2006 Fiscal Year Final Research Report Summary
Morphological and functional neuroimaging studies on progressive changes in schizophrenia.
| Project/Area Number |
15390348
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nippon Medical School |
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Principal Investigator |
OKUBO Yoshiro Nippon Medical School, Graduate School of Medicine, Professor, 大学院・医学研究科, 教授 (20213663)
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| Co-Investigator(Kenkyū-buntansha) |
SUHARA Tetsuya National Institute of Radiological Sciences, Molecular Imaging Center, Group Leader, 分子イメージング研究センター・分子神経イメージング研究グループ, グループリーダー (90216490)
SUZUKI Hidenori Nippon Medical School, Graduate School of Medicine, Professor, 大学院・医学研究科, 教授 (30221328)
KAWARA Tokuhiro Tokyo Medical and Dental University, Depatment of Bioinfomatics, Research Associate, 大学院・保健衛生学研究科, 助手 (50234141)
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| Project Period (FY) |
2003 – 2006
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| Keywords | schizophrenia / PET / MRI・VBM / fMRI / Neurotropic factors / Peripheral benzodiazepine receptor |
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| Research Abstract |
Using both morphological and functional neuroimaging techniques, we aimed to elucidate the progressive changes in the brain of patients with schizophrenia. One hundred twenty patients with schizophrenia aged 20 to 49 years, 60 males and 60 females, and 120 age and gender matched healthy controls were examined by magnetic resonance imaging(MRI). Voxel-based morphometry revealed that age-related decline in the brain morphology was larger in the patient group than in the control groups. This indicates the existence of progressive neuropathology in schizophrenia. Further, the difference in the brain morphology between the patient group and the control group were more prominent in male than in female. Thus, future research should take gender difference into account. Positron emission tomography with [11C[DAA1106 makes it possible to evaluate peripheral benzodiazepine receptors which reflect activated microglia and gliosis in the living human brain. We conducted [11C[DAA1106 PET study in a preliminary sample of patients with schizophrenia and controls. However, there was no statistical difference between groups.
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[Journal Article] The antipsychotic sultopride is overdosed-A PET study of drug-induced receptor occupancy in comparison with sulpiride.2005
Author(s)
Takano, A.Suhara, T.Yasuno, F.Suzuki, K.Takahashi, H.Morimoto, T.Lee, Y.-J.Kusuhara, H.Sugiyama, Y.Okubo, Y.
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Journal Title
International Journal of Neuropsychopharmacology 9
Pages: 539-545
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] [11C]PE21 : a highly selective radioligand for PET examination of the dopamine transporter in monkey and human brain.2003
Author(s)
Halldin C, Erixon-Lindroth N, Pauli S, Chou YH, Okubo Y, karlsson P, Lundkvist C, Olsson H, Guilloteau D, Emond P, Farde L
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Journal Title
Eur J Nucl Med Mol Imaging 30
Pages: 1220-1230
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] No association between genotype of the promotor region of serotonin transporter gene and serotonin transporter binding in human brain measured by PET.2003
Author(s)
Shioe K., Ichimiya T, Suhara T., Takano A., Sudo Y., Yasuno F., Hirano M., Shinohara M., Kagami M., Okubo Y., Nankai M., Kanba S
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Journal Title
Synapse 48
Pages: 184-188
Description
「研究成果報告書概要(欧文)」より
