2005 Fiscal Year Final Research Report Summary
Identification and functional analyses of CO_2-sensing cells in the central respiratory chemoreceptor
| Project/Area Number |
15590190
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Keio University |
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Principal Investigator |
OKADA Yasumasa Keio University, Department of Medicine, Associate Professor, 医学部, 助教授 (80160688)
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| Co-Investigator(Kenkyū-buntansha) |
KUWANA Shun-ichi Teikyo University, Department of Medicine, Assistant Professor, 医学部, 講師 (70129998)
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| Project Period (FY) |
2003 – 2005
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| Keywords | respiratory control / central chemosensitivity / propofol / brainstem / respiratory neuronal network / voltage imaging / GABA / muscle relaxant |
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| Research Abstract |
In this research project we have studied the function and anatomy of the neural substrate for the central respiratory chemoreception and central respiratory control.
In order to identify the functional role of an important neurotransmitter GABA in central respiratory control, we used GABA-synthesizing enzyme (GAD) gene-targeted mice, and found that GABA is necessary in the maintenance of stable respiratory output (Kuwana et al. 2003 ; 2004 ; 2006). We also found that respiratory depression by propofol is induced by its GABA-like inhibitory action (Kashiwagi et al. 2004 ; 2004).
We applied a voltage imaging technique to an in vitro brainstem preparation, and succeeded functional mapping of chemosensitive regions. We reported that the pontine A5 region has intrinsic chemosensitivity (Ito et al. 2004).
On the basis of our hypothesis that nicotinic acetylcholine receptor is importantly involved in central respiratory chemoreception, we analyzed the effects of non-depolarizing muscle relaxants on chemoresponsiveness in vitro. We first reported that non-depolarizing muscle relaxants inhibit respiratory activity in the brainstem (Sakuraba et al. 2003 ; 2005).
We summarized the results of our studies, and have proposed our theories that potassium channels play a key role as the chemosensor in chemoreceptor cells (Oyamada et al. 2006) and that specific small cells surrounding fine vessels in the superficial ventral medulla are primary chemoreceptor cells (Okada et al. 2006).
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[Book] 呼吸の事典2006
Author(s)
桑名俊一
Total Pages
728
Publisher
朝倉書店
Description
「研究成果報告書概要(和文)」より
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