2004 Fiscal Year Final Research Report Summary
Molecular biological Study about Recovery from hemiplagia on the model of rat cerebral thrombosis
| Project/Area Number |
15500367
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kagoshima University |
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Principal Investigator |
IKEDA Satoshi Kagoshima University, Graduate school of Medical and Dental Sciences, Research associate, 大学院・医歯学総合研究科, 助手 (00343369)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Akira Kagoshima University, University Hospital, Faculty of Medicine and Dentistry, Research associate, 医学部・歯学部附属病院, 助手 (40347109)
TANAKA Nobuyuki Kagoshima University, University Hospital, Faculty of Medicine and Dentistry, Professor, 医学部・歯学部附属病院, 教授 (40041454)
NAKAGAWA Shiro Kagoshima University, Graduate school of Medical and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (70073666)
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| Project Period (FY) |
2003 – 2004
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| Keywords | stroke / reorganization / neurotrophic factors / rehabilitation medicine / rat |
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| Research Abstract |
This study is to investigate the molecular biological mechanism about muscle strengthening and to clarify the factors concerning to muscle strengthening. Muscle strengthening training is one of the most important treatment procedure in the rehabilitation medicine. However, there are very few study about muscle strengthening on rehabilitation medicine from the view point of molecular biology. We investigate the muscle strengthening training as the gene transcription and protein synthesis and discover the efficient method to muscle strengthening. Almost former researches concerned about muscle tension or muscle hypertrophy character of muscle fibers. We have studied the expression of immediate early gene "c-fos" and muscle specific transcription factor "myogenin" on stretching in the skeletal muscle by northern blotting method. In this study we examined the rehabilitative effects on skeletal muscle using real time RT-PCR method. There is significant increase of expression of mechano-growth factor on the skeletal muscle treated with anabolic steroid and the expression of mechano-growth factor and glial cell derived neurotrophic factor are increased on repetitive stretching but not on static stretching.
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