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2004 Fiscal Year Final Research Report Summary

Interaction of alcohol consumption and a single nucleotide polymorphism in aldehyde dehydrogenase 2 (ALDH2) on the susceptibility to hepatocellular carcinoma in Japanese patients with hepatitis C

Research Project

Project/Area Number 15590507
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionYamagata University

Principal Investigator

LI Shao  Yamagata University, Dept.of Public Health, 大学院・医学系研究科, 助手 (80344787)

Co-Investigator(Kenkyū-buntansha) WATANABE Hisayoshi  Yamagata University, Dept.of Gastroenterology, 医学部, 助手 (00332536)
TAKAHASHI Tatuya  Yamagata University, Dept.of Public Health, 大学院・医学系研究科, 助教授 (50304928)
FUKAO Akira  Yamagata University, Dept.of Public Health, 大学院・医学系研究科, 教授 (80156736)
Project Period (FY) 2003 – 2004
KeywordsHepatitis C / Hepatocullular carcinoma / Single nucleotide polymorphism / ADH / ALDH2
Research Abstract

To evaluate the effects on HCV-related hepatocellular carcinoma (HCC) risk of an interaction between a single nucleotide polymorphism (SNP) in alcohol dehydrogenase 2 (ALDH2) gene and alcohol consumption, a hospital-based case-control study of 92 HCV-related HCC patients and 115 controls was conducted in Yamagata, Japan, between 2002 and 2004. Alcohol consumption was collected through interviews and SNP characteristic was determined by PCR-based method using DNA extracted from peripheral blood. Data on alcohol consumption level, ALDH2 genotype, and other risk factors were analyzed using multivariate logistic regression. Older age, higher serum ALT level, cirrhosis and history of smoking and drinking were significant association with HCV-related HCC, whereas no overall association was found between ALDH2 genotype and the risk of HCC development. Neither was an interaction between ALDH2 genotypes and alcohol consumption level on HCC development suggested. Our result is consistent with the observation from two Japanese studies, but opposite to others, where the ALDH2 genotype seemed to be related to HCC. These findings illustrate the importance of replicating SNP associations study.

  • Research Products

    (2 results)

All 2004

All Journal Article (2 results)

  • [Journal Article] Transmission of hepatitis C virus quasispecies between human adults2004

    • Author(s)
      Sitao T, Watanabe H, Shao L, et al.
    • Journal Title

      Heptol Res 30・2

      Pages: 57-62

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Transmission of hepatitis C virus quasispecies between human adults2004

    • Author(s)
      Sitao T, Watanabe H, Shao L, et al.
    • Journal Title

      Hepatol Res. 30-2

      Pages: 57-62

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2006-07-11  

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