2004 Fiscal Year Final Research Report Summary
Establishment of cDNA array-based predictive diagnostics of cancer for personalized medicine
| Project/Area Number |
15390368
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
TADA Mitsuhiro Hokkaido Univ., Inst.Genet.Med., Asso.Prof., 遺伝子病制御研究所, 助教授 (10241316)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Satoshi Hokkaido Univ., Grad.Sch.Med., Prof., 大学院・医学研究科, 教授 (30215454)
MORIUCHI Tetsuya Hokkaido Univ., Inst.Genet.Med., Prof., 遺伝子病制御研究所, 教授 (20174394)
HAMADA Jun-ichi Hokkaido Univ., Inst.Genet.Med., Asso.Prof., 遺伝子病制御研究所, 助教授 (50192703)
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| Project Period (FY) |
2003 – 2004
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| Keywords | cDNA array data / expression profile / human cancer / malignant character / personalized medicine |
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| Research Abstract |
This project aimed to establish a predictive method of cDNA array-based prediction of malignant characters of cancers for personalized treatment for patients. We collected frozen cancer tissue samples surgically reseated in 31 hospitals in Hokkaido prefecture and analyzed the mRNA expression profiles with cDNA array analysis. By using of a novel computer algorithm which efficiently select features (gene expressions) that were significantly correlated with malignant characters of cancers, we explored functional significance of the gene expressions and established an effective method of personalization.
1)We could collect more than 5,800 cases of cancer samples and the pertinent clinicopathological data.
2)Among them, 600 cases were analyzed with cDNA array.
3)We developed a new method of feature subset selection utilizing k-nearest neighbor as an assessment function, a method of ensemble machine learning combining probabilistic neural networks.
4)By applying this method, we could effectively predict lymph node metastasis of colorectal cancers, lung cancers and esophageal cancers, short term survival of patients with pancreatic cancers, long-term survival of gastric caner patients, and perineural invasion of bile-duct cancers, histological malignancy of breast cancers and liver cancers. These have been reported in academic meetings and published in international journals.
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Research Products
(17 results)
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[Journal Article] Right and left-sided colorectal cancers display distinct expression profiles and the anatomical stratification allows a high accuracy prediction of lymph node metastasis.2005
Author(s)
Komuro K, Tada M, Tamoto E, Kawakami A, Matsunaga A, Teramoto K, Shindoh G, Takada M, Murakawa K, Kanai M, Kobayashi N, Fujiwara Y, Nishimura N, Hamada J-I, Ishizu A, Ikeda H, Kondo S, Katoh H, Moriuchi T, Yoshiki T
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Journal Title
J Surg Res 124
Pages: 216-224
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Prediction of lymphatic invasion/lymph node metastasis, recurrence, and survival in patients with gastric cancer by cDNA array-based expression profiting.2005
Author(s)
Teramoto K, Tada M, Tamoto E, Abe M, Kawakami A, Komuro K, Matsunaga A, Shindoh G, Takada M, Murakawa K, Kanai M, Kobayashi N, Fujiwara Y, Nishimura N, Shirata K, Takahishi T, Ishizu A, Ikeda H, Hamada J-I, Kondo S, Katoh H, Moriuchi T, Yoshiki T
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Journal Title
J Surg Res 124
Pages: 225-236
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Aberrant expression of HOX genes in human invasive breast carcinoma.2005
Author(s)
Makiyama K, Hamada J, Takada M, Murakawa K, Takahashi Y, Tada M, Tamoto E, Shindo G, Matsunaga A, Teramoto K, Komuro K, Kondo S, Katoh H, Koike T, Moriuchi T
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Journal Title
Oncol Rep 13
Pages: 673-679
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] p53-defective tumors with a functional apoptosome-mediated pathway : a new therapeutic target.2005
Author(s)
Mashima T, Oh-hara T, Sato S, Mochizuki M, Sugimoto Y, Yamazaki K, Hamada J, Tada M, Moriuchi T, Ishikawa Y, Kato Y, Tomoda H, Yamori T, Tsuruo T
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Journal Title
J Natl Cancer Inst 18
Pages: 765-777
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Expression profiles of 39 HOX genes in normal human adult organs and anaplastic thyroid cancer cell lines by quantitative real-time RT-PCR system.2004
Author(s)
Takahashi Y, Hamada J-I, Murakawa K, Takada M, Tada M, Nogami I, Hayashi N, Nakamori S, Monden M, Miyamoto M, Katoh H, Moriuchi T
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Journal Title
Exp Cell Res 293
Pages: 144-153
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Gene-expression profile changes correlated with tumor progression and lymph node metastasis in esophageal cancer.2004
Author(s)
Tamoto E, Tada M, Murakawa K, Takada M, Shindo G, Teramoto K-I, Matsunaga A, Komuro K, Kanai M, Kawakami A, Fujiwara Y, Kobayashi N, Shirata K, Nishimura N, Okushiba S, Kondo S, Hamada J-I, Yoshiki T, Moriuchi T, Katoh H
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Journal Title
Clin Cancer Res 10
Pages: 3629-3638
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Prediction of lymph node metastasis and perineural invasion of biliary tract cancer by selected features from cDNA array data.2004
Author(s)
Murakawa K, Tada M, Takada M, Tamoto E, Shindoh Gs Teramoto K-I, Matsunaga A, Komuro K, Kanai M, Kawakami A, Fujiwara Y, Kobayashi N, Shirata K, Nishimura N, Okushiba S-I, Kondo S, Hamada J-I, Katoh H, Yoshiki T, Moriuchi T
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Journal Title
J Surg Res 122
Pages: 184-194
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Prediction of Lymph Node Metastasis by Analysis of Gene Expression Profiles in Non-small Cell Lung Cancer.2004
Author(s)
Takada, M, Tada M, Tamoto E, Kawakami A, Murakawa K, Shindoh G, Teramoto K-I, Matsunaga A, Komuro K, Kanai M, Fujiwara Y, Shirata K, Nishimura N, Miyamoto M, Okushiba S-I, Kondo S, Hamada J-I, Katoh H, Yoshiki T, Moriuchi T
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Journal Title
J Surg Res 122
Pages: 61-69
Description
「研究成果報告書概要(欧文)」より
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