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2005 Fiscal Year Final Research Report Summary

Study on actual status of adult rotavirus infections in Southern Asia and Southeastern Asia

Research Project

Project/Area Number 15406028
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Hygiene
Research InstitutionSapporo Medical University

Principal Investigator

KOBAYASHI Nobumichi  Sapporo Medical University, School of Medicine, professor, 医学部, 教授 (80186759)

Co-Investigator(Kenkyū-buntansha) KOJIMA Kazunobu  Sapporo Medical University, School of Medicine, assistant professor, 医学部, 講師 (20264517)
ISHINO Masaho  Sapporo Medical University, School of Medicine, associate professor, 医学部, 助教授 (30232325)
TANIGUCHI Koki  Fujita Health University, School of Medicine, professor, 医学部, 教授 (40094213)
MISE Keiji  Sapporo Medical University, School of Medicine, instructor, 医学部, 助手 (30200025)
SUMI Ayako  Sapporo Medical University, School of Medicine, assistant professor, 医学部, 講師 (10363699)
Project Period (FY) 2003 – 2005
Keywordsrotavirus / diarrhea / adult / Southern Asia / Southeast Asia / typing / gene / sequence
Research Abstract

The purpose of this study is to characterize rotaviruses which cause diarrheal diseases in adults in Southern Asian and Southeast Asian regions. This study was performed in collaboration with India, Bangladesh, Thailand, and China. Stool specimens were collected from diarrheal patients in a period between 2003 and 2005. While detection rate of group A rotavirus in children was 25-35%, detection rate in adult ranged from approx. 1% to 10%. In the study in China, most rotavirus strains from children and adults showed identical antigenic types. Group B rotavirus was detected in adult stool specimens in Bangladesh (14 specimens) and China (2 specimens). In India, group B rotavirus was detected by RT-PCR in about 20% of diarrheal stool specimens from children. Phylogenetic analysis of the group B rotaviruses from individual countries indicated that the viruses from India and Bangladesh were genetically closely related but distinct from Chinese viruses. The Indian-Bangladeshi group B rotavir … More uses and Chinese viruses were suggested to be diverged from a common ancestral virus approximately 60-70 years ago based on estimation of mutation rate calculated for Chinese virus strains. In Bangladesh, an unusual rotavirus strain was detected. This virus was genetically different from the known group A, B, and C rotaviruses, and suggested to represent a novel species (group) of rotavirus. As a study on special characteristic of group B rotavirus, i.e., causing diarrhea primarily in adults, nonstructural protein NSP4 was studied for its sequence diversity and presence of enterotoxin activity which is known as one of the mechanisms causing diarrhea in animals. As a result, group B rotavirus NSP4 exhibited high degree of sequence divergence from group A rotavirus NSP4, however, it was demonstrated that sequences near the C-terminal region possess enterotoxin activity in suckling mice. These findings suggested that group B rotavirus may have similar mechanisms for causing diarrhea in human to group A rotavirus. Less

  • Research Products

    (14 results)

All 2006 2005 2004 2003

All Journal Article (12 results) Book (2 results)

  • [Journal Article] Comparison of NSP4 protein between group A and B human rotaviruses : detection of novel diarrhea-causing sequence in group B NSP4.2006

    • Author(s)
      Ishino M, Mise K, et al.
    • Journal Title

      Archives of Virology 151

      Pages: 173-182

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] An outbreak of rotavirus infection among adults in an institution for rehabilitation : long-term residence in a closed community as a risk factor for rotavirus illness.2006

    • Author(s)
      Iijima Y, iwamoto T, et al.
    • Journal Title

      Scadinavian Journal of Infectious Disease (in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Molecular characterization of a porcine Group A rotavirus strain with G12 genotype specificity.2006

    • Author(s)
      Ghosh S, Varghese V, et al.
    • Journal Title

      Archives of Virology (in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] RT-PCR based diagnosis revealed importance of human group B rotavirus infection in childhood diarrhea.2006

    • Author(s)
      Barman P, Ghosh S, et al.
    • Journal Title

      Journal of Clinical Virology (in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Comparison of NSP4 protein between group A and B human rotaviruses : detection of novel diarrhea-causing sequence in group B NSP4.2006

    • Author(s)
      Ishino M, Mise K, Takemura H, Ahmed MU, Alam MM, Naik TN, Kobayashi N.
    • Journal Title

      Archives of Virology 151

      Pages: 173-182

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] An outbreak of rotavirus infection among adults in an institution for rehabilitation : long-term residence in a closed community as a risk factor for rotavirus illness.2006

    • Author(s)
      Iijima Y, Iwamoto T, Nukuzuma S, Ohishi H, Hayashi K, Kobayashi N.
    • Journal Title

      Scandinavian Journal of Infectious Diseases (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Molecular characterization of a porcine Group A rotavirus strain with G12 genotype specificity.2006

    • Author(s)
      Ghosh S, Varghese V, Samajdar S, Bhattacharya SK, Kobayashi N, Naik TN.
    • Journal Title

      Archives of Virology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] RT-PCR based diagnosis revealed importance of human group B rotavirus infection in childhood diarrhoea.2006

    • Author(s)
      Barman P, Ghosh S, Samajdar S, Mitra U, Dutta P, Bhattacharya SK, Krishnan T, Kobayashi N, Naik TN.
    • Journal Title

      Journal of Clinical Microbiology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Proportion of sporadic gastroenteritis cases caused by rotavirus,norovirus,adenovirus,and bacteria in Japan from January 2000 to December 2003.2005

    • Author(s)
      Sumi A, Kobayashi N, Ohtomo N.
    • Journal Title

      Microbiology and Immunology 49

      Pages: 745-756

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Proportion of sporadic gastroenteritis cases caused by rotavirus, norovirus, adenovirus, and bacteria in Japan from January 2000 to December 2003.2005

    • Author(s)
      Sumi A, Kobayashi N, Ohtomo N.
    • Journal Title

      Microbiology and Immunology 49

      Pages: 745-756

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Genetic analysis of group B human rotaviruses detected in Bangladesh in 2000 and 2001.2004

    • Author(s)
      Ahmed MU, Kobayashi N, et al.
    • Journal Title

      Journal of Medical Virology 72

      Pages: 149-155

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Genetic analysis of group B human rotaviruses detected in Bangladesh in 2000 and 20012004

    • Author(s)
      Ahmed MU, Kobayashi N, Wakuda M, Sanekata T, Taniguchi K, Kader A, Naik TN, Ishino M, Alam MM, Kojima K, Mise K, Sumi A.
    • Journal Title

      Journal of Medical Virology 72

      Pages: 149-155

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Genetic diversity and molecular epidemiology of rotaviruses.2003

    • Author(s)
      Kobayashi N, ed.
    • Total Pages
      117
    • Publisher
      Research Signpost
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Genetic diversity and molecular epidemiology of rotaviruses.2003

    • Author(s)
      Kobayashi N, ed.
    • Publisher
      Research Signpost, Trivandrum, India
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2007-12-13  

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