2004 Fiscal Year Final Research Report Summary
Mechanism of Vascular Calcification : Role of Calcium and Phosphate Metabolism
| Project/Area Number |
15590954
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Osaka City University |
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Principal Investigator |
JONO Shuichi Osaka City University, Graduate School of Medicine, Department of Metabolism, Endocrinology and Molecular Medicine, Research Associate, 大学院・医学研究科, 助手 (60336790)
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| Co-Investigator(Kenkyū-buntansha) |
SHIOI Atsushi Osaka City University, Graduate School of Medicine, Department of Cardiovascular Medicine, Lecturer, 大学院・医学研究科, 講師 (90260801)
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| Project Period (FY) |
2003 – 2004
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| Keywords | Vascular calcification / Atherosclerosis / Osteoprotegerin / Matrix Gla protein / Phosphate transporter / Bone associated protein |
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| Research Abstract |
Vascular calcification is often encountered in the development of atherosclerotic intimal lesions. In chronic renal failure patients, vascular calcification contributes to both the morbidity and mortality. Although the molecular mechanisms regulating vascular calcification remain obscure, recent studies suggest that vascular calcification may be an actively regulated process in which vascular cells may acquire osteoblast-like functions. Several clinical studies indicate that a high serum phosphate level is highly correlated with the extent of vascular calcification and vascular disease. In vitro studies demonstrated that inorganic phosphate regulates the expression of bone matrix proteins, and that calcification is regulated by inorganic phosphate through a sodium dependent phosphate transport system. These findings suggest that inorganic phosphate may play an important role in the development of vascular calcification.
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[Book] 腎不全とリン2004
Author(s)
城野修一
Total Pages
197
Publisher
日本メデイカルセンター
Description
「研究成果報告書概要(和文)」より
