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2004 Fiscal Year Final Research Report Summary

Title of project : Mechanisms underlying angiotensin II-stimulated production of proinflammatory cytokines : Are transcription factors involved?

Research Project

Project/Area Number 15590209
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionNational University Corporation Tottori University

Principal Investigator

WATANABE Tatsuo  Tottori University, Faculty of Medicine, Professor, 医学部, 教授 (60182929)

Co-Investigator(Kenkyū-buntansha) MIYOSHI Michio  Tottori University, Faculty of Medicine, Research Associate, 医学部, 助手 (20093627)
NAGATA Katumi  Tottori University, Graduate School of Medical Science, Research Associate, 医学系研究科, 助手 (30208011)
Project Period (FY) 2003 – 2004
Keywordsangiotensin II / AT_1 receptor / NF-κB / AP-1 / LPS / IL-1 / rat
Research Abstract

We recently reported an involvement of angiotensin II(ANG II) and ANG type 1(AT1) receptor in the hepatic, splenic and brain expression of IL-1ss induced in rats by lipopolysaccharide(LPS). We investigated whether ANG II contributes to the IL-1 production through its effect on the activation of proinflammatory transcription factors, NF-κB and AP-1, induced in the rat's liver and spleen by LPS. Surprisingly, LPS induced a marked increase in the hepatic activation of NF-κB, an effect that was significantly enhanced (rather than reduced) by pre-treatment with the ACE inhibitor and AT1-receptor antagonist. Furthermore, the LPS-induced expression of splenic AP-1 was significantly augmented by pre-treatment with the AT1-receptor antagonist. The present results suggest that endogenous ANG II or AT1 receptor suppress the activation of the hepatic or splenic transcription factors in LPS-treated rats. Our results does not seem to support the idea that NF-κB and AP-1 play a key role in the ANG II-enhanced production of proinflammatory cytokines induced by LPS in rats.

  • Research Products

    (6 results)

All 2004 2003

All Journal Article (6 results)

  • [Journal Article] Angiotensin II : its effects on fever and hypothermia in systemic inflammation.2004

    • Author(s)
      Watanabe T, Miyoshi M, Imoto T
    • Journal Title

      Frontiers in Bioscience 9

      Pages: 438-447

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The effect of central injection of angiotensin-converting enzyme inhibitor and the angiotensin type 1 receptor antagonist on the induction by lipopolysaccharide of fever and brain interleikin-1β response in rats.2004

    • Author(s)
      Shimizu H, Miyoshi M, Matsumoto K, Goto O, Imoto T, Watanabe T
    • Journal Title

      Journal of Pharmacology and Experimental Therapeutics 308

      Pages: 865-873

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Angiotensin II : its effects on fever and hypothermia in systemic inflammation.2004

    • Author(s)
      Watanabe T, Miyoshi M, Imoto T.
    • Journal Title

      Frontiers in Bioscience 9

      Pages: 438-447

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The effect of central injection of angiotensin-converting enzyme inhibitor and the angiotensin type 1 receptor antagonist on the induction by lipopolysaccharide of fever and brain interleikin-1ss response in rats.2004

    • Author(s)
      Shimizu H, Miyoshi M, Matsumoto K, Goto O, Imoto T, Watanabe T.
    • Journal Title

      Journal of Pharmacology and Experimental Therapeutics 308

      Pages: 865-873

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] ANG II is involved in the LPS-induced production of proinflammatory cytokines in dehydrated rats.2003

    • Author(s)
      Miyoshi M, Nagata K, Imoto T, Goto O, Ishida A, Watanabe T
    • Journal Title

      American Journal of Physiology 284

      Pages: R1092-R1097

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] ANG II is involved in the LPS-induced production of proinflammatory cytokines in dehydrated rats.2003

    • Author(s)
      Miyoshi M, Nagata K, Imoto T, Goto O, Ishida A, Watanabe T.
    • Journal Title

      American Journal of Physiology 284

      Pages: R1092-R1097

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2006-07-11  

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