deficient mice2005

    • Author(s)
      Miyasaka K, Kanai S, Ohta M, Hosoya H, Takano S, Sekime A, Sakurai C, Kaneko T, Tahara S, Funakoshi
    • Journal Title

      Jpn J Physiol 55

      Pages: 285-291

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Association of cholecystokinin-A receptor gene polymorphism with alcohol dependence in a Japanese population2004

    • Author(s)
      Miyasaka K, et al.
    • Journal Title

      Alcohol and Alcoholism 39

      Pages: 25-28

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Association of Cholecystokinin-A Receptor Gene Polymorphisms and Panic Disorder in Japanese2004

    • Author(s)
      Miyasaka K, et al.
    • Journal Title

      Am J Med Genet 127B

      Pages: 78-80

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Histopathological difference between chronic pancreatitis amimal models and human chronic pancreatitis2004

    • Author(s)
      Suda H, Jimi A, Miyasaka K, Funakoshi A.
    • Journal Title

      Pancreas 28

      Pages: e86-e89

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Enhanced gastric emptying of a liquid gastric load in mice lacking cholecystokinin-B receptor : A study of CCK-A, B, and AB receptor gene knockout mice2004

    • Author(s)
      Miyasaka K, et al.
    • Journal Title

      J Gastroenterol 39

      Pages: 319-323

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Physiological and pathological age-associated changes in diurnal rhythm of energy expenditure in rats.2004

    • Author(s)
      Miyasaka K, et al.
    • Journal Title

      Arch Geriat Gerontol 39

      Pages: 83

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Absence of the cholecystokinin-A receptor deteriorates homeostasis of body temperature in response to changes in ambient temperature.2004

    • Author(s)
      Nomoto S, et al., Miyasaka K
    • Journal Title

      Am J Physiol 287

      Pages: R556-R561

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 強度条件の異なる身体運動負荷が血漿中消化管ホルモンの変動に及ぼす影響。2004

    • Author(s)
      永松俊哉, 荒尾孝, 宮坂京子
    • Journal Title

      体力研究 102

      Pages: 1-6

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 肥満、糖尿病を自然発症するOLETFラットにおけるL-アラビノースの長期投与の効果2004

    • Author(s)
      関目綾子, 太田稔, 船越顕博, 宮坂京子
    • Journal Title

      消化と吸収 26

      Pages: 21-25

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] CCK-A受容体ノックアウトマウスにおけるストレス負荷時の摂食量の変動2004

    • Author(s)
      太田稔, 関目綾子, 金井節子, 宮坂京子
    • Journal Title

      消化と吸収 27

      Pages: 22-25

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 老化に伴う摂食低下におけるorexin, CCKの関与について-老化動物での検討2004

    • Author(s)
      宮坂京子, 高野紗恵子, 船越顕博
    • Journal Title

      消化と吸収 27

      Pages: 48-50

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 飲酒、喫煙と膵癌発症リスク2004

    • Author(s)
      船越顕博, 川波賢子, 宮坂京子
    • Journal Title

      消化と吸収

      Pages: 163-165

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] にがうりエキス酢のエネルギー代謝回転亢進と基礎代謝上昇効果2004

    • Author(s)
      宮坂京子 他
    • Journal Title

      老年消化器病 16

      Pages: 95-99

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 胆石、胆嚢機能と遺伝子2004

    • Author(s)
      船越顕博, 宮坂京子
    • Journal Title

      内科 95

      Pages: 313-318

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 膵外分泌におけるnew concept2004

    • Author(s)
      宮坂京子
    • Journal Title

      胆と膵 25

      Pages: 804-805

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Role of 5-HT1B receptors in entrainment disorder of Otsuka Long Evans Tokushima Fatty (OLETF) rats.2004

    • Author(s)
      Shimazoe T, Nakamura S, Kobayashi K, Watanabe S, Miyasaka K, Kono A, Funakoshi A.
    • Journal Title

      Neuroscience 123

      Pages: 201-205

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Association of cholecystokinin-A receptor gene polymorphism with alcohol dependence in a Japanese population.2004

    • Author(s)
      Miyasaka K, Yoshida Y, Matsushita S, Higuchi S, Maruyama K, Niino N, Ando F, Shimokata H, Ohta S, Funakoshi A.
    • Journal Title

      Alcohol and Alcoholism 39

      Pages: 25-28

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Association of Cholecystokinin-A Receptor Gene Polymorphisms and Panic Disorder in Japanese2004

    • Author(s)
      Miyasaka K, Yoshida Y, Matsushita S, Higuchi S, Shirakawa O, Shimokata H, Funakoshi A.
    • Journal Title

      Am J Med Genet 127B

      Pages: 78-80

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Histopathological difference between chronic pancreatitis amimal models and human chronic pancreatitis.2004

    • Author(s)
      Suda H, Jimi A, Miyasaka K, Funakoshi A.
    • Journal Title

      Pancreas 28

      Pages: e86-e89

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Enhanced gastric emptying of a liquid gastric load in mice lacking cholecystokinin-B receptor: A study of CCK-A, B, and AB receptor gene knockout mice.2004

    • Author(s)
      Miyasaka K, Ohta M, Kanai S, Yoshida Y, Sato N, Nagata A, Matsui T, Noda T, Jimi A, Takiguchi S, Takata Y, Kawanami T, Funakoshi A.
    • Journal Title

      J Gastroenterol 39

      Pages: 319-323

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Physiological and pathological age-associated changes in diurnal rhythm of energy expenditure in rats.2004

