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2004 Fiscal Year Final Research Report Summary

The development of reconstructive medical techniques with mesenchymal stem cells

Research Project

Project/Area Number 15580074
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied biochemistry
Research InstitutionNagoya University

Principal Investigator

KADOWAKI Tatsuhiko  Nagoya University, Graduate School of Bioagrieultural Sciences, Associate Professor, 大学院・生命農学研究科, 助教授 (90313973)

Co-Investigator(Kenkyū-buntansha) KITAGAWA Yasuo  Nagoya University, Graduate School of Bioagrieultural Sciences, Professor, 大学院・生命農学研究科, 教授 (50101168)
Project Period (FY) 2003 – 2004
KeywordsWnt family / Mesenchymal stem cells / Differentiation / Porcupine
Research Abstract

L-glutamate is a major neurotransmitter at the excitatory synapses in the vertebrate brain. It is also the excitatory neurotransmitter at neuromuscular junctions in insects, however its functions in their brains remain to be established. We identified and characterized two different subtypes (AmGluRA and AmGluRB) of metabotropic glutamate receptors (mGluRs) from an eusocial insect, honeybee. Both AmGluRA and AmGluRB form homodimers independent on disulfide bonds, and bind ^3H-glutamate with K_n values of 156.7 and 80.7 nM, respectively. AmGluRB is specifically expressed in the brain, while AmGluRA is expressed in the brain and other body parts, suggesting that AmGluRA is also present at the neuromuscular junctions. Both mGluRs are expressed in the mushroom bodies and the brain regions of honeybees, where motor neurons are clustered. Their expression in the brain apparently overlaps, suggesting that they may interact with each other to modulate the glutamatergic neurotransmission.

  • Research Products

    (12 results)

All 2004 2003

All Journal Article (12 results)

  • [Journal Article] The changes of gene expression in honeybee (Apis mellifera) brains associated with ag2004

    • Author(s)
      Tsuchimoto M, et al.
    • Journal Title

      Zool.Sci. 21

      Pages: 23-28

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Characterization of the two distinct subtypes of metabotropic2004

    • Author(s)
      Funada M. et al.
    • Journal Title

      Neuroscience Letters 359

      Pages: 190-194

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The changes of gene expression in honeybee (Apis mellifera) brains associated with ages.2004

    • Author(s)
      Tsuchimoto M, Aoki M, Takada M, Kanou Y, Sasagawa H, Kitagawa Y, Kadowaki T.
    • Journal Title

      Zool.Sci. 21

      Pages: 23-28

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Characterization of the two distinct subtypes of metabotropic glutamate receptors from honeybee, Apis mellifera.2004

    • Author(s)
      Funada M, Yasuo S, Yoshimura T, Ebihara S, Sasagawa H, Kitagawa Y, Kadowaki T.
    • Journal Title

      Neurosci.Lett. 359

      Pages: 190-194

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Misexpression of mouse porcupine isoforms modulates the differentiation of P19 embry2003

    • Author(s)
      Tanaka K, Kitagawa Y, Kadowaki T
    • Journal Title

      Cell Biol.Int. 27

      Pages: 549-557

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The expression of genes encoding visual components is regulated by a circadian clock2003

    • Author(s)
      Sasagawa H, Narita R, Kitagawa Y, K
    • Journal Title

      Eur.J.Neurosci. 17

      Pages: 963-970

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Drosophila hemolectin gene is expressed in embryonic and larval hemocytes and its kn2003

    • Author(s)
      Goto A, Kadowaki T, Kitagawa Y
    • Journal Title

      Dev.Biol. 264

      Pages: 582-591

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 動物行動と視覚遺伝子の発現制御-ミツバチをモデルシステムにした解析-2003

    • Author(s)
      笹川浩美, 門脇辰彦
    • Journal Title

      化学と生物 41

      Pages: 359-365

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Misexpression of mouse porcupine isoforms modulates the differentiation of P19 embryonal carcinoma cells.2003

    • Author(s)
      Tanaka K, Kitagawa Y, Kadowaki T.
    • Journal Title

      Cell Biol.Int. 27

      Pages: 549-557

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The expression of genes encoding visual components is regulated by a circadian clock, light environment and age in the honeybee (Apis mellifera).2003

    • Author(s)
      Sasagawa H, Narita R, Kitagawa Y, Kadowaki T.
    • Journal Title

      Eur.J.Neurosci. 17

      Pages: 963-970

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Drosophila hemolectin gene is expressed in embryonic and larval hemocytes and its knock down causes bleeding defects.2003

    • Author(s)
      Goto A, Kadowaki T, Kitagawa Y.
    • Journal Title

      Dev.Biol. 264

      Pages: 582-591

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The causal relationship between animal behavior and regulation of visual gene expression2003

    • Author(s)
      Sasagawa H, Kadowaki T.
    • Journal Title

      Kagakutoseibutu 41

      Pages: 359-365

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2006-07-11  

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