2004 Fiscal Year Final Research Report Summary
Interaction between cholesterol-bearing amphiphilic polyelectrolytes and surfactants
| Project/Area Number |
15550112
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Polymer chemistry
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| Research Institution | Faculty of Engineering, Fukui University |
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Principal Investigator |
MORISHIMA Yotaro Fukui University, Faculty of Engineering, Professor, 工学部, 教授 (70028249)
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| Co-Investigator(Kenkyū-buntansha) |
YUSA Shin-ichi University of Hyogo, Department of Materials and Science, Research assistant, 大学院・工学研究科, 助手 (00301432)
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| Project Period (FY) |
2003 – 2004
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| Keywords | Amphiphilic Polyelectrolyte / Cholesteryl group / Bile acid / Aggregation / Hydrophobic interaction / Nonionic surfactant / Micelle / Fluorescence |
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| Research Abstract |
A hydrophobically modified polysulfonate bearing a small mole percent (5 mol %) of cholesteryl moieties forms an intermolecularly bridged flower micelle in water, arising from intermolecular associations of the polymer-bound cholesteryl groups. Binding of sodium cholate (SC) to this polymer micelle in water was investigated using ^1H NMR spin-spin relaxation time, static light scattering, quasi-elastic light scattering, and fluorescence techniques. The intermolecular association of the polymer-bound cholesteryl groups was disrupted, to some extent, by the addition of SC, resulting in the formation of complexes of the polymer-bound cholesteryl groups and SC. To investigate interactions between the polymer-bound cholesteryl groups and SC, the cholesteryl groups were labeled with a naphthalene moiety. Fluorescence spectra of the naphthalene labels and NMR spin-spin relaxation time data suggested that interactions between the aggregates of the polymer-bound cholesteryl groups and SC occurred below a critical micelle concentration of SC in water.
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