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2005 Fiscal Year Final Research Report Summary

Theoretical study on microdomains in biomembranes

Research Project

Project/Area Number 15540395
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biophysics/Chemical physics
Research InstitutionTokyo Metropolitan University

Principal Investigator

KOMURA Shigeyuki  Tokyo Metropolitan University, Department of Chemistry, Associate Professor, 都市教養学部理工学系, 助教授 (90234715)

Project Period (FY) 2003 – 2005
Keywordsmicrodomain / raft / lipid / cholesterol / soft matter
Research Abstract

In an effort to understand "rafts" in biological membranes, we propose phenomenological models for saturated and unsaturated lipid mixtures, and lipid plus cholesterol mixtures. We consider simple couplings between the local composition and internal membrane structure, and their influence on transitions between liquid and gel membrane phases. Assuming that the gel transition temperature of the saturated lipid is shifted by the presence of the unsaturated lipid, and that cholesterol acts as an external field on the chain melting transition, a variety of phase diagrams are obtained. Our results also apply to regions in the ternary phase diagram of lipid/lipid/cholesterol systems.
We propose models for the first-order unbinding transition of lyotropic lamellae in surfactant solutions. The coupling between the surfactant volume fraction and the elastic degree of freedom is considered so that the net attractive interaction between the surfactant molecules is enhanced. The elastic degree of freedom can be either (i) a membrane elastic degree of freedom, or (ii) a bulk elastic degree of freedom. The phase behaviors of these two models are analyzed. For the both cases, the unbinding transition becomes first-order when the coupling is strong enough. We determine the associated preunbinding line which separates two lamellar phases having different repeat distances.

  • Research Products

    (12 results)

All 2006 2005 2004 2003

All Journal Article (12 results)

  • [Journal Article] Unbinding and Preunbinding in Surfactant Solutions2006

    • Author(s)
      S.Komura, N.Shimokawa, T.Kato
    • Journal Title

      J. Chem. Phys. 124

      Pages: 034906

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Unbinding and Preunbinding in Surfactant Solutions2006

    • Author(s)
      S.Komura, N.Shimokawa, T.Kato
    • Journal Title

      J.Chem.Phys. 124

      Pages: 034906

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Phase Behavior of Three-Component Lipid Mixtures2005

    • Author(s)
      S.Komura, H.Shirotori, P.D.Olmsted
    • Journal Title

      J. Phys. : Condens. Matter 17

      Pages: S2951-S2956

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Buckling of Spherical Shells Adhering onto a Rigid Substrate2005

    • Author(s)
      S.Komura, K.Tamura, T.Kato
    • Journal Title

      Eur. Phys. J. E 18

      Pages: 343-358

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Phase Behavior of Three-Component Lipid Mixtures2005

    • Author(s)
      S.Komura, H.Shirotori, P.D.Olmsted
    • Journal Title

      J.Phys. : Condens.Matter 17

      Pages: S2951-S2956

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Buckling of Spherical Shells Adhering onto a Rigid Substrate2005

    • Author(s)
      S.Komura, K.Tamura, T.Kato
    • Journal Title

      Eur.Phys.J.E 18

      Pages: 343-358

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Lateral Phase Separation in Mixtures of Lipids and Cholesterol Systems2004

    • Author(s)
      S.Komura, H.Shirotori, P.D.Olmsted, D.Andelman
    • Journal Title

      Europhys. Lett. 67

      Pages: 321-327

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Lateral Phase Separation in Mixtures of Lipids and Cholesterol Systems2004

    • Author(s)
      S.Komura, H.Shirotori, P.D.Olmsted, D.Andelman
    • Journal Title

      Europhys.Lett. 67

      Pages: 321-327

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Phase Behavior of Charged Lipid Bilayer Membranes with Added Electrolyte2003

    • Author(s)
      S.Komura, H.Shirotori, T.Kato
    • Journal Title

      J. Chem. Phys 119

      Pages: 1157-1164

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The Unbinding Transition of Mixed Fluid Membranes2003

    • Author(s)
      S.Komura, D.Andelman
    • Journal Title

      Europhys. Lett. 64

      Pages: 844-850

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Phase Behavior of Charged Lipid Bilayer Membranes with Added Electrolyte2003

    • Author(s)
      S.Komura, H.Shirotori, T.Kato
    • Journal Title

      J.Chem.Phys. 119

      Pages: 1157-1164

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The Unbinding Transition of Mixed Fluid Membranes2003

    • Author(s)
      S.Komura, D.Andelman
    • Journal Title

      Europhys.Lett. 64

      Pages: 844-850

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2008-05-27  

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