2004 Fiscal Year Final Research Report Summary

Liver atrophy and Lipid metabolism after mesocaval and portocaval shunt in the rats

Research Project

Project/Area Number	15591333
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	General surgery
Research Institution	TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
Principal Investigator	ABE Hideki Toyama Medical and Pharmaceutical University, Lecturer, 附属病院, 講師 (90345562)
Co-Investigator(Kenkyū-buntansha)	NAGATA Takuya Toyama Medical and Pharmaceutical University, Assistant, 医学部, 助手 (40303242) NOZAWA Satoshi Toyama Medical and Pharmaceutical University, Assistant, 附属病院, 助手 (30345582) TSUKADA Kazuhiro Toyama Medical and Pharmaceutical University, Professor, 医学部, 教授 (90171967) SHIMANO Hitoshi Tsukuba University, Assistant Professor, 医学部, 助教授 (20251241) YAMADA Nobuhiro Tsukuba University, Professor, 医学部, 教授 (40200729)
Project Period (FY)	2003 – 2004
Keywords	Mesocaval shunt / Portocaval shunt / Triglyceride / Free fatty acid
Research Abstract	Surgical splanchnic circulatory diversion into the systemic circulation, such as posrtocaval shunting or mesocaval shunting, has still been reported to treat bleeding esophageal varices caused by portal hypertension in the present era of liver transplantation. Even in liver transplanted recipients, surgical portosystemic shunting has been indicated to alleviate successfully portal hypertension, and in order to avoid graft congestion and failure by overperfusion in adult recipients using small-for-size partial liver graft. When a surgical portosystemic shunting is necessary in a patient with intrinsic liver disease, the possibility of future liver transplantation has to be considered. In liver transplanted recipients, however, surgical shunt cannot be closed whenever hepatic encephalopathy does not develop. Body weight of mesocaval shunt group did not significantly less increase in comparison with control group. While, liver weight of mesocaval shunt significantly less increased in comparison with control group. Triglyceride secretion rate of mesocaval shunt significalntly less increased in comparison with control group. Triglyceride secretion rate of mesocaval shunt significantly correlated with liver weight.