2004 Fiscal Year Final Research Report Summary
A role of anandamide in the development of acute lung injury
| Project/Area Number |
15590801
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Shinshu University |
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Principal Investigator |
KOIZUMI Tomonobu Shinshu University, School of Medicine Hospital, Associate Professor, 医学部附属病院, 講師 (20273097)
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| Co-Investigator(Kenkyū-buntansha) |
KUBO Keishi Shinshu University, School of Medicine, Professor, 医学部, 教授 (80143965)
FUJIMOTO Keisaku Shinshu University, School of Medicine, Associate Professor, 医学部, 助教授 (70242691)
HANAOKA Masayuki Shinshu University, School of Medicine, Associate Professor, 医学部, 講師 (20334899)
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| Project Period (FY) |
2003 – 2004
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| Keywords | anadamide / endotoxin / lung injury / polymixin B / sheep |
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| Research Abstract |
We examined the role of anandamide in the acute lung injury in sheep. We prepared awake sheep with vascular monitoring and lung lymph balance. 5 mg of anandamide was infused intravenously after stable baseline over 2 hours. Pulmonary and systemic artery pressure, cardiac output and lung lymph flow were measured every 30 min. After the infusion of anandamide, there were no significant changes in these parameters. Based on the findings, anandmide seems to be independent in the pathophysiology in acute lung injury in sheep. It should be necessary to examine the dose response of anandmide.
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