2004 Fiscal Year Final Research Report Summary
Single nucleotide polymorphisms in interferon signaling pathway and immuno system response to interferon treatment in hepatitis C patients
| Project/Area Number |
15590710
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | National Hospital Organization Nagasaki Medical Center, Clinical Research Center |
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Principal Investigator |
YATSUHASHI Hiroshi National Hospital Organization Nagasaki Medical Center, Clinical Research Center, Department of Therapeutic Research, Director, 長崎医療センター・臨床研究センター, 治療研究部長 (50360855)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Minoru National Hospital Organization Nagasaki Medical Center, Clinical Research Center, Department of Advanced Medical Research, Director, 長崎医療センター・臨床研究センター, 先端技術研究部長 (40217906)
YANO Koji National Hospital Organization Nagasaki Medical Center, Clinical Research Center, Division of International Medical Cooperation, Department of Medical Policy Project, Division Chief, 長崎医療センター・臨床研究センター, 政策医療企画研究部国際医療協力室長 (60360856)
FUJIOKA Hikaru National Hospital Organization Nagasaki Medical Center, Clinical Research Center, Department of Medical Morphology, Director, 長崎医療センター・臨床研究センター, 形態研究部長 (00264226)
ISHIBASHI Hiromi National Hospital Organization Nagasaki Medical Center, Clinical Research Center, Director General, 長崎医療センター・臨床研究センター, 臨床研究センター長 (80127969)
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| Project Period (FY) |
2003 – 2004
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| Keywords | Chronic Hepatitis C / IFN Signal / IFN Management / IFN Receptor |
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| Research Abstract |
Interferon alfa(IFN-alpha) therapy remains a mainstay of treatment in chronic hepatitis C. However, sustained viral response rates(SVR) remain low, and the search for factors important for response to therapy continues. Our study aimed to identify the host single nucleotide polymorphisms(SNPs) that predict IFN response in hepatitis C patients. We selected 16 genes (IFN-AR1, IFN-AR2, JAK1, TYK2, JAB(CIS), STAT1, STAT2, ISGF3G(IRF9), IRF1, IRF2, TAP1, TAP2, LMP7, PKR, MxA, IL-10) in the IFN signaling pathway involved in antiviral and signaling activities and immunity system. 269 SNPs for each of our 120(SVR : n=65 vs Non-SVR : n=55) patients were determined by invader assay. Statistical analysis identified 3 SNPs (IRF2-111 : OR 2.6 : P<0.01, MxA-200 : OR2.6 : P<0.02, IFNAR1-369 : OR3.4 : P<0.05) and Haplo type (IRF2-111/115 : T/G vs others : OR1.9 : P<0.03,C/A vs others : OR2.0 : P<0.04) statistically. In conclusion, this pilot identified SNPs as potential markers that could predict hepatitis C patient response.
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[Journal Article] A low-density cDNA microarray with a unique reference RNA : pattern recognition analysis for IFN efficacy prediction to HCV as a model2004
Author(s)
Daiba A, Inaba N, Ando S, Kajiyama N, Yatsuhashi H, Terasaki H, Ito A, Ogasawara M, Abe A, Yoshioka J, Hayashida K, Kaneko S, Kohara M, Ito S
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Journal Title
Biochem Biophys Res Commun 315・4
Pages: 1088-1096
Description
「研究成果報告書概要(和文)」より
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[Journal Article] A low-density cDNA microarray with a unique reference RNA : pattern recognition analysis for IFN efficacy prediction to HCV as a model.2004
Author(s)
Daiba A, Inaba N, Ando S, Kajiyama N, Yatsuhashi H, Terasaki H, Ito A, Ogasawara M, Abe A, Yoshioka J, Hayashida K, Kaneko S, Kohara M, Ito S.
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Journal Title
Biochem Biophys Res Commun 315(4)
Pages: 1088-1096
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Influence of Interleukin-10 Gene Promoter Polymorphisms on Disease Progression in Patients Chronically Infected With Hepatitis B Virus2002
Author(s)
S.Miyazoe, K.Hamasaki, K.Nakata, Y.Kajiya, K.Kitajima, K.Nakao, M.Daikoku, H.Yatsuhashi, M.Koga, M.Yano, K.Eguchi
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Journal Title
Am J Gastroenterol 97・8
Pages: 2086-2092
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Influence of Interleukin-10 Gene Promoter Polymorphisms on Disease Progression in Patients Chronically Infected With Hepatitis B Virus.2002
Author(s)
S.Miyazoe, K.Hamasaki, K.Nakata, Y.Kajiya, K.Kitajima, K.Nakao, M.Daikoku, H.Yatsuhashi, M.Koga, M.Yano, K.Eguchi
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Journal Title
Am J Gastroentero 197(8)
Pages: 2086-2092
Description
「研究成果報告書概要(欧文)」より
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