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2004 Fiscal Year Final Research Report Summary

Correction of partial volume effect in SPECT/PET using anatomical information

Research Project

Project/Area Number 15591273
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionOsaka University

Principal Investigator

MURASE Kenya  Osaka University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (50157773)

Co-Investigator(Kenkyū-buntansha) HATAZAWA Jun  Osaka University, Graduate School of Medicine, professor, 大学院・医学系研究科, 教授 (70198745)
OKU Naohiko  Osaka University, Hospital, Lecturer, 医学部附属病院, 講師 (40346193)
INOUE Osamu  Osaka University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (50159969)
TAMURA Shinichi  Osaka University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (30029540)
Project Period (FY) 2003 – 2004
KeywordsSPECT / PET / partial volume effect / anatomical information / Bayesian image reconstruction method / MRI / fuzzy clustering / Tc-99m HMPAO
Research Abstract

To accurately and quantitatively measure the distribution of radioisotope in the body using single photon emission computed tomography (SPECT) or positron emission tomography (PET), it is important to accurately correct for the partial volume effect (PVE). However, the correction of PVE is more difficult than that of attenuation and/or scattering in the body. On the other hand, it is possible to extract the anatomical information of the body from magnetic resonance imaging (MRI) using the segmentation method such as fuzzy clustering. Then, it is expected that if the anatomical information extracted from MRI can be introduced as a prior knowledge in the Bayesian image reconstruction method, it becomes possible to correct for PVE in SPECT or PET. Therefore, the purpose of this study was to develop a method for correcting for PVE in SPECT or PET by introducing the anatomical information extracted from MRI in the Bayesian image reconstruction method.
In 2003, we developed a software that introduces the anatomical information extracted from MRI as a prior knowledge in the Bayesian image reconstruction method. In 2004, we continued to develop the above software, and simultaneously started to evaluate the usefulness of this method using phantom experiments and clinical data. We obtained the preliminary results that encouraged the possibility of correcting for PVE using the above method.
In conclusion, this method appears to be useful for correcting for PVE in SPECT or PET. However, further studies are necessary to establish the usefulness of this method, and these studies are currently in progress.

  • Research Products

    (15 results)

All 2004 2003

All Journal Article (14 results) Book (1 results)

  • [Journal Article] Heterogeneity of cerebral blood flow in frontotemporal lobar degeneration and Alzheimer's disease2004

    • Author(s)
      Nagao M, Sugawara Y, Fukuhara R, Murase K
    • Journal Title

      Eur J Nucl Med Mol Imaging 31・2

      Pages: 162-168

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Extraction of arterial input function for measurement of brain perfusion index with ^<99m>Tc compounds2004

    • Author(s)
      Murase K, Nagayoshi M, Uenishi Y, Kawamata M
    • Journal Title

      Nucl Med Commun 25・3

      Pages: 299-303

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Truncation correction of fan beam transmission data for attenuation correction using parallel beam2004

    • Author(s)
      Takahashi Y, Murase K, Mochizuki T, Higashino H
    • Journal Title

      Nucl Med Commun 25・6

      Pages: 623-630

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Efficient method of calculating kinetic parameters using T1-weighted dynamic contrast2004

    • Author(s)
      Murase K
    • Journal Title

      Magn Reson Med 51・4

      Pages: 858-862

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Segmented attenuation correction for myocardial SPECT2004

    • Author(s)
      Takahashi Y, Murase K, Mochizuki T, Higashino H
    • Journal Title

      Ann Nucl Med 18・2

      Pages: 137-143

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Superimposed display of coronary artery on gated myocardial perfusion scintigraphy2004

    • Author(s)
      Nishimura Y, Fukuchi K, Katafuchi T, Murase K
    • Journal Title

      J Nucl Med 45・9

      Pages: 1444-1449

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Heterogeneity of cerebral blood flow in frontotemporal lobar degeneration and Alzheimer's disease2004

    • Author(s)
      Nagao M, Sugawara Y, Ikeda M, Fukuhara R, Hokoishi K, Murase K, Mochizuki T, Miki H, Kikuchi T.
    • Journal Title

      Eur J Nucl Med Mol Imaging 31-2

      Pages: 162-168

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Extraction of arterial input function for measurement of brain perfusion index with ^<99m>Tc compounds using fuzzy clustering2004

    • Author(s)
      Murase K, Nagayoshi M, Uenishi Y, Kawamata M, Yamazaki Y, Takasawa M, Oku N, Hatazawa J.
    • Journal Title

      Nucl Med Commun 25-3

      Pages: 299-303

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Truncation correction of fan beam transmission data for attenuation correction using parallel beam emission data on a 3-detector SPECT system2004

    • Author(s)
      Takahashi Y, Murase K, Mochizuki T, Higashino H, Motomura N.
    • Journal Title

      Nucl Med Commun 25-6

      Pages: 623-630

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Efficient method for calculating kinetic parameters using T1-weighted dynamic contrast-enhanced magnetic resonance imaging2004

    • Author(s)
      Murase K.
    • Journal Title

      Magn Reson Med 51-4

      Pages: 858-862

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Segmented attenuation correction for myocardial SPECT2004

    • Author(s)
      Takahashi Y, Murase K, Mochizuki T, Higashino H, Sugawara Y, Kinda A.
    • Journal Title

      Ann Nucl Med 18-2

      Pages: 137-143

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Superimposed display of coronary artery on gated myocardial perfusion scintigraphy2004

    • Author(s)
      Nishimura Y, Fukuchi K, Katafuchi T, Sagou M, Oka H, Ishida Y, Murase K.
    • Journal Title

      J Nucl Med 45-9

      Pages: 1444-1449

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Spectral analysis of ^<99m>Tc-HMPAO for estimating cerebral blood flow : a comparison with H_2^<15>O PET2004

    • Author(s)
      Takasawa M, Murase K, Oku N, Kawamata M, Nagayoshi M, Imaizumi M, Yoshikawa T, Osaki Y, Kimura Y, Kajimoto K, Kitagawa K, Hori M, Hatazawa J.
    • Journal Title

      Ann Nucl Med 18-3

      Pages: 243-249

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Evaluation of the number of SPECT projections in the ordered subsets-expectation maximization image reconstruction method2003

    • Author(s)
      Takahashi Y, Murase K, Mochizuki T, Higashino H, Sugawara Y, Kinda A.
    • Journal Title

      Ann Nucl Med 17-7

      Pages: 525-530

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 新・医用放射線技術実験2004

    • Author(s)
      村瀬 研也
    • Total Pages
      320
    • Publisher
      共立出版
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2006-07-11  

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