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2004 Fiscal Year Final Research Report Summary

Irradiation for Ex vivo graft to prevent the small-bowel rejection

Research Project

Project/Area Number 15591366
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionNihon University

Principal Investigator

SUGITO Kiminobu  Nihon University, Graduate School of medicine, staff, 医学部, 助手 (10328750)

Co-Investigator(Kenkyū-buntansha) FUKUZAWA Masahiro  Osaka University, Graduate School of medicine, Professor, 大学院・医学系研究科, 教授 (60165272)
Project Period (FY) 2003 – 2004
Keywordssmall bowel transplantation
Research Abstract

MAdCAM-1 expression on HEVs in PPs was down-regulated during rejection. In contrast its expression on endothelial cells of vessels in the lumina propria was up-regulated during rejection. On day 5 the number of Fas- and FasL-postive enterocytes were increased significantly in the allografts compared with the nontransplanted controls. Similarly, in the PPs, Fas- and FasL-positive mononuclear cells also increased significantly on day 5 in the allografts. Alteration in MAdCAM-1 expression may be associated with the development of SB graft rejection. Activation of fes/FasL system occurred during SB graft rejection suggest that it may be associated with the development of SB graft rejection.
We also studied about the effect of ex vivo graft irradiation and FTY720. Graft survival was prolonged in FTY720 model and ex vivo graft irradiation +FTY720 model. In FTY720 model and ex vivo graft irradiation +FTY720 model, the number of the expression of MAdCAM-1 expression on HEVs in PPs and, Fas/FasL-positive mononuclear cells in the PPs were decreased.
These findings suggest that ex vivo graft irradiation +FTY720 is important for the control of SB graft rejection.

  • Research Products

    (11 results)

All 2004 2003 2002

All Journal Article (11 results)

  • [Journal Article] Apotosis of Cript Cells and Lymphocytes in Gut-Associated Lymphoid Tissues During Small Intestinal Graft Rejection in Rats2004

    • Author(s)
      Y.J.Park
    • Journal Title

      Transplantation Proceedings 36

      Pages: 353-355

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Semiquantative Analysis of Expression of Mucosal Addressin Cell Adhesion Molecule-1 During Small Bowel Graft Rejection in Rats2004

    • Author(s)
      S.Fujisaki
    • Journal Title

      Transplantation Proceedings 36

      Pages: 348-349

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Expression of mucosal addression cell adhesion molecule-1(MAdCAM-1) during small-bowel graft rejection in rats2003

    • Author(s)
      藤崎 滋
    • Journal Title

      Scand J Gastroenterol 4

      Pages: 437-442

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 末梢性リンパ性器官を持たないマウスに対する新規免疫抑制剤FTY720の効果2003

    • Author(s)
      杉藤 公信
    • Journal Title

      日本移植学会誌 38

      Pages: 285-292

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] マウスにおける組織,異所性心臓移植に対する新規免疫抑制剤FTY720の効果の検討2003

    • Author(s)
      杉藤 公信
    • Journal Title

      日本移植学会誌 38

      Pages: 279-284

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] ラット同所性全小腸移植拒絶反応における陰窩細胞とパイエル板構成細胞のアポトーシスの関与に関する検討2003

    • Author(s)
      朴 英智
    • Journal Title

      日本移植学会誌 38

      Pages: 340-348

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Expression of mucosal addression cell adhesion molecule-1(MAdCAM-1) during small-bowel graft rejection in rats2003

    • Author(s)
      S.Fujisaki
    • Journal Title

      Scand J Gastroenterol 4

      Pages: 437-442

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Effect of a novel immunosuppressant FTY720 in mice without secondary lymphoid organs2003

    • Author(s)
      K.Sugito
    • Journal Title

      Japanese Journal of Transplantation 38

      Pages: 285-292

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The Effect of Organ, Tissue and Cardiac Allograft of a Novel Immunosuppressant FTY720 in Mice2003

    • Author(s)
      K.Sugito
    • Journal Title

      Japanese Journal of Transplantation 38

      Pages: 279-284

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 小腸移植拒絶反応における腸管粘膜防御機構の破碇-特にpeyer板の変化に関して2002

    • Author(s)
      藤崎 滋
    • Journal Title

      The Japanese Society of Digestion and Absorption 25

      Pages: 55-58

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Breakdown of mucosal immune system in small bowel graft rejection2002

    • Author(s)
      S.Fujisaki
    • Journal Title

      The Japanese Society of Digestion and Absorption 25

      Pages: 55-59

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2006-07-11  

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