2004 Fiscal Year Final Research Report Summary
Neurobiology of hydra primitive nervous system
| Project/Area Number |
15570070
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Fukuoka Women's University |
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Principal Investigator |
KOIZUMI Osamu Fukuoka Women's University, Environmental Science, 人間環境学部, 教授 (50094777)
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| Co-Investigator(Kenkyū-buntansha) |
MINOBE Sumiko Fukuoka Women's University, Environmental Science, 人間環境学部, 助手 (80190718)
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| Project Period (FY) |
2003 – 2004
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| Keywords | diffuse nervous system / hydra / nerve net formation / developmental neurobiology / peptide / immunihistochemis / antibody production / nerve differentiation |
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| Research Abstract |
(1)Structure of the diffuse nervous system of hydra (neuroanatomy)
Large scale screening of peptide signal molecules in hydra, many novel peptides were identified We produced antibodies against every peptides. Using these antibodies, we did chemical anatomy of hydra nervous system.
(2)Function of the diffuse nervous system of hydra (neurophysiology, behaviorall physidogy)
We demonstrated that the simple nervous system of hydra had abilities comparable to central nervous system of the higher animals. We examined our hypothesis nerve ring in hydra is the originn of the central nervous system of higher nervous system We identified a function of the nerve ring, which was the coordination of the simulutanous tentacle movement, crumpling..
(3)Formation of the diffuse nmous system of hydra (developmental neurobiology)
We identified two types of peptides, one is Hym355 activating nerve differentiation of hydra, and the other is LPW peptide family inhibiting nerve differentiation of hydra. Hym355 was a neuropeptide, but LPW family was epitheliopeptides. These peptides were demonstrated to affect on the nerve stem cells, interstitial celsl.
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[Journal Article] Biochemical evaluation of hormonal activity of endocrine disruptors by sensing the estrogen receptor conformation changes.2003
Author(s)
Asai, D., Koizumi, O., Mohri.S., Nakai, M., Yakabe, Y., Tokunaga, T, Nose, T., Shimohigashi, Y.
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Journal Title
Peptide Science 2002
Pages: 127-130
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Identification of a vasopressin-like immunoreactive substance in hydra.2003
Author(s)
Morishita, F., Nitagai, Y., Furukawa, Y., Matsushima, O., Takahashi, T., Hatta, M., Fujisawa, T., Tunamoto, T., Koizumi, O.
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Journal Title
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Identification of a new member of the GLWamide peptide family : physiological activity and cellular localization in cnidarian polyps.2003
Author(s)
Takahashi, T., Kobayakawa, Y., Muneoka, Y., Fujisawa, Y., Mohri, S., Hatta, M., Shimizu, H., Fujisawa, T., Sugiyama, T., Takahara, M., Yanagi, K., Koizumi, O.
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Journal Title
Comp.Biochem.Physiol.(B) 135
Pages: 309-324
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Nuclear receptor binding assay by sensing changes in receptor conformation.2001
Author(s)
Shimohigashi, Y., Asai, D., Yakabe, Y., Takatsuki, M., Nose, T., Sagkaguchi, K., Mohri, S., Koizumi, O.
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Journal Title
Environ.Sci. 8
Pages: 3-4
Description
「研究成果報告書概要(欧文)」より
