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2004 Fiscal Year Final Research Report Summary

Assessment of specific cognitive function of the striatum in a primate model of Parkinson's disease.

Research Project

Project/Area Number 15590904
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionJICHI MEDICAL SCHOOL

Principal Investigator

MURAMATSU Shin-ichi  Jichi Medical School, Medicine, Associate Professor, 医学部, 助教授 (10239543)

Project Period (FY) 2003 – 2004
Keywordsbasal ganglia / dopamine / Parkinson's disease / gene therapy / cognitive function / MPTP / cynomolgus monkey / adeno-associated virus
Research Abstract

To elucidate the cognitive function specific to the striatum, groups of cynomolgus monkeys with toxin-induced Parkinsonian motor symptoms were compared with normal controls on a computerized battery of tests designed to investigate conception set shift. The tests assess the ability to shift cognitive set modeled after the Wisconsin Card Sorting Test that is sensitive to impairments in patients with Parkinson's disease(PD). The monkeys with chronic treatment of 1-metil-4-phenil-1-2-3-6-tetrahydropyridine (MPTP) showed similar difficulty with the patients with PD in the set-shift task. Positron emission tomography showed that impairment of dopaminergic function was confined to the nigro-striatal system in these monkeys and that recombinant adeno-associated viral vector (AAV)-mediated selective restoration of 1-dopa uptake in the treated putamen. The combination of computerized battery of tests and gene transfer using AAV vectors is a powerful tool to study higher cognitive function of the basal ganglia.

  • Research Products

    (17 results)

All 2005 2004 2003 Other

All Journal Article (15 results) Book (2 results)

  • [Journal Article] Unrestricetd hepatocyte transduction with AVV serotype 8 vectors in mice.2005

    • Author(s)
      Nakai, H.
    • Journal Title

      Journal of Virology 79・1

      Pages: 214-224

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Gene therapy for Parkinson's disease using recombinant adeno-associated viral vectors.2005

    • Author(s)
      Muramatsu, S.
    • Journal Title

      Expert Opinion on Biological Therapy 5・5

      Pages: 663-671

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Unrestricted hepatocyte transduction with AAV serotype 〜2005

    • Author(s)
      Nakai, H.
    • Journal Title

      Journal of Virology 79・1

      Pages: 214-224

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Gene therapy for Parkinson's disease using 〜2005

    • Author(s)
      Muramatsu, S.
    • Journal Title

      Expert Opinion on Biological Therapy 5・5

      Pages: 663-671

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 遺伝子治療2004

    • Author(s)
      村松 慎一
    • Journal Title

      日本臨床 62・9

      Pages: 1648-1652

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] パーキンソン病モデルサルへのES細胞由来神経幹細胞の移植2004

    • Author(s)
      村松 慎一
    • Journal Title

      日本再生医療学会雑誌 3

      Pages: 39-44

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Gene therapy for Parkinson's disease2004

    • Author(s)
      Muramatsu, S.
    • Journal Title

      Japanese Journal of Clinical Medicine 62・9

      Pages: 1648-1652

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Transplantation of neural stem cells derived from embryonic 〜2004

    • Author(s)
      Muramatsu, S.
    • Journal Title

      Regenerative Medecine 3

      Pages: 39-44

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Adeno-associated viral vectors for Parkinson's disease.2003

    • Author(s)
      Muramatsu, S.
    • Journal Title

      International Review of Neurobiology 55

      Pages: 205-222

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Efficient gene transfer of a simian immunodeficiency viral vector into cardiomyocytes derived from primate embryonic stem cells.2003

    • Author(s)
      Nagata, M.
    • Journal Title

      Journal of Gene Medicine 5・11

      Pages: 921-928

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Intramuscular injection of AAV-GDNF results in sustained expression of transgenic GDNF, and its delivery to spinal motoneurons by retrograde transport.2003

    • Author(s)
      Lu, Y.Y.
    • Journal Title

      Neurosci Res 45・1

      Pages: 33-40

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Intramuscular injection of AAV-GDNF results in 〜2003

    • Author(s)
      Lu, Y.Y.
    • Journal Title

      Neurosci Res 45・1

      Pages: 33-40

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Efficient gene transfer of a simian immunodeficiency 〜2003

    • Author(s)
      Nagata, M.
    • Journal Title

      Journal of Gene Medicine 5・11

      Pages: 921-928

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Specific and efficient transduction of cochlear inner hair cells with recombinant adeno-associated virus type 3 vector.

    • Author(s)
      Liu, Y.
    • Journal Title

      Molecular Therapy (In press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Specific and efficient transduction of cochlear inner hair 〜

    • Author(s)
      Liu Y.
    • Journal Title

      Molecular Therapy (In press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Progress in gene therapy.2003

    • Author(s)
      Muramatsu, S. et al.
    • Publisher
      VSP
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Progress in gene therapy.2003

    • Author(s)
      Muramatsu, S.
    • Publisher
      VSP
    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2006-07-11  

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