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2004 Fiscal Year Final Research Report Summary

Design, synthesis and property of peptide mimics having inhibition effect of reducing musclar strength

Research Project

Project/Area Number 15510177
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Living organism molecular science
Research InstitutionThe University of Tokushima

Principal Investigator

NEMOTO Hisao  The University of Tokushima, Division of Health Biosciences, Associate Professor, 大学院・ヘルスバイオサイエンス研究部, 助教授 (30208293)

Co-Investigator(Kenkyū-buntansha) NIKAWA Takeshi  The University of Tokushima, Division of Health Biosciences, Associate Professor, 大学院・ヘルスバイオサイエンス研究部, 助教授 (20263824)
SHIBUYA Masayuki  The University of Tokushima, Vice President, 副学長
Project Period (FY) 2003 – 2004
KeywordsMasked Acyl Cyanide / peptide mimics / ubiquitin / umpolung / correspondence of an aging society / correspondence of the space age / inhibition effect of reducing musclar strength
Research Abstract

Development of compounds having inhibition effect of reducing muscular strength is one of the important propositions for various fields such as efficient rehabilitation in society for aged inpatients, or the maintenance of muscle of people engaging long-period spaceship activity. Nikawa, one of the investigators, discovered that several dipeptides inhibited the reduction of muscular strength. Nemoto, the head investigator, developed an efficient reagent, Masked Acyl Cyanide reagent (MAC reagent). MAC reagent enabled us to efficiently synthesize peptide mimics. The key reaction by MAC reagent proceeds in excellent chemical yield under mild conditions. We have succeeded the synthesis of five peptide mimics by using MAC reagent. Property of the five compounds are now examined by Nikawa. Nemoto also developed a novel synthetic route for the synthesis of MAC reagents via short steps without expensive reagents comparing with previously reported methods. By this new method, acylated MAC reagents were newly synthesized. MAC reagents will be soon commercially available by a reagent company. Nemoto developed new chemical reactions for the synthesis of alpha-acyloxy esters and alpha-amino esters by using the acylated MAC reagents.

  • Research Products

    (16 results)

All 2005 2004 2003

All Journal Article (16 results)

  • [Journal Article] Synthesis of a water-soluble molecular tweezer and a recognition study in an aqueous media2005

    • Author(s)
      Nemoto, Hisao
    • Journal Title

      Tetrahedron Letters 46

      Pages: 551-553

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Synthesis of a water-soluble molecular tweezer and a recognition study in an aqueous media2005

    • Author(s)
      Nemoto, Hisao, Kawano, Tomoaki, Ueji, Nobuo, Sakamoto, Nobutaka, Araki, Takaaki, Miyoshi, Norikazu, Suzuki, Ichiro, Shibuya, Masayuki
    • Journal Title

      Tetrahedron Lett. 46

      Pages: 551-553

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Synthesis and DNA damaging ability of enediyne model compounds possessing photo-triggering devices2004

    • Author(s)
      Suzuki, Ichiro
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters 14

      Pages: 2959-2962

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] MAC反応剤-簡便な1炭素増炭型3成分連結反応-2004

    • Author(s)
      根本尚夫
    • Journal Title

      有機合成化学協会誌 62

      Pages: 347-354

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Synthesis and DNA damaging ability of enediyne-polyamine conjugates2004

    • Author(s)
      Suzuki, Ichiro
    • Journal Title

      Tetrahedron Letters 45

      Pages: 1955-1959

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Highly efficient chiral resolution and determination of absolute configuration of 2-alkanols by using a cyclopenta[b]furan derivative2004

    • Author(s)
      Nemoto, Hisao
    • Journal Title

      Tetrahedron Letters 45

      Pages: 1667-1670

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Developments of enediyne model compounds generating biradicals with an enhanced radical character-regulation of triggering devices2004

    • Author(s)
      Suzuki, Ichiro
    • Journal Title

      Heterocycles 62

      Pages: 503-519

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] MAC reagents : Three-components coupling reaction with one carbon homologation2004

    • Author(s)
      Nemoto, Hisao
    • Journal Title

      Yuki Gosei Kagaku Kyokaishi 62

      Pages: 347-354

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Developments of enediyne model compounds generating biradicals with an enhanced radical character-regulation of triggering devices2004

    • Author(s)
      Suzuki, Ichiro, Shigenaga, Akira, Nemoto, Hisao, Shibuya, Masayuki
    • Journal Title

      Heterocycles 62

      Pages: 503-519

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Synthesis and DNA damaging ability of enediyne-polyamine conjugates2004

    • Author(s)
      Suzuki, Ichiro, Shigenaga, Akira, Nemoto, Hisao, Shibuya, Masayuki
    • Journal Title

      Tetrahedron Lett. 45

      Pages: 1955-1959

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Highly efficient chiral resolution and determination of absolute configuration of 2-alkanols by using a cyclopenta[b]furan derivative2004

    • Author(s)
      Nemoto, Hisao, Tsutsumi, Hiroe, Yuzawa, Satomi, Peng, Xian, Zhong, Weihui, Xie, Jun, Miyoshi, Norikazu, Suzuki, Ichiro, Shibuya, Masayuki
    • Journal Title

      Tetrahedron Lett. 45

      Pages: 1667-1670

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Synthesis and DNA damaging ability of enediyne model compounds possessing photo-triggering devices2004

    • Author(s)
      Suzuki, Ichiro, Uno, Shinsaku, Tsuchiya, Yuko, Shigenaga, Akira, Nemoto, Hisao Shibuya, Masayuki
    • Journal Title

      Bioorg.Med.Chem.Lett. 14

      Pages: 2959-2962

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Preparation of glycerol derivatives for modification of physiologically active polypeptides2004

    • Author(s)
      Nemoto, Hisao, Yamasaki, Motoo, Suzawa, Toshiyuki, Yamaguchi, Hiroyuki
    • Journal Title

      PCT Int.Appl. 80

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Process for preparation and separation of 2-oxabicyclo[3.3.0]octane derivatives2004

    • Author(s)
      Sakamoto, Kei, Nakano, Yasuyuki, Kondou, Yoshihisa, Yamada, Toshiro, Nemoto, Hisao
    • Journal Title

      PCT Int.Appl. 63

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Synthesis, reactions and DNA damaging abilities of 10-membered enediyne-sulfone and related compounds2003

    • Author(s)
      Suzuki, Ichiro, Shigenaga, Akira, Manabe, Atsuo, Nemoto, Hisao, Shibuya, Masayuki
    • Journal Title

      Tetrahedron 59

      Pages: 5691-5704

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Process for preparation of dicyanomethyl esters2003

    • Author(s)
      Nemoto, Hisao
    • Journal Title

      PCT Int.Appl. 24

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2006-07-11  

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