2005 Fiscal Year Final Research Report Summary
Brain imaging and apolipoprotein E polymorphorism in frontotemporal dementia and Alzheimer's disease
| Project/Area Number |
15591210
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Yamagata University |
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Principal Investigator |
KAWAKATSU Hinobu Yamagata University, Department of Psychiatry, Associate Professor, 医学部, 助教授 (00211178)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Hiroshi Yamagata University, Department of Psychiatry, Assistant Professor, 医学部, 講師 (00333956)
KOMATANI Akio Yamagata University, Department of Psychiatry, Assistant Professor, 医学部, 講師 (10107188)
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| Project Period (FY) |
2003 – 2005
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| Keywords | MRI / hippocampus / SPECT / Alzheimer's disease / frontotemporal dementia / Pick's disease / appolipoprotein E / semantic dementia |
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| Research Abstract |
Brain imaging and apolipoprotein E phenotypes were examined in frontotempral dementia (FTD) and Alzheimer's disease (AD). Multi-shot diffusion weighted MRI revealed that the width of subiculum was significantly decreased both in FTD and AD than in controls. The width of subiculum was smallest in semantic dementia (SD), a subtype of FTD. Voxel-based volumetry using MRI also showed significant atrophy of entorhinal cortex both in FTD and AD. The extent of atrophy was again the strongest in SD. Tc-99m-ECD-SPECT and statistical imaging analysis using easy Z-score imaging showed that frontal and anterior temporal hypoperfusion in Pick type of FTD. In SD, anterior temporal hypoperfusion was characteristic, but extension of hypoperfusion areas to posterior temporal and parietal regions were seen in some patients.
The frequency to have at least one apolipoprotein E (ApoE) episilon 4 allele was 13% in controls, 43% in AD and 38% in FTD. When we analyzed by subdivision, the frequency was the highest in late-onset AD (59%) and in SD (60%).
Severe hippocampal and medial temporal atrophy and high frequency of ApoE4 suggest ApoE espsilon 4 allele may influence the vulnerability of hippocampal formation not only in late-onset AD but also in SD.
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