Comparative clinico-molecular pathological study of corticobasal degeneration and progressive supranuclear palsy

2004 Fiscal Year Final Research Report Summary

• Project/Area Number: 15590913
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Nippon Medical School
• Principal Investigator: YAMAZAKI Mineo Nippon Medical School, teaching fellow, 医学部, 助手 (10277577)
• Co-Investigator(Kenkyū-buntansha): MURAYAMA Shigeo Tokyo Metropolitan Institute of Gerontology, Team Leader, 老化臨床神経科学研究グループ, 参事研究員 (50183653)
• Project Period (FY): 2003 – 2004
• Keywords: corticobasal degeneration / progressive supranuclear palsy / tauopathy

Research Abstract

Progressive supranuclear palsy(PSP) is a neurodegenerative disorder that is characterized by parkinsonism and dementia. However, the aged patients with PSP did not always show both parkinsonism and dementia. We investigated retrospectively the clinical data of 51 autopsy-proven cases with PSP to clarify their clinicopathological multiplicity. Among 51 patients with PSP,21 cases showed typical neurological symptoms compatible to PSP, but 20 cases did not show apparent parkinsonism and could go about their daily life without any problem. Among 20 PSP patients lacking obvious parkinsonism,14 cases presented only dementia (mean age:85.5±7.5) and six cases did not show obvious parkinsonism nor dementia (mean age:90.5±9.8). The mean age of PSP cases without parkinsonism was significantly higher than that of PSP cases with parkinsonism. But there is no significant difference in the brain weight of PSP patients between those with and without parkinsonism. Only two cases with PSP showed cerebellar ataxia, but the distribution and severity of lesions were same as those of other PSP cases. Parts pf the aged PSP patients, though a few in number, showed only dementia.

Research Products

• [Journal Article] Midbrain hypometabolisim as an early diagnostic sign for progressive supranuclear palsy (2004)
  • Author(s): Mishina M, Ishii K, Mitani K, Yamazaki M, 他5名, Katayama Y
  • Journal Title: Acta Neurol Scand 110 Pages: 128-133
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A clinical and genetic study in a large cohort of patients with spinocerebellar ataxia type 6 (2004)
  • Author(s): Takahashi H, Ishikawa K, 他15名, Yamazaki M, Mizusawa H
  • Journal Title: J Human Genetics 49 Pages: 256-264
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 血管性痴呆-危険因子・画像・病理 (2004)
  • Author(s): 山崎峰雄, 片山泰朗
  • Journal Title: 分子脳血管病 3 Pages: 376-382
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Neuropathological diagnostic criteria for Alzheimer's disease. (2004)
  • Author(s): Murayama S, Saito Y.
  • Journal Title: Neuropathology 24 Pages: 254-260
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A pre-senile case of limbic encephalitis and cerebellar degeneration, with subacute onset of progressive dementia (2004)
  • Author(s): Mori O, Yamazaki M, Yamazaki M他4名
  • Journal Title: J Nippon Med Sch. 71 Pages: 412-416
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Midbrain hypometabolisim as an early diagnostic sign for progressive supranuclear palsy (2004)
  • Author(s): M.Mishina, K.Ishii, K.Mitani, M.Ohyama, M.Yamazaki, K.Ishiwata, M.Senda, S.Kobayashi, S.Kitamura, Y.Katayama
  • Journal Title: Acta Neurol Scand 110(2) Pages: 128-133
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A pre-senile case of limbic encephalitis and cerebellar degeneration, with subacute onset of progressive dementia. (2004)
  • Author(s): Mori O, Yamazaki M, Yamazaki M, Komiyama T, Ohaki Y, Katayama Y, Naito Z
  • Journal Title: J Nippon Med Sch. 71 Pages: 412-416
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A clinical and genetic study in a large cohort of patients with spinocerebellar ataxia type 6 (2004)
  • Author(s): Hiroki Takahashi, Kinya Ishikawa, Takeshi Tsutsumi, Hiroto Fujigasaki, Akihiro Kawada, Ryoichi Okiyama, Tsuneo Fujita, Kazuo Yoshizawa, Yoshinori Yamaguchi, Hitoshi Timiyasu, Fumihito Yoshii, Kazuko Mitani, Natsue Shimizu, Mineo Yamazaki, Tomoyuki Miyamoto, Tomoyuki Orimo, Shin'ichi Shoji, Ken Kitamura, Hidehiro Mizusawa
  • Journal Title: J Human Genetics 49 Pages: 256-264
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neuropathological diagnostic criteria for Alzheimer's disease. (2004)
  • Author(s): Shigeo Murayama, Yuko Saito
  • Journal Title: Neuropathology 24 Pages: 254-260
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Amyotrophic lateral sclerosis : On the origin of the degenerated fibers in the white matter of the spinal cord.
  • Author(s): Kiyomitsu Oyanagi, Mineo Yamazaki, Emiko Kawakami, Takashi Morita, Takao Makifuchi, Hitoshi Takahashi
  • Journal Title: Amyotrophic Lateral Sclerosis : New Research(Editors : Murray, Christine A.)(Nova Science Publishers) (In press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] Amyotrophic Lateral Sclerosis : New Research. "Amyotrophic Lateral Sclerosis : On the Origin of the Degenerated Fibers in the White Matter of the Spinal Cord
  • Author(s): K.Oyanagi, M.Yamazaki et al.
  • Publisher: Nova Science Publishers(印刷中)
  • Description: 「研究成果報告書概要(和文)」より