2005 Fiscal Year Final Research Report Summary
Identification and regulation of factors related to progression of renal
| Project/Area Number |
15390268
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Niigata University |
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Principal Investigator |
SHIMIZU Fujio Niigata University, Institute of Medicine and Dentistry, Professor, 医歯学系, 教授 (40012728)
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| Co-Investigator(Kenkyū-buntansha) |
KAWACHI Hiroshi Niigata University, Institute of Medicine and Dentistry, Associate Professor, 医歯学系, 助教授 (60242400)
ORIKASA Michiaki Niigata University, Institute of Medicine and Dentistry, Professor, 医歯学系, 教授 (30185681)
NARITA Ichiei Niigata University, Institute of Medicine and Dentistry, Associate Professor, 医歯学系, 助教授 (20272817)
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| Project Period (FY) |
2003 – 2005
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| Keywords | mesangioproliferative glomerulonephritis / Thy-1 nephritis / irreversible glomerulonephritis / anti-Thy-1monoclonal antibody 1-22-3 / podocyte / fractalkine / FK506 / FTY720 |
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| Research Abstract |
Summarized main results are : (1)A new irreversible model for progressive renal lesions has been established in rats by injecting simultaneously the anti-slit diaphragm monoclonal antibody (5-1-6) and anti-Thy-1 monoclonal antibody (1-22-3), based on our previous finding that podocyte injury could change the reversible injury derived from the mesangial injury to the irreversible one. (2)The increased intraglomerular expression of fractalkine and the increased intraglomerular infiltration of CX3CR1(receptor to fractalkine)-positive cells were intimately related to the progression of the renal lesions. (3)Antibodies against CD4-positive cells or Th1 cytokines or FK506 (blocker of Th1 cytokines as well as FTY720,MMF, spironolactone and ACE inhibitors suppressed the progression of renal lesions. (4)The decrease in the collagenase activity was a good marker for the increase of mesangial matrix. (5)The suppression of the expression of TGF-beta at mRNA level resulted in the suppression of the increase of mesangial matrix. (6)Traditional Chinese medicine, GTW could suppress the amount of urinary protein, mesangial matrix increase and the expression of MCP-2 and IL-2 expression in Thy-1 nephritis. (7)The eartly intervention with low protein diet could delay the progression of renal diseases.
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Research Products
(83 results)
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[Journal Article] Role of p38 mitogen-activated protein kinase activation in podocyte injury and proteinuria in experimental nephrotic syndrome.2005
Author(s)
Koshikawa M, Mukoyama M, Mori K, Suganami T, Sawai K, Yoshioka T, Nagae T, Yokoi H, Kawachi H, Shimizu F, Sugawara A, Nakao K.
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Journal Title
Journal of the American Society of Nephrology. 16
Pages: 2690-2701
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Continuous, noninvasive monitoring of local microscopic inflammation using a genetically engineered cell-based biosensor.2005
Author(s)
Meng Y, Kasai A, Hiramatsu N, Hayakawa K, Yamauchi K, Takeda M, Kawachi H, Shimizu F, Yao J, Kitamura M
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Journal Title
Laboratory Investigation 85
Pages: 1429-1439
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Novel expression of sodium/myo-inositol co-transporter in pdoocytes in puromycin aminonucleoside nephrosis.2004
Author(s)
Watanabe Y, Kobayashi T, Yaoita E, Kawachi H, Yamauchi a, Inoue T, Shimizu F, Yoshida Y, EI-Shemi AG, Okada H, Suzuki H, Yamamoto T.
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Journal Title
Nephrology Dialysis Transplantation 19
Pages: 817-822
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Role of megalin in endocytosis of advanced glycation end products : Implications for a novel protein binding to both megalin and advanced glycation end products2003
Author(s)
Saito A, Nagai R, Tanuma A, Hama H, Cho K, Takeda T, Yoshida Y, Toda T, Shimizu F, Horiuchi S, Gejyo F.
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Journal Title
Journal of the American Society of Nephrology 14
Pages: 1123-1131
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Bioengineered implantation of megalin-expressing cells : A potential intracorporeal therapeutic model for uremic toxin protein clearance in renal failure.2003
Author(s)
Saito A, Kazama J.J, Iino N, Cho K, Sato N, Yamazaki H, Oyama Y, Takeda T, Orlando R.A, Narita I, Goto s, Saito N, Song J, Kondo D, Omori K, Shimizu F, Tabata Y, Gejyo F
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Journal Title
Journal of the American Society of Nephrology Laboratory Investigation 14
Pages: 2025-2032
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Genetic polymorphism of NPHS1 modifies the clinical manifestations of IgA nephropathy.2003
Author(s)
Narita I, Goto s, Saito N, Song J, Kondo D, Omori K, Kawachi H, Shimizu F, Sakatsume M, Ueno M, Gejyo F.
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Journal Title
Laboratory Investigation 83
Pages: 1193-1200
Description
「研究成果報告書概要(欧文)」より
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