2004 Fiscal Year Final Research Report Summary
Role of Renin-Angiotensin system in the development of ischemic mitral regurgitation
| Project/Area Number |
15590760
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kagoshima University |
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Principal Investigator |
OTSUJI Yutaka Kagoshima University, University Hospital, Faculty of Medicine and Dentistry, Assistant Professor, 医学部・歯学部附属病院, 講師 (30264427)
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| Co-Investigator(Kenkyū-buntansha) |
BIRO Sadatoshi Kagoshima University, University Hospital, Faculty of Medicine and Dentistry, Assistant Professor, 医学部・歯学部附属病院, 講師 (50244231)
TEI Chuwa Kagoshima University, Graduate School of Medical and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (10163891)
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| Project Period (FY) |
2003 – 2004
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| Keywords | ischemic mitral regurgitation / Renin angiotensin / remodeling / congestive heart failure |
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| Research Abstract |
Ischemic mitral regurgitation (MR) is an independent factor to worsen patients prognosis after the development of acute myocardial infarction. Outward displacement of papillary muscles due to left ventricular remodeling is the main cause of the ischemic MR. Renin-Angiotensin system (RAS) plays a central role in the genesis of left ventricular remodeling following myocardial infarction. Therefore, activation of RAS system may play an essential role in the genesis of ischemic MR, however, the role of RAS on the development of ischemic MR remains uninvestigated.
We hypothesized that development of ischemic MR can be attenuated by the absence of RAS activation due to gene abnormality. We produced acute myocardial infarction (AMI) with a similar size by ligation of left anterior descending artery in wild mouse as well as in Angiotensin II type 1A knocked out mouse. The LV dilatation was significantly greater in the wild compared to knocked out mouse. Ischemic MR was observed only in wild mouse (p<0.05). These suggest that RAS plays a central role in the genesis of ischemic MR after the development of AMI.
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[Journal Article] Relation of aneurysmectomy in patients with advanced left ventricular remodeling to postoperative left ventricular filling pressure, redilatation with ischemic mitral regurgitation.2005
Author(s)
Otsuji Y, Kuwahara E, Yuge K, Yotsumoto G, Ueno T, Nakashiki K, Hamasaki S, Biro S, Minagoe S, Levine RA, Sakata R, Tei C
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Journal Title
Am J Cardiol 95(4)
Pages: 517-521
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Papillary muscle dysfunction attenuates ischemic mitral regurgitation in patients with localized basal inferior left ventricular remodeling : insights from tissue Doppler strain imaging.2005
Author(s)
Uemura T, Otsuji Y, Nakashiki K, Yoshifuku S, Maki Y, Yu B, Mizukami N, Kuwahara E, Hamasaki S, Biro S, Kisanuki A, Minagoe S, Levine RA, Tei C
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Journal Title
J Am Coll Cardiol 46(1)
Pages: 113-119
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Mechanism of persistent ischemic mitral regurgitation after annuloplasty : importance of augmented posterior mitral leaflet tethering.2005
Author(s)
Zhu F, Otsuji Y, Yotsumoto G, Yuasa T, Ueno T, Yu B, Koriyama C, Hamasaki S, Biro S, Kisanuki A, Minagoe S, Levine RA, Sakata R, Tei C
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Journal Title
Circulation 112(suppl 1)
Pages: 1-396-1-401
Description
「研究成果報告書概要(欧文)」より
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