2004 Fiscal Year Final Research Report Summary

ANXIETY STUDY BY USING HGF TRANSGENICMICE

Research Project

Project/Area Number	15591232
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Psychiatric science
Research Institution	OITA UNIVERSITY (2004) 大分医科大学 (2003)
Principal Investigator	AKIYOSHI Jotaro OITA UNIVERSITY, FACULTY OF MEDICINE, ASSOCIATE PROFESSOR, 医学部, 助教授 (00159344)
Co-Investigator(Kenkyū-buntansha)	ISOGAWA Koichi OITA UNIVERSITY, FACULTY OF MEDICINE, ASSISTANT PROFFESOR, 医学部, 講師 (10264334) TSUTSUMI Takashi OITA UNIVERSITY, FACULTY OF MEDICINE, RESEARCH ASSISTANT, 医学部, 助手 (60284791)
Project Period (FY)	2003 – 2004
Keywords	HGF / ANXIETY / TRANSJENICMICE
Research Abstract	BACKGROUND : Hepatocyte growth factor(HGF) has the capacity to selectively direct thalamocortical projections into an intermediate target, the pallidum, and eventually to their final cortical destination. HGF may have a role in the mediation of anxiety. Very little is known about other central behavioral effects of HGF. OBJECTIVE : Our aim was to determine what effect HGF has on anxiety in rats. METHODS : HGF was infused at a constant rate into cerebral lateral ventricles and its effect on anxiety in rats was monitored. RESULTS : In the elevated plus maze test and the black and white box test, HGF administration caused all indicators of anxiety to increase. No significant effect on general locomotor activity was seen. CONCLUSION : HGF infusion into the brain produces an anxiolytic effect.

(2 results)