2004 Fiscal Year Final Research Report Summary
Study about safety and efficacy of percutaneous radiofrequency ablation for lung tumor
| Project/Area Number |
15591294
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Osaka City University |
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Principal Investigator |
MATSUOKA Toshiyuki Osaka City University, Graduate School of Medicine, Lecturer, 大学院・医学研究科, 講師 (40295697)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Kenji Osaka City University, Graduate School of Medicine, Associate Professor, 大学院・医学研究科, 助教授 (00145781)
INOUE Yuichi Osaka City University, Graduate School of Medicine, Professor, 大学院・医学研究科, 教授 (00101288)
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| Project Period (FY) |
2003 – 2004
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| Keywords | radiofrequency ablation / lung ncoplasm / CT-guided puncture |
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| Research Abstract |
As fundamental experiment, we performed RFA in normal lungs of a pig and observed histopathological findings in comparison with a CT image. As a result, three layer configurations which consisted of central coagulative necrosis, the surrounding exudates and the most outer circumferential blood stasis were observed. It was thought that the circular high density area observed in CT corresponded in the most outer circumferential blood stasis with inflammatory cell invasion and fibrosis. The cellular group that did not reach necrosis lay scattered in the most outer circumferential layer. That means that it was important to get a good therapeutic effect at a clinical treatment that target lesion should be included inside the circular high density area in CT.
22 nodules (ten postoperative recurrences of primary lung cancer and 12 metastases from the other organ) of 17 case could be added during study period. So, out of 86 nodules we performed RFA on since June 2000 till now, we evaluated clin
… More
ical results in 40 nodules less than 3cm which were observed more than 6 months after RFA.
Local control rate was 81.8% in 33 nodules which reached roll off although it was 28.6% in seven nodules which did not do roll off. A significant difference was recognized between both. As for major complications, it revealed pain and/or heat sensation in 57.2%, postoperative fever in 51.4% and pneumothorax in 30.4%. Serious complications were not experienced except two cases who were inserted a chest tube because of moderate pneumothorax.
We reported these results at the 33rd meeting of society of Japanese angiography and IVR (Tokyo), the 45th meeting of Japan lung cancer society (Yokohama), RSNA2004 (Chicago), ECR2005 (Vienna). In addition, occurrence of intravascular microembolisms caused by heat during RFA procedure was evaluated. Mocroemboli were observed in three of 20 procedures in 17 cases by monitoring a carotid artery using ultrasound image. However, diffusion MRI showed no cerebral infarction in 20 cases containing containing 17 US cases. The result was reported in American Journal of Roentogenology. Less
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