• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2005 Fiscal Year Final Research Report Summary

Neuroendocrinological study of prolactin releasing peptide

Research Project

Project/Area Number 15390292
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionSaitama University

Principal Investigator

INOUE Kinji  Saitama University, Faculty of Science, Professor, 理学部, 教授 (50091963)

Co-Investigator(Kenkyū-buntansha) SAKAI Takafumi  Saitama University, Faculty of Science, Professor, 理学部, 教授 (40235114)
Project Period (FY) 2003 – 2005
KeywordsProlactin-releasing peptide / stress / estrogen / solitary nucleus / adrenal gland / pituitary / ACTH / CRH
Research Abstract

Prolactin-releasing peptide(PrRP) was found as an endogenous ligand of an orphan G-protein coupled receptor(hGR3 for human and GPR10 for rat) in 1998. The PrRP is known to stimulate prolactin secretion and release in vitro and in vivo which suggest PrRP is a candidate of a prolactin-releasing hypophysiotropic factor. However, our morphological studies showed that PrRP-producing cell bodies were manily localized in the nucleus tractus solitary of medulla oblongata. Our previous study showed that PrRP is not classical hypophysiotropic factor but it stimulates ACTH secretion through CRH secretion and act as stress mediator in the central nermous system. In this study we demonstrated that PrRP produced in the adrenaline cells in the adrenal gland. In addition PrRP producing cells appeared in the area postrema of adrenalectomized rats. On the other hand, regulation of PrRP producing cells have not been well studied, we therefore examined the function of PrRP positive cells in the SON after nicotine treatment and found nicotine stimulates PrRP cells and non-PrRP cells in the SON. In addition we examined stress response of PrRP cells with or without estrogen treatment. In this study we found estrogen suppress stress response of PrRP cells.

  • Research Products

    (26 results)

All 2005 2004 2003

All Journal Article (26 results)

  • [Journal Article] Involvement of Central Metastin in the Regulation of Preovulatory LH Surge and Estrous Cyclicity in Female Rats.2005

    • Author(s)
      Kinoshita M. et al.
    • Journal Title

      Endocrinology 146

      Pages: 4431-6

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Estrogen suppresses the stress response of prolactin-releasing peptide-producing cells.2005

    • Author(s)
      Adachi S.et al..
    • Journal Title

      Neurosci Lett. 380

      Pages: 311-5

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Multistep differentiation of growth hormone-producing cells from their immature cells.2005

    • Author(s)
      Mogi C.et al.
    • Journal Title

      J Endocrinol. 184

      Pages: 41-50

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Nicotine stimulates prolactin-releasing peptide (PrRP) cells and non-PrRP cells in the solitary nucleus.2005

    • Author(s)
      Sun B.et al.
    • Journal Title

      Regul Pept. 126

      Pages: 91-6

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Identification of the Prolactin-Releasing Peptide-Producing Cell in the Rat Adrenal.2005

    • Author(s)
      Fujiwara K. et al.
    • Journal Title

      Gland. Regul Pept. 126

      Pages: 97-102

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Physiological role of prolactin-releasing peptide.2005

    • Author(s)
      Sun B.et al.
    • Journal Title

      Regul Pept. 126

      Pages: 27-33

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Involvement of Central Metastin in the Regulation of Preovulatory LH Surge and Estrous Cyclicity in Female Rats.2005

    • Author(s)
      Kinoshita M, Tsukamura H, Adachi S, Matsui H, Uenoyama Y, Iwata K, Yamada S, Inoue K, Ohtaki T, Matsumoto H, Maeda KI
    • Journal Title

      Endocrinology 146

      Pages: 4431-4436

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Estrogen suppresses the stress response of prolactin-releasing peptide-producing cells.2005

    • Author(s)
      Adachi S, Mochiduki A, Nemoto H, Sun B, Fujiwara K, Matsumoto H, Inoue K
    • Journal Title

      Neurosci Lett. 380

      Pages: 311-315

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Multistep differentiation of growth hormone-producing cells from their immature cells.2005

    • Author(s)
      Mogi C, Goda H, Mogi K, Takaki A, Yokoyama K, Tomida M, Inoue K
    • Journal Title

      J Endocrinol. 184

      Pages: 41-50

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Nicotine stimulates prolactin-releasing peptide (PrRP) cells and non-PrRP cells in the solitary nucleus.2005

    • Author(s)
      Sun B, Nemoto H, Fujiwara K, Adachi S, Inoue K
    • Journal Title