    • Author(s)
      Miyasaka K, Ichikawa M, Momose K, Araki A, Kobayashi M, Ichimaru Y, Funakoshi A.
    • Journal Title

      Arch Geriat Gerontol 39

      Pages: 83-91

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Absence of the cholecystokinin-A receptor deteriorates homeostasis of body temperature in response to changes in ambient temperature.2004

    • Author(s)
      Nomoto S, Ohta M, Kanai S, Yoshida Y, Takiguchi S, Funakoshi A, Miyasaka K.
    • Journal Title

      Am J Physiol: Regul Integrative 287

      Pages: R556-R561

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Association of cholecystokinin 1 receptor and beta3-adrenergic receptor polymorphisms with midlife weight gain.2004

    • Author(s)
      Koda M, Ando F, Niino N, Shimokata H, Miyasaka K, Funakoshi A.
    • Journal Title

      Obes Res 8

      Pages: 1212-1216

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Orexin-A does not stimulated food intake in old rats.2004

    • Author(s)
      Takano S, Kanai S, Hosoya H, Ohta M, Uematsu H, Miyasaka K.
    • Journal Title

      Am J Physiol; Gastrointestinal Physiol 287

      Pages: G1182-G1187

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Physical activity prevented age-related decline in energy metabolism in genetically obese and diabetic rats, but not in control rats2003

    • Author(s)
      Miyasaka K, et al.
    • Journal Title

      Mech Aging and Develop 124

      Pages: 183-190

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Lack of cholecystokinin (CCK)-A receptor enhanced gallstone formation : A study in CCK-A receptor gene knockout mice2003

    • Author(s)
      Sato N, Miyasaka K, et al.
    • Journal Title

      Dig Dis Sci 48

      Pages: 1944-1947

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Bitter melon-malt venegar increases daily energy turnover in rats.2003

    • Author(s)
      Ichikawa M, et al., Miyasaka K
    • Journal Title

      J Nutr Sci Vitaminol 49

      Pages: 428-433

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Central administration of ghrelin stimulates pancreatic exocrine secretion via the vagus in conscious rats2003

    • Author(s)
      Sato N, et al., Miyasaka K
    • Journal Title

      Jpn J Phsyiol 53

      Pages: 443-449

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cholecystokinin and cholecystokinin receptors. A review article.2003

    • Author(s)
      Miyasaka K, Funakoshi A
    • Journal Title

      J Gastroenterol 38

      Pages: 1-13

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] コレシストキニン-A,B,AB受容体遺伝子ノックアウトマウスのエネルギー代謝2003

    • Author(s)
      宮坂京子 他
    • Journal Title

      消化と吸収 25

      Pages: 21-24

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 沖縄特産にがうりエキス酢のエネルギー代謝回転亢進と基礎代謝上昇効果2003

    • Author(s)
      宮坂京子 他
    • Journal Title

      消化と吸収 26

      Pages: 103-108

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 胆石とコーヒー、緑茶2003

    • Author(s)
      船越顕博, 宮坂京子
    • Journal Title

      肝胆膵 46

      Pages: 139-145

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 肥満症2003

    • Author(s)
      船越顕博, 内村浩太郎, 宮坂京子
    • Journal Title

      日本臨床 61

      Pages: 479-484

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] コレシストキニン受容体の胃排出速度に及ぼす影響2003

    • Author(s)
      佐藤紀一, 船越顕博, 宮坂京子
    • Journal Title

      消化器科 37

      Pages: 225-229

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Physical activity prevented age-related decline in energy metabolism in genetically obese and diabetic rats, but not in control rats.2003

    • Author(s)
      Miyasaka K, Ichikawa M, Kawanami T, Kanai S, Ohta M, Sato N, Ebisawa H, Funakoshi A.
    • Journal Title

      Mech Aging and Develop 124

      Pages: 183-190

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Lack of cholecystokinin (CCK)-A receptor enhanced gallstone formation: A study in CCK-A receptor gene knockout mice.2003

    • Author(s)
      Sato N, Miyasaka K, Suzuki S, Kanai S, Ohta M, Kawanami T, Yoshida Y, Takiguchi S, Noda T, Takata Y, Funakoshi A.
    • Journal Title

      Dig Dis Sci 48

      Pages: 1944-1947

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Bitter melon-malt venegar increases daily energy turnover in rats.2003

    • Author(s)
      Ichikawa M, Ohta M, Kanai S, Yoshida Y, Takano S, Ueoka T, Takahashi T, Kimoto K, Funakoshi A, Miyasaka K.
    • Journal Title

      J Nutr Sci Vitaminol 49

      Pages: 428-433

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Central administration of ghrelin stimulates pancreatic exocrine secretion via the vagus in conscious rats.2003

    • Author(s)
      Sato N, Kanai S, Takano S, Kurosawa M, Funakoshi A, Miyasaka K.
    • Journal Title

      Jpn J Phsyiol 53

      Pages: 443-449

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cholecystokinin and cholecystokinin receptors. A review article.2003

    • Author(s)
      Miyasaka K, Funakoshi A.
    • Journal Title

      J Gastroenterol 38

      Pages: 1-13

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 専門医のための消化器病学2005

    • Author(s)
      宮坂京子
    • Total Pages
      637
    • Publisher
      医学書院
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 臨床研修イラストライテッド消化器系マニュアル2005

    • Author(s)
      宮坂京子
    • Total Pages
      219
    • Publisher
      羊土社
    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 2007-12-13  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi