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2004 Fiscal Year Final Research Report Summary

Molecular Pathology on Atherosclerosis Suppression in the Left Anterior Descending Coronary Artery due to Shear Stress under Myocardial Bridge

Research Project

Project/Area Number 15590320
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionToho University

Principal Investigator

ISHII Toshiharu  Toho University, School of Medicine, Department of Pathology, Professor of Pathology, 医学部, 教授 (30101893)

Co-Investigator(Kenkyū-buntansha) AKASAKA Yoshikiyo  Toho University, Same as the above, Associate Professor, 医学部, 助教授 (60202511)
ISHIKAWA Yukio  Toho University, Same as the above, Assistant Professor, 医学部, 講師 (30276894)
Project Period (FY) 2003 – 2004
KeywordsMyocardial bridge / Coronary artery / Atherosclerosis Suppression / Histomorphometry / Blood Coagulation / Fibrinolysis / Shear Stress
Research Abstract

I.Histomorphometric Study
It is carried on the 200 consecutive LADs having myocardial bridge(MB) and 100 LADs having no MB. All the LADs were cross-psectioned with the intervals of 5 mm. After HE and EVG stainings for light microscopy, they were subjected to histomorphometric study. The anatomic properties of location of entrance, length and myocardial thickness of MB in the LAD were measured by the computer assisted system. Under MB, the extent of coronary atherosclerosis was always suppressed,. The myocardial thickness of MB was innassociation with MB length. The myocardial thickness of MB had significant effect on atherosclerosis suppression under MB segment. The anatomical properties of MB played significant role on atherosclerosis suppression.
II.Immunohistochemistry
Using the antibodies of tissue factor, tissue plasminogen activator and plasminogen-activator inhibitor 1, immunohistochemistry was carried out on the above specimens. Blood coiagulative factors of the former two were down-regulated and fibrinolysis factor of the latter one was up-regulated in the coronary segment under MB. These changes were rcaused by the changes of shear stress across MB, and finally resulted in atherosclerosis under MB segment in the LAD.

  • Research Products

    (6 results)

All 2005 2004

All Journal Article (6 results)

  • [Journal Article] Role of macrophage and smooth muscle cell apoptosis in association with oxidized LDL in the atherosclerotic development2005

    • Author(s)
      Akishima Y, Ishii T et al.
    • Journal Title

      Mod Pathol 18

      Pages: 365-373

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Role of macrophage and smooth muscle cell apoptosis in association with oxidized LDL in the atherosclerotic development2005

    • Author(s)
      Akishima Y, Ishii et al.
    • Journal Title

      Mod Pathol 18

      Pages: 365-373

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Immunohistochemical detection of human small lymphatic vessels under normal and pathologic conditions using the LYVE-1 antibody2004

    • Author(s)
      Akishima Y, Ishii T et al.
    • Journal Title

      Virchows Arch 444

      Pages: 153-157

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 左冠状動脈前下行枝における心筋架橋の病理解剖学的意義2004

    • Author(s)
      石川由起雄, 石井壽晴
    • Journal Title

      診断病理 21

      Pages: 261-269

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Immunohistochemical detection of human small Lymphatic vessels under normal and pathologic conditions using the LYVE-1 antibody2004

    • Author(s)
      Akishima Y, Ishii T et al.
    • Journal Title

      Virchows Arch 444

      Pages: 153-157

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Significance of pathological autopsy of myocardial bridge in the left anterior descending coronary artery2004

    • Author(s)
      Ishikawa Y, Ishii T et al.
    • Journal Title

      Diagnostic Pathology 21

      Pages: 261-269

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2006-07-11  

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