2004 Fiscal Year Final Research Report Summary

The study on microglial activation by beta amyloid, peptides of Alzheimer's disease.

Research Project

Project/Area Number	15591230
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Psychiatric science
Research Institution	KYUSHU UNIVERSITY
Principal Investigator	MONJI Akira Kyushu University, University Hospital, Research Associate, 大学病院, 助手 (00294942)
Co-Investigator(Kenkyū-buntansha)	NAKANISHI Hiroshi Kyushu University, Graduate School of Dental Sciences, Professor, 大学院・歯学研究院, 教授 (20155774)
Project Period (FY)	2003 – 2004
Keywords	beta amyloid / microglia / Alzheimer / cytokine / free radical
Research Abstract	There is increasing evidence that inflammatory activation of microglia has pathogenic infuence on Alzheimer's disease(AD). According to in vitro studies, microglia activated by beta amyloid (Abeta) peptides have been reported to damage or kill neurons by the release of neirotoxic molecules such as tumor necrosis factor-alpha(TNF-alfa), nitric oxide, or reactive oxygen species. This study has demonstrated the two following results on microglial activation by the A beta peptides. 1.Abeta fbril formation is not necessarily required for microglial activation by the peptides. 2.PS(phosphatidylserine)-liposomes can inhibit microglial activation by the Abeta peptides and suppress the generation of TNF-alfa, nitric oxide, and reactive oxygen species from microglia.

(2 results)