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2004 Fiscal Year Final Research Report Summary

Genome-wide Association Study of Psoriasis Using Polymorphic Microsatellite Markers

Research Project

Project/Area Number 15591195
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionTokai University

Principal Investigator

UMEZAWA Yoshinori  Tokai University, School of Medicine, Assistant Professor, 医学部, 講師 (50276903)

Co-Investigator(Kenkyū-buntansha) OZAWA Akira  Tokai University, School of Medicine, Professor, 医学部, 教授 (20096209)
INOKO Hidetoshi  Tokai University, School of Medicine, Professor, 医学部, 教授 (10101932)
Project Period (FY) 2003 – 2004
Keywordspsoriasis / susceptibility gene / Polymorphic Microsatellite Markers
Research Abstract

Genome-wide studies of psoriasis has made remarkable progress recently. These studies have identified many psoriasis susceptibility loci on several chromosomes. However, psoriasis susceptibility genes have not identified. In this study, we have systematically performed association analysis of psoriasis to define all psoriasis susceptibility loci. The subjects investigated in this study were unrelated Japanese patients with psoriasis vulgaris. Independent 125 samples were pooled for the 1st, 2nd and 3rd sets. Similarly, independent 125 unrelated healthy individuals as controls were pooled for the 1st, 2nd and 3rd sets. We used the 1st set pooled DNA for the 1st screening. After that, 2nd and 3rd sets were used for the 2nd and 3rd screening to avoid false positive associations. As the result, putative psoriasis candidate loci were narrowed down to less than 40 regions.

  • Research Products

    (12 results)

All 2004 2003

All Journal Article (12 results)

  • [Journal Article] hRDH-E2 gene polymorphisms, variable, transcriptional start sites, and psoriasis2004

    • Author(s)
      Matsuzaka Yasunari, et al.
    • Journal Title

      Mamm Genome 15(8)

      Pages: 668-675

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 膿疱性乾癬,関節症性乾癬2004

    • Author(s)
      梅澤慶紀, 小澤 明
    • Journal Title

      皮膚科の臨床 46(10)

      Pages: 1556-1563

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] hRDH-E2 gene polymorphisms, variable transcriptional start sites, and psoriasis2004

    • Author(s)
      Matsuzaka Yasunari, et al.
    • Journal Title

      Mammalian Genome 15(8)

      Pages: 668-675

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Generalized Pustular Psoriasis and Psoriasis Arthropathica2004

    • Author(s)
      Yoshinori Umezawa, Akira Ozawa
    • Journal Title

      Rinsho derma (Tokyo) 46(10)

      Pages: 1556-1563

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 乾癬のシクロスポリン療法におけるTDM(Therapeutic Drug Monitoring)の検討-シクロスポリンMEPC製剤(ネオーナル^<【○!R】>)のモニタリング法について-2003

    • Author(s)
      梅澤慶紀ほか
    • Journal Title

      西日本皮膚科 65(2)

      Pages: 183-187

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 乾癬とその類症2003

    • Author(s)
      梅澤慶紀, 小澤 明
    • Journal Title

      小児科診療 66(増)

      Pages: 107-112

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Therapeutic guidelines for the treatment of generalized pustular psoriasis (GPP) based on a proposed classification of disease severity2003

    • Author(s)
      Y.Umezawa, et al.
    • Journal Title

      Archives of Dermatological Research 295(Suppl.1)

      Pages: S43-S54

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 乾癬の免疫抑制薬治療における薬物動態に基づいた治療法確立2003

    • Author(s)
      梅澤慶紀ほか
    • Journal Title

      今日の移植 16(6)

      Pages: 609-611

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Management of Cyclosporine Therapy Based on TDM (Therapeutic Drug Monitoring) for psoriasis2003

    • Author(s)
      Yoshinori Umezawa, et al.
    • Journal Title

      The Nishinihon Journal of Dermatology 65(2)

      Pages: 183-187

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Psoriasis and its similar disease2003

    • Author(s)
      Yoshinori Umezawa, Akira Ozawa
    • Journal Title

      The Journal of Pediatric Practice 66(Suppl)

      Pages: 107-112

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Therapeutic guidelines for the treatment of generalized pustular psoriasis (GPP) based on a proposed classification of disease severity2003

    • Author(s)
      Yoshinori Umezawa, et al.
    • Journal Title

      Archives of Dermatological Research 295(Suppl.1)

      Pages: S43-S54

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Establishment of cyclosporine therapy based on the pharmacokinetic for psoriasis2003

    • Author(s)
      Yoshinori Umezawa, et al.
    • Journal Title

      Transplantation Now 16(6)

      Pages: 609-611

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2006-07-11  

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