2004 Fiscal Year Final Research Report Summary
Immunohistochemical study of cell cycle regulators in idiopathic pulmonary fibrosis
| Project/Area Number |
15590802
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
CHIDA Kingo Hamamatsu University School of Medicine, Second Division Department of Internal Medicine, Associate Professor, 医学部, 助教授 (40197611)
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| Co-Investigator(Kenkyū-buntansha) |
SUDA Takafui Hamamatsu University School of Medicine, Second Division Department of Internal Medicine, Assistant Professor, 医学部, 助手 (30291397)
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| Project Period (FY) |
2003 – 2004
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| Keywords | idiopathic pulmonary fibrosis / control of cell cycle / fibroblast |
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| Research Abstract |
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic disorder characterized by the proliferation of fibroblasts. Fibroblast proliferation in IPF is generally observed as a process following epithelial injury and alveolitis, but details of the mechanism remain to be clarified.
Cyclin dependent kinase (CDK) and the tumor suppressor gene, CDK inhibitor regulate cell cycle and are implicated in cell proliferation. On this basis, we hypothesized that fibroblasts in IPF have an abnormality of cell cycle regulating factors. In this report, we utilized immunohistochemistry to examine the level of expression of pRB(retinoblastoma gene product) and p27, both of which play central roles in a major tumor suppressive pathway (RB pathway), in surgically resected lung tissues of patients with IPF. The expression of pRB was reduced in fibroblastic foci compared with the adjacent tissues, while the expression of p27 did not vary. That results suggest that downregulation of pRB in fibroblastic foci contribute to the pathogenesis of IPF.
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[Journal Article] Nonspecific interstitial pneumonia in collagen vascular diseases : comparison of the clinical characteristics and prognostic significance with usual interstitial pneumonia.2003
Author(s)
Nakamura Y, Chida K, Suda T, Hayakawa H, Iwata M, Imokawa S, Tsuchiya T, Ida M, Gemma H, Yasuda K, Yagi T, Shirai T, Tamura R, Nakano Y, Hirata T, Nakamura H, Colby TV
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Journal Title
Sarcoidosis Vasc Diffuse Lung Dis 20(3)
Pages: 235-241
Description
「研究成果報告書概要(欧文)」より
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