2004 Fiscal Year Final Research Report Summary
Interaction of alcohol consumption and a single nucleotide polymorphism in aldehyde dehydrogenase 2 (ALDH2) on the susceptibility to hepatocellular carcinoma in Japanese patients with hepatitis C
| Project/Area Number |
15590507
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Hygiene
|
|---|
| Research Institution | Yamagata University |
|---|
Principal Investigator |
LI Shao Yamagata University, Dept.of Public Health, 大学院・医学系研究科, 助手 (80344787)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
WATANABE Hisayoshi Yamagata University, Dept.of Gastroenterology, 医学部, 助手 (00332536)
TAKAHASHI Tatuya Yamagata University, Dept.of Public Health, 大学院・医学系研究科, 助教授 (50304928)
FUKAO Akira Yamagata University, Dept.of Public Health, 大学院・医学系研究科, 教授 (80156736)
|
|---|
| Project Period (FY) |
2003 – 2004
|
| Keywords | Hepatitis C / Hepatocullular carcinoma / Single nucleotide polymorphism / ADH / ALDH2 |
|---|
| Research Abstract |
To evaluate the effects on HCV-related hepatocellular carcinoma (HCC) risk of an interaction between a single nucleotide polymorphism (SNP) in alcohol dehydrogenase 2 (ALDH2) gene and alcohol consumption, a hospital-based case-control study of 92 HCV-related HCC patients and 115 controls was conducted in Yamagata, Japan, between 2002 and 2004. Alcohol consumption was collected through interviews and SNP characteristic was determined by PCR-based method using DNA extracted from peripheral blood. Data on alcohol consumption level, ALDH2 genotype, and other risk factors were analyzed using multivariate logistic regression. Older age, higher serum ALT level, cirrhosis and history of smoking and drinking were significant association with HCV-related HCC, whereas no overall association was found between ALDH2 genotype and the risk of HCC development. Neither was an interaction between ALDH2 genotypes and alcohol consumption level on HCC development suggested. Our result is consistent with the observation from two Japanese studies, but opposite to others, where the ALDH2 genotype seemed to be related to HCC. These findings illustrate the importance of replicating SNP associations study.
|
