2004 Fiscal Year Final Research Report Summary
Influence of Serotonin Transporter Gene Polymorphism on Depressive Symptoms and New Cardiac Events after Acute Myocardial Infarction
| Project/Area Number |
15590743
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
SATO Hiroshi Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (10294092)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMURA Yasushi Osaka University, Graduate School of Medicine, Associate Professor, 医学部付属病院, 助教授 (90252642)
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| Project Period (FY) |
2003 – 2004
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| Keywords | acute myocardial infarction / depressive sympton / serotonin transporter / gene polymorphism / long-term prognosis |
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| Research Abstract |
To investigate whether the S allele was associated with depressive symptoms and cardiac events after AMI, we prospectively examined depressive symptoms and new cardiac events in 2,509 genotyped AMI patients.
Depressive symptoms were more common in patients with the S allele than in those without it (48.3% vs. 35.0%, P=0.02). Multivariate analysis revealed that the S allele was independently associated with depressive symptoms (odds ratio, 2.19; 95% CI, 1.21 to 3.98, P=0.01). Cardiac events (cardiac death, revascularization, heart failure, reinfarction, arrhythmia, and unstable angina) were more frequent in patients with the S allele than in those without it (31.3% vs. 22.3%, P=-0.046). Multivariate Cox regression analysis revealed an association between the S allele and increased risk of cardiac events (hazard ratio (HR), 1.69; 95% CI, 1.03 to 2.78; P=0.04). However, the HR became unsignificant after adjustment for depressive symptoms (HR; 1.30, 95% Ch 0.84 to 2.01, P=0.24).
The S allele in the 5-HTTLPR is associated with an increased risk of subsequent cardiac events which is mediated, at least in part, by the depressive symptoms in patients after AMI.
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Research Products
(19 results)
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[Journal Article] Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro.2004
Author(s)
Ozaki K, Inoue K, Sato H, Iida A, Ohnishi Y, Sekine A, Sato H, Odashiro K, Nobuyoshi M, Hori M, Nakamura Y, Tanaka T
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Journal Title
Nature. May6;429(6987)
Pages: 72-75
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Variation during the week in the incidence of acute myocardial infarction increased risk for Japanese women on Saturdays.2003
Author(s)
Kinjo K, Sato H, Sato H, Shiotani I, Kurotobi T, Ohnishi Y, Hishida E, Nakatani D, Mizuno H, Yamada Y, Fukui S, Fukunami M, Nanto S, Matsu-ura Y, Takeda H, Hori M ; Osaka Acute Coronary Insufficiency Study (OACIS) Group
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Journal Title
Heart. Apr; 89(4)
Pages: 398-403
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Impact of high sensitivity C-reactive protein on predicting long-term mortality of acute myocardial infarction.2003
Author(s)
Kinjo K, Sato H, Ohnishi Y, Hishida E, Nakatani D, Mizuno H, Imai K, Nanto S, Naka M, Matsumura Y, Takeda H, Hori M ; Osaka Acute Coronary Insufficiency Study (OACIS) Group
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Journal Title
Am J Cardiol. Apr15;91(8)
Pages: 931-935
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Prognostic significance of atrial fibrillation/atrial flutter in patients with acute myocardial infarction treated with percutaneous coronary intervention.2003
Author(s)
Kinjo K, Sato H, Sato H, Ohnishi Y, Hishida E, Nakatani D, Mizuno H, Fukunami M, Koretsune Y, Takeda H, Hori M ; Osaka Acute Coronary Insufficiency Study (OACIS) Group
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Journal Title
Am J Cardiol. Nov15;92(10)
Pages: 1150-1154
Description
「研究成果報告書概要(欧文)」より
