2004 Fiscal Year Final Research Report Summary
Neurodegenerative mechanism on ribotoxic stress and apoptosis
| Project/Area Number |
15390351
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Osaka University |
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Principal Investigator |
TAKEDA Masatoshi Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (00179649)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Toshihisa Osaka University, Graduate School of Medicine, Lecturer, 医学系研究科, 講師 (10294068)
KUDO Takashi Osaka University, Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (10273632)
KAMINO Kouzin Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (40307955)
OKOCHI Masayasu Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (90335357)
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| Project Period (FY) |
2003 – 2004
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| Keywords | Alzheimer Disease / Tau Protein / Apoptosis / Ribosome / Microtubule |
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| Research Abstract |
Neurofibrillary tangles(NFTs) are neuropathological hallmarks of Alzheimer disease(AD) and abnormally hyperphosphorylated tau is the major protein component of NFTs. According to our previous studies on the regulation of phosphorylation of tau protein, an involvement of intrinsic anti-apoptotic factor in neurodegenerative process in AD, is speculated. XIAP(X chromosome-linked inhibitor of apoptosis), one of intrinsic anti-apoptotic proteins, was investigated in this study. First, higher expression of XIAP was observed in AD brain than in control brain. Second, the binding of XIAP with N-terminal tau sequence was observed only when the first methionine was deleted. These results suggest that XIAP might be involved in neurodegenerative process of AD or tauopathy, that is slowly progressive.
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