2005 Fiscal Year Final Research Report Summary
Mesurements of extracellular concentratin change of sphingosine 1-phosphate, lipid mediator, are useful to clinical procedure of the atherogenic disease
| Project/Area Number |
15590479
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Gunma University |
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Principal Investigator |
KUWABARA Atsushi GUNMA UNIVERSITY, Faculty of Medicine, Research Associate, 医学部, 助手 (90323344)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Masami GUNMA UNIVERSITY, Faculty of Medicine, Professor, 大学院・医学系研究科, 教授 (30241871)
OKAJIMA Fumikazu GUNMA UNIVERSITY, Institute for Molecular and Cellular Regulatin, Professor, 生体調節研究所, 教授 (30142748)
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| Project Period (FY) |
2003 – 2005
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| Keywords | sphinaosine 1-phosphate / HDL-cholesterol / Atherosclerosis / lipoprotein |
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| Research Abstract |
We reported that extracellular sphingosine 1-phosphate (S1P) contributed to the anti-atherogenic action of high density lipoprotein (HDL) on endothelial and smooth muscle cells. We also reported the relationship of lipoprotein-associated S1Pconcentrations with cholesterol and apolipoprotein contents of lipoprotein.
・HDL-induced endothelial cell migration and survival may be mediated by the lipoprotein component S1P and the lipid receptors S1P_1 and S1P_3.
・S1P component in HDL is responsible for the inhibition of vascular smooth muscle cells (VSMC) migration through S1P_2 receptors.
・S1P in HDL was associated with lipoprotein containing apolipoprotein A-I (LpA-I) and LpA-I/LpA-II particles, and correlated with serum levels of HDL-C and apo A-I. LDL-S1P was correlated with serum levels of LDL-C and apo B. It may be useful to investigate whether or not the balance between the HDL-S1P and LDL-S1P concentration could be important in predicting the risk of coronary heart disease, similar to the balance between HDL-C and LDL-C levels.
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Research Products
(13 results)
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[Journal Article] Sphingosine 1-phosphate receptors mediate stimulatory and inhibitory signalings for expression of adhesion molecules in endothelial cells2006
Author(s)
Kimura T, Tomura H, Mogi C, Kuwbara A, Ishiwara M, Shibasawa K, Sato K, Ohwada S, Im DS, Kurose H, Ishizuka T, Murakami M, Okajima F.
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Journal Title
Cell Signal. 18
Pages: 841-850
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Sphingosine 1-phosphate receptors mediate stimulatory and inhibitory signalings for expression of adhesion molecules in endothelial cells2006
Author(s)
Kimura T, Tomura H, Mogi C, Kuwabara A, Ishiwara M, Shibasawa K, Sato K, Ohwada S, Im DS, Kurose H, Ishizuka T, Murakami M, Okajima F
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Journal Title
Cell Signal. 18
Pages: 841-850
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1.2004
Author(s)
Yamada T, Sato K, Komachi M, Malchinkhuu E, Tobo M, Kimura T, Kuwabara A, Yanagita Y, Ikeya T, Tanahashi Y, Ogawa T, Ohwada S, Morishita Y, Ohta H, ImDS, Tamoto K, Tomura H, Okajima F.
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Journal Title
J Biol Chem. 279(8)
Pages: 6595-605
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells throuah LPA1.2004
Author(s)
Yamada T, Sato K, Komachi M, Malchinkhuu E, Tobo M, Kimura T, Kuwabara A, Yanagita Y, Ikeya T, Tanahashi Y, Ogawa T, Ohwada S, Morishita Y, Ohta H, Im DS, Tamoto K, Tomura H, Okajima F
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Journal Title
J Biol Chem. 279(8)
Pages: 6595-6605
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor.2004
Author(s)
Wang JQ, Kon J, Mogi C, Tobo M, Damirin A, Sato K, Komachi M, Malchinkhuu E, Murata N, Kimura T, Kuwabara A, Wakamatsu K, Koizumi H, Uede T, Tsujimoto C, Kurose H, Sato T, Harada A, Misawa N, Tomura H, Okajima F
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Journal Title
J Biol Chem. 279(44)
Pages: 45626-45633
Description
「研究成果報告書概要(欧文)」より
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