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2004 Fiscal Year Final Research Report Summary

Tumor development mechanism and its risk evaluation in Werner syndrome

Research Project

Project/Area Number 15590326
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionJapanese Foundation for Cancer Research

Principal Investigator

ISHIKAWA Yuichi  Japanese Foundation for Cancer Research, The Cancer Institute, Department of Pathology, Member and Chief, 癌研究所・病理部, 部長 (80222975)

Co-Investigator(Kenkyū-buntansha) SHIMIZU Hiroyuki  Gifu University, Faculty of Medicine, Professor, 医学部, 教授 (90073139)
Project Period (FY) 2003 – 2004
KeywordsWerner syndrome / aging / malignant tumors / hereditary diseases / tumor spectrum / tumorigenesis / tumor risk / non-epithelial tumors
Research Abstract

Werner syndrome is an interesting model for researches both of aging and cancer. We have so far revealed that six kinds of rare tumors, i.e. thyroid carcinoma, bone sarcoma, soft part sarcoma, myeloid disorders/MDS, meningioma and melanoma, were increased and that tumors common in general populations were not increased in Werner syndrome.
In the current study, we have investigated (1) relationships between WRN helicase deficit and tumorigenesis and (2) evaluation of tumor risk in Werner syndrome.
Regarding the first issue, for further analysis in the future, we collected seven cases of lung malignant tumors because relations between tumor causes and histology/genetic changes were relatively well established in lung tumors.
For the second issue, we gathered data and/or materials of 133 non-epithelial (including 110 malignant) and 75 epithelial tumors from our related institutions and research collaborators or through examining public data bases such as the PubMed and the Igaku-Chuo-Zasshi. As a result, we updated our tumor files, providing the new tumor spectrum : 37 soft part sarcoma (including subcutaneous ones), 34 melanomas, 23 leukemia/MDS, 21 meningiomas, 14 bone sarcomas, 4 brain tumors as well as 28 thyroid carcinomas, 10 skin carcinomas, 7 liver carcinomas, 6 breast carcinomas, 6 gastric carcinomas, 5 lung carcinomas, 1 colonic carcinoma and no prostatic carcinoma. As compared with the previous statistics published in 1996, increased soft part sarcoma and skin cancers other than melanoma were noted. Particularly, it was interesting that we had now as many as 39 malignant tumors related to skin, including subcutaneous ones. Details were 23 melanomas, 5 basal cell carcinomas, 3 squamous cell carcinomas, 1 sebaceous gland carcinoma, 1 Bowen's disease, and 1 carcinoma NOS. Benign skin tumors were 1 solar keratosis, 1 nevocellular nevus, and subcutaneous sarcomas included 2 malignant fbrous histioctomas and 1 acute T cell leukemia.

  • Research Products

    (2 results)

All 2005

All Journal Article (2 results)

  • [Journal Article] 成人型早老症Werner症候群における癌2005

    • Author(s)
      石川雄一
    • Journal Title

      細胞 37

      Pages: 1532-1535

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Tumors arising in Werner syndrome2005

    • Author(s)
      Yuichi Ishikawa
    • Journal Title

      Saibou (Cell) 37

      Pages: 1532-1535

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2006-07-11  

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