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2004 Fiscal Year Final Research Report Summary

Development and evaluation of limitation including error and reproducibility on assessment method of cerebral function using MRI

Research Project

Project/Area Number 15591280
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionThe University of Tokushima

Principal Investigator

HARADA Masafumi  The University of Tokushima, Radiologic Technology, Professor, 医学部, 教授 (20228654)

Co-Investigator(Kenkyū-buntansha) NISHITANI Hiromu  The University of Tokushima, Radiology, Professor, 大学院・ヘルスバイオサイエンス研究部, 教授 (50117206)
UNO Masaaki  The University of Tokushima, Neurosurgery, Lecturer, 大学院・ヘルスバイオサイエンス研究部, 講師 (90232884)
AKUTAGAWA Masatake  The University of Tokushima, Electronic Engineering, Lecturer, 工学部, 講師 (90294727)
MORI Kenji  The University of Tokushima, Pediatrics, Lecturer, 大学院・ヘルスバイオサイエンス研究部, 講師 (20274201)
SUMITANI Satsuki  The University of Tokushima, Psychiatry, Research Associate, 大学院・ヘルスバイオサイエンス研究部, 助手 (90346594)
Project Period (FY) 2003 – 2004
KeywordsFAIR / Proton MRS / 3T MRI / Perfusion / Metabolism / Glutamate / GABA / LCModel
Research Abstract

The purpose of this study is to evaluate the possibility and problem including error and reproducibility on the perfusion MRI and proton MR spectroscopy (proton MRS).
On perfusion MRI, flow sensitive alternating inversion recovery (FAIR) sequence was made and installed into our clinical MRI instrument. The different inversion times on FAIR were selected and compared with the cerebral blood perfusion using SPECT. The signal ratio (SR16/8) of two images with different TIs (1600ms and 800ms) was calculated and the cerebral blood flow reserve (CFR) was evaluated by the increase in the ratio of cerebral perfusion after administration of acetazolamide in the SPECT study. A reversed linear correlation (r=0.75) was found between SR and CFR, indicating that differences of FAIR images with changes of TI will be affected by cerebral flow reserve.
On proton MRS, the accuracy after curve-fitting of frequency domain data was increased by high magnetic field instrument at 3 Tesla, and the error was limited under 10%. The peak of glutamate and glutamine complex was also evaluated and the concentration of glutamate alone could be quantified with LCModel analysis on 3T MRS data. The value of SD of Glx by LCModel was under 15% and that of glutamate was under 25%.
Furthermore, the sequence of MEGA-PRESS was made into 3 Tesla MRI with frequency selective 180° pulses to detect peak of gamma amino-butyric acid (GABA). By this sequence, GABA was separated from other major metabolites at 3.01 ppm and the concentration of GABA was quantified with LCModel. The SD value of GABA was under 25% and its quantified value was agreed with the literature value.
The results indicates the new parameter of cerebral perfusion and the improvement of accuracy and reproducibility on proton MRS by high magnetic field at 3 Tesla.

  • Research Products

    (6 results)

All 2005 2004

All Journal Article (6 results)

  • [Journal Article] Elevation of plasma oxidized LDL in acute stroke patients is associated with predictive of infarct enlargement2005

    • Author(s)
      M.Uno, M.Harada, et al.
    • Journal Title

      Neurological Research 27巻

      Pages: 94-102

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Elevation of plasma oxidized LDL in acute stroke patients is associated with predictive of infarct enlargement2005

    • Author(s)
      Masaaki Uno, et al.
    • Journal Title

      Neurological Research Vol.27

      Pages: 94-102

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 脳虚血の画像診断2004

    • Author(s)
      原田雅史
    • Journal Title

      脳神経外科ジャーナル 13巻

      Pages: 755-761

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 雑音から脳活動を拾い上げる2004

    • Author(s)
      原田雅史
    • Journal Title

      電子情報通信学会誌 87巻3号

      Pages: 201-206

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Correlation between flow-sensitive alternating inversion recovery perfusion imaging with different inversion times2004

    • Author(s)
      M.Harada, et al.
    • Journal Title

      Neuroradiology 46巻

      Pages: 649-654

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Correlation between flow-sensitive alternating inversion recovery perfusion imaging with different inversion times2004

    • Author(s)
      Masafumi Harada, et al.
    • Journal Title

      Neuroradiology Vol.46

      Pages: 649-654

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2006-07-11  

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