2004 Fiscal Year Final Research Report Summary
The role of PPAR γ in Gastrointestinal disease
| Project/Area Number |
15590669
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Yokohama City University |
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Principal Investigator |
NAKAJIMA Atsushi Yokohama City University, School of Medicine, Associate Prof., 大学院・医学研究科, 助教授 (30326037)
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| Co-Investigator(Kenkyū-buntansha) |
KIRIKOSHI Hiroyuki Yokohama City University, School of Medicine, Assistant, 医学部附属病院, 助手 (80347294)
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| Project Period (FY) |
2003 – 2004
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| Keywords | PPARγ / cre-lox / Fabp |
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| Research Abstract |
The purpose of this research is to clarify the role of PPARγ-intestinal disease, especially the association with colon cancer carcinogenesis and Inflammatory Bowel Disease. In this research, we made the conditional knockout mouse of PPARγ in intestine (using cre-lox system). The intestine specific promoter Fatty Acid Binding Protein (FABP) was used for cre-transgenic mouse, also we created the lox-PPAR transgenic mouse. We are now analyzing cre-lox-PPARγ conditional.
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Research Products
(9 results)
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[Journal Article] Efficacy of a Triple Therapy with Rabeprazole, Amoxicilin, and Faropenem as second-line Treatment after Failure of Initial Helicobacter pylori Eradication Therapy2005
Author(s)
Togawa J, Inamori M, Fujisawa N, Takahashi H, Yoneda M, Kawamura H, Abe Y, Kirikoshi H, Kobayashi N, Sakaguchi T, Takamura T, Nakajima A, Ueno N, Sekihara H
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Journal Title
Hepato-Gastroenterology 52
Pages: 645-648
Description
「研究成果報告書概要(和文)」より
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