2006 Fiscal Year Final Research Report Summary
Regenerative Medicine of the Jawbone Using Mesechymal Stem Cells and /or Bioactive Factors
| Project/Area Number |
15390624
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
KINOSHITA Yukihiko Kanagawa Dental College, Frontier Oral Science, Professor, 高次口腔科学研究所, 教授 (70084770)
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| Co-Investigator(Kenkyū-buntansha) |
TABATA Yasuhiko Kyoto University, Frontier Medical Science, Professor, 再生医科学研究所, 教授 (50211371)
IKADA Yoshito Nara Medical University, School of Medicine, Professor, 医学部教授, 教授 (00025909)
KAWASE Toshio Kanagawa Dental College, School of Dentistry, Professor, 歯学部, 教授 (30084784)
OZONO Satoru Kanagawa Dental College, Frontier Oral Science, Associate Professor, 高次口腔科学研究所, 助教授 (40084785)
TODOKI Kazuo Kanagawa Dental College, School of Dentistry, Lecturer, 歯学部, 講師 (90139577)
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| Project Period (FY) |
2003 – 2006
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| Keywords | Poly(LA-CL) / statin / 17-estradiol / bFGF / PRP / PGA / regenerative medicine / jawbone |
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| Research Abstract |
1. The effects of combining a porous poly(L-lactide-co-e-caprolactone)/β-TCP membrane with a bFGF incorporating gelatin sponge on bone regeneration in mandibular ridges of beagles was evaluated. The results suggested that this technique will be applicable for alveolar ridge reconstruction.
2. Compactin and Pitavastatin increased activity of alkaline phosphatase of MC3T3-E1 cells (osteoblast-like cells) and enhanced these calcification. Therefore, Pitavastatin evoked apotosis of Raw cells ( macrophage-like cells) and inhibited differentiation to osteoclasts.
Combination of bFGF and 17β-estradiol to the osteogenic medium promoted differentiation of MC3T3-E1 cells without decrease of cell proliferation.
3. β-estoradiol incorporated PLGA and hPTH incorporated PLGA showed tendency to increase alveolar ridge post extraction. BMP-2 incorporated gelatin containing β-TCP showed remarkable bone regeneration in defects of the calvaria and the mandibular ramus.
4.Combination of PRP or bFGF incorporated gelatin with particulate cancellous bone and marrow showed tendency to promote bone regeneration in the mandibular marginal resection of beagles. However, there is no significant difference between those and control. An additional experiment is needed.
5.Complex of rat bone marrow stromal cells and hydroxyapatite coated PGA/collagen sponge showed more bone formation in the subcutaneous implants than control.
6. bFGF incorporated gelatin was applied to 11 patients with periodontal disease or atrophy of the alveolar ridge for dental implant. The results showed no harmful events and good outcome.
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[Journal Article] Medical Do. Co2007
Author(s)
Kinoshita Y
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Journal Title
New development of drag delivery system and the clinical appliance ed.Tabata Y
Pages: 3
Description
「研究成果報告書概要(欧文)」より
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