2004 Fiscal Year Final Research Report Summary
Development of a novel sugar linkage and sugar-related bioactive compounds
| Project/Area Number |
15590023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Teikyo University |
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Principal Investigator |
TAKAHASHI Hideyo Teikyo University, Faculty of Pharmaceutical Sciences, Associate Professor, 薬学部, 助教授 (10266348)
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| Co-Investigator(Kenkyū-buntansha) |
NAMME Rie Teikyo University, Faculty of Pharmaceutical Sciences, Research Assistant, 薬学部, 助手 (70349257)
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| Project Period (FY) |
2003 – 2004
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| Keywords | Coyolosa / ether-linked sugar / ether bonding / reductive etherification / hypogelycemic activit |
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| Research Abstract |
Coyolosa, a new natural product isolated from the Acrocomia mexicana root, has shown a significant effect on fasting blood glucose levels. While there can be no doubt that Coyolosa has a structure with two pyranoses linked at each of their 6-positions, it is less obvious that the stereochemistry of its pyranose moiety corresponds to the proposed structure. In this communication, we report a novel synthesis of 6, 6'-ether-connected pyranoses. Also, we reconsidered the stereochemistry of the proposed structure of Coyolosa based on the structure-activity relationships (SAR) studies. This is the first synthesis of ether-connected sugar based on an acetalization-reduction procedure.
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