Analysis of neural mechanism related to working memory based on multi-dipole estimation with high temporal resolution.

2004 Fiscal Year Final Research Report Summary

• Project/Area Number: 15591240
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Tokyo Metropolitan University of Health Sciences
• Principal Investigator: KIKUCHI Yoshiaki Tokyo Metropolitan University of Health Sciences, Faculty of Health Sciences, Professor, 保健科学部, 教授 (50134739)
• Project Period (FY): 2003 – 2004
• Keywords: magnetoencephalography / mental rotation / spatio-temporal activity / working memory / multi-dipole estimation / MEG

Research Abstract

There are many higher-order cognitive processes whose neural mechanisms are hard to study by using nonhuman primates. The mental rotation task is one of the best studied of these. We investigated the spatio-temporal brain activity underlying mental rotation of different kinds of stimuli by measuring the magnetoencephalogram of subjects performing two kinds of mental rotation tasks, based on multi-dipole estimation with high temporal resolution. Visual stimuli in one experiment consisted of hand shapes presented at various orientations, and those in the other consisted of a set of alphabetic characters and their mirror images presented at various orientations. All stimuli were presented in the left visual field. Activity associated with visual stimulus processing was estimated in the lateral occipital lobe, basal occipito-temporal area, and inferior temporal gyrus. Activities related to higher visual processing were differed between the two kinds of stimuli we used. For the hand shapes experiment, we found right inferior parietal lobule activity at 200-300 ms after the stimulus presentation. For the alphabetic characters, activity was found in the left superior temporal region at about 300 ms. Furthermore, activity related to mental stimulation in the inferior parietal lobule and premotor area were seen in the both experiments. In the experiments with hands, the premotor activity showed left-hemispheric dominance. However, in the experiments with alphabetic characters, the laterality of the premotor activity did not show left-hemispheric dominance. We inferred this difference was influenced by the subjects 'familiarity with the mental rotation of visual stimuli.

Research Products

• [Journal Article] Magnetoencephalographic measurement during two types of mental rotations of three-dimensional objects. (2005)
  • Author(s): Kawamichi, H., Kikuchi, Y., Ueno, S.
  • Journal Title: IEEE Transaction on Magnetics (to appear)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Magnetoencephalographic measurement during two types of mental rotations of three-dimensional objects. (2005)
  • Author(s): Kawamichi, H., Kikuchi, Y., Ueno, S.
  • Journal Title: Intermag 2005
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Magnetoencephalographic measurement during two types of mental rotations of three-dimensional objects (2005)
  • Author(s): Kawamichi, H., Kikuchi, Y., Ueno, S.
  • Journal Title: Intermag 2005
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Language-related brain function during word repetition in post-stroke aphasics. (2004)
  • Author(s): Abo, M., Kikuchi, Y., et al.
  • Journal Title: NeuroReport 15 Pages: 1891-1894
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Spatio-temporal brain activity in mental rotation. (2004)
  • Author(s): Kawamichi, H., Kikuchi, Y., Ueno, S., Yoshizawa, S.
  • Journal Title: Neurology and Clinical Neurophysiology 66 Pages: 1-7
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Saptio-temporal activity in mental rotation of alphabetical character. (2004)
  • Author(s): Kawamichi, H., Kikuchi, Y., Ueno, S., Yoshizawa, S.
  • Journal Title: Proceedings of the 14^<th> International Conference on Biomagnetism Pages: 431-432
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Language-related brain function during word repetition in post-stroke aphasics (2004)
  • Author(s): Abo, M., Senoo, A., Watanabe, S., Miyano, S., Doseki, K., Sasaki, N, Kobayashi, K., Kikuchi, Y., Yonemoto, K.
  • Journal Title: Neuroreport 15 Pages: 1891-1894
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Reorganization and Neuromudulation during word repetition in poststroke aphasics (2004)
  • Author(s): Abo, M., Senoo, A., Yonemoto, K., Watanabe, S., Kikuchi, Y., Miyano, S.
  • Journal Title: 14^<th> European Congress of Physical and Rehabilitation Medicine. Vienna, Austria, May 12-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Traumatic brain injury rehabilitation in Japan: current and future challenges (2004)
  • Author(s): Watanabe, S., Yonemoto, K., Kikuchi, Y., Ohashi, M., Hashimoto, M., Abo, M., Miyano, M., Tanaka, M.
  • Journal Title: 14^<th> European Congress of Physical and Rehabilitation Medicine. Vienna, Austria, May 12-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Nonparametric regression analysis of functional brain images. (2003)
  • Author(s): Tsukimoto, H., Kakimoto, M., Morita, C., Kikuchi, Y.
  • Journal Title: Systems and Computers in Japan 35 Pages: 67-78
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Nonparametric regression analysis of functional brain images (2003)
  • Author(s): Tsukimoto, H., Kakimoto, M., Morita, C., Kikuchi, Y.
  • Journal Title: Systems and Computers in Japan Vol.35 Pages: 67-78
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Spatio-temporal activity in mental rotation of alphabetical character (1994)
  • Author(s): Kawamichi, H., Kikuchi, Y., Ueno, S., Yoshizawa, S.
  • Journal Title: Biomag 2004, (Edit by Halgren, E., Ahlfors, S.) Pages: 431-432
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Magnetoencephalographic measurement during two types of mental rotations of three-dimensional objects
  • Author(s): Kawamichi, H., Kikuchi, Y., Ueno, S.
  • Journal Title: IEEE Transaction on Magnetics (in print)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Spatio-temporal brain activity in mental rotation
  • Author(s): Kawamichi, H., Kikuchi, Y., Ueno, S., Yoshizawa, S.
  • Journal Title: Neurology and Clinical Neurophysiology.
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] An fMRI study on neural activity for eyes and the resemblance
  • Author(s): Tanaka, M., Kikuchi, Y., Senoo, A., Sato, T., Mori, T., Watanabe, S., Abo, M., Yonemoto, K.
  • Journal Title: Proceedings of 14^<th> European Congress of Physical and Rehabilitation Medicine
  • Description: 「研究成果報告書概要(欧文)」より