Research on receptor of varicella-zoster virus

2005 Fiscal Year Final Research Report Summary

• Project/Area Number: 15591147
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Kawasaki Medical School
• Principal Investigator: TERADA Kihei Kawasaki Medical School, Medicine, Associated Professor, 医学部, 助教授 (50172094)
• Co-Investigator(Kenkyū-buntansha): NIIZUMA Takahiro Kawasaki Medical School, Medicine, Assistant Professor, 医学部, 講師 (70351898) ; OGITA Satoko Kawasaki Medical School, Medicine, Assistant Professor, 医学部, 講師 (40309555)
• Project Period (FY): 2003 – 2005
• Keywords: Varicella-zoster virus / Cell tropism / Natural Killer

Research Abstract

Cell tropism of varicella-zoster virus (VZV) Oka strain was investigated for the pathogenesis by the in vitro infection of peripheral blood mononuclear cells (PBMCs) obtained from healthy adults. After a short incubation of VZV and PBMCs,VZV DNA was quantified in sorted subsets of T cells of CD3,CD4 and CD45RO,B cells of CD19,CD20,CD21,CD22 and CD74, and NK cells of CD16,CD56 and CD57 using a real-time PCR assay. The copy numbers were relatively large in a part of NK and B cells. In the comparison between the positive and negative cells, NK cells of CD56 positive adsorbed VZV significantly more than did the negative cells (p=.008). This cell tropism may be one of mechanism of escaping from immunity to decrease the function in NK cells and may be associated with transient absence of NK cells in life threatening chickenpox which had been reported.

Research Products

• [Journal Article] Characteristics of facial nerve plasy during childhood in Japan. -Varicella zoster virus association. (2006)
  • Author(s): Ogita S, Terada K, et al.
  • Journal Title: Pediatr Internat 48 Pages: 245-249
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Characteristics of facial nerve plasy during childhood in Japan. (2006)
  • Author(s): Ogita S, Terada K, Niizuma T, Kosaka Y, Kataoka N.
  • Journal Title: Pediatr Int 48 Pages: 245-249
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Bilateral facial nerve palsy associated with Epstein-Barr virus infection with a review of the literature. (2004)
  • Author(s): Treada K, Niizuma N, Kosaka Y, Inoue M, Ogita S, Kataoka N.
  • Journal Title: Scand J Infect Dis 36 Pages: 75-77
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Elevated serum C-reactive protein. in mumps orchitis. (2004)
  • Author(s): Niizuma T, Terada K, Kosaka Y, Daimon Y, Inoue M, Ogita S, Kataoka N, Tanaka K.
  • Journal Title: Pediatr Infect Dis J 23 Pages: 971
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Review : Rubella and congenital rubella syndrome in Japan -epidemiologic problems- (2003)
  • Author(s): Kihei Terada
  • Journal Title: J J Infect Dis 56 Pages: 81-87
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Enhancement of immunity against VZV by giving live varicella vaccine to the elderly assessed by VZV skin test and IAHA, gpELISA antibody assay. (2003)
  • Author(s): Takahashi M, Okada S, Miyagawa H, Amo K, Yoshikawa K, Asada H, Kamiya H, Torigoe S, Asano Y, Ozaki T, Thrada K et al.
  • Journal Title: Vaccine 21 Pages: 3845-3853
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] 実践予防接種マニュアル (2005)
  • Author(s): 寺田喜平
  • Total Pages: 229
  • Publisher: 中外医学社
  • Description: 「研究成果報告書概要(和文)」より