2004 Fiscal Year Final Research Report Summary
Establishment of dendritic cell vaccines targeting a tumor antigen, MUC1 and application for its clinical therapeutics for cancer.
| Project/Area Number |
15591340
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kagawa University (2004)
Shiga University of Medical Science (2003) |
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Principal Investigator |
KONTANI Keiichi Kagawa Univiesity, Faculty of Medicine, Second Department of Surgery, Associate professor (Lecturer), 医学部附属病院, 講師 (90314153)
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| Project Period (FY) |
2003 – 2004
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| Keywords | dendritic cell / cancer vaccine / tumor antigen / immunotherapy / MUC1 |
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| Research Abstract |
The use of dendritic cells (DCs) for cancer vaccination is effective in suppressing cancer progression. This is because the DCs play a crucial role in priming tumor-specific immunity efficiently as antigen-presenting cells. In this study, we analyzed the ability of DCs to elicit tumor-specific immunity and clinical effects of DC vaccine immunotherapy targeting MUC1 tumor antigens. DCs from 14 patients with advanced or metastatic breast or lung cancer (9 positive for MUC1 and 5 negative for MUC1) were loaded with MUC1 antigens or tumor lysate and used for therapeutic vaccination. After vaccination, all of the MUC1-positive patients acquired antigen-specific immunity whereas only one case with MUC1-negative cancer showed the specific immunity. Clinically, marked effects such as reduction in tumor sizes or tumor marker levels or disappearance of malignant pleural effusion were observed in 7 of the 9 MUC1-positive cases. However, MUC1-negative patients did not respond to DC vaccines, with the exception of one case with MAGE3-positive lung cancer. Survival of MUC1-positive patients was significantly prolonged in comparison with MUC1-negative patients (mean survival : 16.75 versus 3.80 months, p=.0101). These data suggest that MUC1 is sufficiently immunogenic to elicit strong anti-tumor immunity as a tumor antigen and that DC vaccines targeting MUC1 are useful for immunotherapy of cancer.
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[Journal Article] Identification of antigenic epitopes recognized by Mac-2 binding protein-specific cytotoxic T lymphocytes in an HLA-A24 restricted manner.2004
Author(s)
Kontani, K., Teramono, K., Ozaki, Y., Fujita, T., Tezuka, T., Sawai, S., Watanabe, H., Fujino, S., Yokomise, H., Ohkubo, I.
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Journal Title
Int.J.Oncol. 25
Pages: 1537-1542
Description
「研究成果報告書概要(欧文)」より