      Regul Pept. 126

      Pages: 91-96

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Identification of the Prolactin-Releasing Peptide-Producing Cell in the Rat Adrenal.2005

    • Author(s)
      Fujiwara K, Matsumoto H, Yada T, Inoue K
    • Journal Title

      Gland.Regul Pept. 126

      Pages: 97-102

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Physiological role of prolactin-releasing peptide.2005

    • Author(s)
      Sun B, Fujiwara K, Adachi S, Inoue K
    • Journal Title

      Regul Pept. 126

      Pages: 27-33

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Localization of ghrelin-producing cells in the stomach of the rainbow trout (Oncorhynchus mykiss).2004

    • Author(s)
      Sakata I., et al.
    • Journal Title

      Zoolog Sci. 21

      Pages: 757-62

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Ghrelin-induced growth hormone release from isolated rat anterior pituitary cells depends on intracellular and extracellular ca sources.2004

    • Author(s)
      Yamazaki M. et al.
    • Journal Title

      J Neuroendocrinol. 16

      Pages: 825-31

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Estrogen modulates ghrelin expression in the female rat stomach.2004

    • Author(s)
      Matsubara M. et al.
    • Journal Title

      Peptides 25

      Pages: 289-97

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Differentiation of skeletal muscle from pituitary folliculo-stellate cells and endocrine progenitor cells.2004

    • Author(s)
      Mogi C.et al.
    • Journal Title

      Exp Cell Res. 292

      Pages: 288-94

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Localization of ghrelin-producing cells in the stomach of the rainbow trout (Oncorhynchus mykiss)2004

    • Author(s)
      Sakata I, Mori T, Kaiya H, Yamazaki M, Kangawa K, Inoue K, Sakai T
    • Journal Title

      Zoolog Sci. 21

      Pages: 757-762

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Ghrelin-induced growth hormone release from isolated rat anterior pituitary cells depends on intracellular and extracellular ca sources2004

    • Author(s)
      Yamazaki M, Kobayashi H, Tanaka T, Kangawa K, Inoue K, Sakai T
    • Journal Title

      J Neuroendocrinol. 16

      Pages: 825-831

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Estrogen modulates ghrelin expression in the female rat stomach2004

    • Author(s)
      Matsubara M, Sakata I, Wada R, Yamazaki M, Inoue K, Sakai T
    • Journal Title

      Peptides. 25

      Pages: 289-297

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Differentiation of skeletal muscle from pituitary folliculo-stellate cells and endocrine progenitor cells2004

    • Author(s)
      Mogi C, Miyai S, Nishimura Y, Fukuro H, Yokoyama K, Takaki A, Inoue K
    • Journal Title

      Exp Cell Res. 292

      Pages: 288-294

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Change in Expression of Basic Fibroblast Growth Factor mRNA in a Pituitary Tumor Clonal Cell Line.2003

    • Author(s)
      Fukuro H. et al.
    • Journal Title

      Endoc. Pathol 14

      Pages: 145-9

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Grwth hormone secretagogue receptor expression in the cells of the stomach-projected afferent nerve in the rat nodose ganglion.2003

    • Author(s)
      Sakata I. et al.
    • Journal Title

      Neuroscience Letters 342

      Pages: 183-6

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Appearance of prolactin-releasing peptide (PrRP)-producing neurons in the area postrema of adrenalectomized rats.2003

    • Author(s)
      Fujiwara K. et al.
    • Journal Title

      Neuroscience Letters 338

      Pages: 127-30

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Change in Expression of Basic Fibroblast Growth Factor mRNA in a Pituitary Tumor Clonal Cell Line2003

    • Author(s)
      Fukuro H, Mogi C, Yokoyama K, Inoue K
    • Journal Title

      Endoc.Pathol 14

      Pages: 145-149

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Growth hormone secretagogue receptor expression in the cells of the stomach- projected afferent nerve in the rat nodose ganglion.2003

    • Author(s)
      Sakata I, Yamazaki M, Inoue K, Hayashi Y, Kangawa K, Sakai T
    • Journal Title

      Neuroscience Letters 342

      Pages: 183-186

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Appearance of prolactin-releasing peptide (PrRP)-producing neurons in the area postrema of adrenalectomized rats.2003

    • Author(s)
      Fujiwara K, Maruyama M, Usui K, Sakai T, Matsumoto H, Hinuma S, Kitada C, Inoue K
    • Journal Title

      Neuroscience Letters 338

      Pages: 127-130

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2007-12-13  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi