• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2005 Fiscal Year Final Research Report Summary

Thrifty genotype and thrifty phenotype in children with diabetes and/or obesity

Research Project

Project/Area Number 15591131
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionKitasato University

Principal Investigator

YOKOTA Yukifumi  Kitasato University, School of Medicine, assistant professor, 医学部, 講師 (40158366)

Co-Investigator(Kenkyū-buntansha) NOWATARI Masahiko  Kitasato University, School of Medicine, assistant professor, 医学部, 講師 (00208406)
MATSUURA Nobuo  Seitoku University, Faculty of Humanities, professor, 人文学部, 教授 (50002332)
Project Period (FY) 2003 – 2005
KeywordsDiabetes Mellitus / type 1 diabetes mellitus / Puberty / leptin / adiponectin / thrifty genotype
Research Abstract

Little evidence is available regarding serum adiponectin, leptin and its relationship with glycemic control and obesity-related gene polymorphisms in childhood-onset TIDM. Blood was sampled from twenty four T1 diabetic pubertal girls (mean age : 15.9) once a year for more than three years serially. Obesity-related gene polymorphisms including uncoupling protein-1 gene (UCP1, A3826G), β3-adrenergic receptor gene (β3AR, Trp64Arg) and adiponectin gene (SNP45, 164, 276, 349) were determined by PCR direct sequences. We investigated the relationships between serum adipocytokine levels, obesity-related gene polymorphisms, glycemic control (HbA1C), daily insulin dosage, BMI and blood pressure. Serum adiponectin levels (mean : 9.60±4.64μg/ml) were negatively related with age (p=0.0025), BMI (p<0.001), systolic blood pressure (p=0.015). Serum leptin levels (mean : 16.6±11.6ng/ml) were positively related with age (p<0.001), BMI (p<0.001), systolic blood pressure (p<0.001), insulin dosage (p<0.001). No significant correlation was found between serum adiponectin/leptin levels and HbA1C. The results of gene analysis for polymorphisms were as follows : UCP1(n=24) ; A/G(15), G/G(3), A/A(6), β3AR ; T/T(17), T/A(5), A/A(2), AdipoSNP45 ; T/T(7), T/G(15), G/G(2), SNP276 ; G/G(18), T/G(6), SNP349 ; A/A(10), A/G(12), G/G(2), SNP164 ; I/I(23), I/T(1). The patients who had following gene polymorphisms (A/A and A/G in UCP1, T/T in β3AR, T/T in AdipoSNP45, A/A in AdipoSNP349) showed hyperleptinemia and hypoadiponectinemia. One patient who had a adiponectin gene SNP 164I/T showed extremely low mean serum adiponectin level (3.4±1.4μg/ml). In pubertal girls with T1DM, obesity related dysadipocytokinemia appeared and life-style intervention with weight control based on obesity-related gene polymorphisms will be important.

  • Research Products

    (10 results)

All 2006 2005

All Journal Article (10 results)

  • [Journal Article] The associations of the specific HLA-DRB, HLA-DQA, and HLA-DQB alleles and haplotypes with type 1 diabetes in Japanese children2006

    • Author(s)
      Noriyuki Takubo
    • Journal Title

      The Kitasato Medical Journal 34(2)

      Pages: 76-82

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The associations of the specific HLA-DRB, HLA-DQA, and HLA-DQB alleles and haplotypes with type 1 diabetes in Japanese children2006

    • Author(s)
      Noriyuki Takubo, Shigeyuki Ootsu, Keiko Nomoto, Mayumi Kazahari, Yukifumi Yokota, Nobuo Matsuura
    • Journal Title

      The Kitasato Medical Journal 34(2)

      Pages: 76-82

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Assays for Thyroid-stimulating Antibodies and Thyrotropin-binding Inhibitory Immunoglobulins in Children with Graves' Disease2005

    • Author(s)
      Keiko Shibayama
    • Journal Title

      Endocrine Journal 52(5)

      Pages: 505-510

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Slowly progressing form of type 1 diabetes mellitus in children : genetic analysis compared with other forms of diabetes mellitus in Japanese children2005

    • Author(s)
      Shigeyuki Ohtsu
    • Journal Title

      Pediatric Diabetes 6(4)

      Pages: 221-229

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 小児副腎皮質機能低下症でのハイドロコーチゾン坐剤の有用性2005

    • Author(s)
      横田行史
    • Journal Title

      日本内分泌学会雑誌第15回臨床内分泌代謝Update Proceeding 81(Suppl.)

      Pages: 98-100

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] そこが知りたい性の問題 思春期遅発の病態、鑑別、検査の進め方は?2005

    • Author(s)
      横田行史
    • Journal Title

      小児内科 37(8)

      Pages: 1069-1073

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Assays for Thyroid-stimulating Antibodies and Thyrotropin-binding Inhibitory Immunoglobulins in Children with Graves' Disease2005

    • Author(s)
      Keiko Shibayama, Yoshihide Ohyama, Yukifumi Yokota, Shigeyuki Ohtsy, Noriyuki Takubo, Nobuo Matsuura
    • Journal Title

      Endocrine Journal 52(5)

      Pages: 505-510

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Slowly progressing form of type 1 diabetes mellitus in children : genetic analysis compared with other forms of diabetes mellitus in Japanese children2005

    • Author(s)
      Shigeyuki Ohtsu, Noriyuki Takubo, Mayumi Kazahari, Keiko Nomoto, Fumiyuki Yokota, Nobuyuki Kikuchi, Akemi Koike, Nobuo Matsuura
    • Journal Title

      Pediatric Diabetes 6(4)

      Pages: 221-229

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Usefulness of hydrocortisone suppository in-children with adrenal insufficiency2005

    • Author(s)
      Yukifumi Yokota, Shigeyuki Ohtsu, Noriyuki Takubo, Mariko Shimohama, Mayumi Kazahari, Nobuo Matsuura.
    • Journal Title

      Japanese Journal of Endocrinology. 81(supple)

      Pages: 98-100

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Delayed puberty : pathophysiology and differential diagnosis2005

    • Author(s)
      Yukifumi Yokota.
    • Journal Title

      Japanese Journal of Pediatric Medicine. 37(8)

      Pages: 1069-1073

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2007-12-13  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi